List all articles in the database by descending article_id

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    "count": 15514,
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        {
            "article_id": 1121928,
            "title": "TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n<jats:title>Background</jats:title>\n<jats:p>Neuroinflammation is one of the most important processes in secondary injury after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) has been proven to exert neuroprotective effects in neurodegenerative diseases and stroke by modulating neuroinflammation, and promoting phagocytosis and cell survival. However, the role of TREM2 in TBI has not yet been elucidated. In this study, we are the first to use COG1410, an agonist of TREM2, to assess the effects of TREM2 activation in a murine TBI model.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Methods</jats:title>\n<jats:p>Adult male wild-type (WT) C57BL/6 mice and adult male TREM2 KO mice were subjected to different treatments. TBI was established by the controlled cortical impact (CCI) method. COG1410 was delivered 1 h after CCI via tail vein injection. Western blot analysis, immunofluorescence, laser speckle contrast imaging (LSCI), neurological behaviour tests, brain electrophysiological monitoring, Evans blue assays, magnetic resonance imaging (MRI), and brain water content measurement were performed in this study.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Results</jats:title>\n<jats:p>The expression of endogenous TREM2 peaked at 3 d after CCI, and it was mainly expressed on microglia and neurons. We found that COG1410 improved neurological functions within 3 d, as well as neurological functions and brain electrophysiological activity at 2 weeks after CCI. COG1410 exerted neuroprotective effects by inhibiting neutrophil infiltration and microglial activation, and suppressing neuroinflammation after CCI. In addition, COG1410 treatment alleviated blood brain barrier (BBB) disruption and brain oedema; furthermore, COG1410 promoted cerebral blood flow (CBF) recovery at traumatic injury sites after CCI. In addition, COG1410 suppressed neural apoptosis at 3 d after CCI. TREM2 activation upregulated p-Akt, p-CREB, BDNF, and Bcl-2 and suppressed TNF-α, IL-1β, Bax, and cleaved caspase-3 at 3 d after CCI. Moreover, TREM2 knockout abolished the effects of COG1410 on vascular phenotypes and microglial states. Finally, the neuroprotective effects of COG1410 were suppressed by TREM2 depletion.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Conclusions</jats:title>\n<jats:p>Altogether, we are the first to demonstrate that TREM2 activation by COG1410 alleviated neural damage through activation of Akt/CREB/BDNF signalling axis in microglia after CCI. Finally, COG1410 treatment improved neurological behaviour and brain electrophysiological activity after CCI.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Graphical Abstract</jats:title>\n</jats:sec>",
            "link": "https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-022-02651-3",
            "published_date": "2022-12-03T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Neuroinflammation",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/7649/",
                    "family_name": "Wang",
                    "given_name": "Lin",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/11847/",
                    "family_name": "Zhang",
                    "given_name": "Yuan",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/39067/",
                    "family_name": "Li",
                    "given_name": "Lin",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/67728/",
                    "family_name": "Yan",
                    "given_name": "Jin",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/67729/",
                    "family_name": "Wang",
                    "given_name": "Yingwen",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/67732/",
                    "family_name": "Sun",
                    "given_name": "Xiaochuan",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81105/",
                    "family_name": "Li",
                    "given_name": "Zhao",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81106/",
                    "family_name": "Tang",
                    "given_name": "Shuang",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81107/",
                    "family_name": "Gu",
                    "given_name": "Nina",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-04T01:23:10.096715Z",
            "noun_phrases": [
                "TREM2 activation",
                "neural damage",
                "Akt/CREB/BDNF",
                "traumatic brain injury",
                "mice"
            ],
            "doi": "10.1186/s12974-022-02651-3",
            "access": "open",
            "takeaways": " Triggering receptor expressed on myeloid cells 2 (TREM2) has been proven to exert neuroprotective effects in neurodegenerative diseases and stroke by modulating neuroinflammation, and promoting phagocytosis and cell survival . In this study, we are the first to use COG1410, an agonist of TREM2, to assess the effects of the receptor's activation in a murine TBI model ."
        },
        {
            "article_id": 1121330,
            "title": "Determining the safety and effectiveness of Tai Chi: a critical overview of 210 systematic reviews of controlled clinical trials",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n<jats:title>Background</jats:title>\n<jats:p>This overview summarizes the best available systematic review (SR) evidence on the health effects of Tai Chi.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Methods</jats:title>\n<jats:p>Nine databases (PubMed, Cochrane Library, EMBASE, Medline, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Sino-Med, and Wanfang Database) were searched for SRs of controlled clinical trials of Tai Chi interventions published between Jan 2010 and Dec 2020 in any language. Effect estimates were extracted from the most recent, comprehensive, highest-quality SR for each population, condition, and outcome. SR quality was appraised with AMSTAR 2 and overall certainty of effect estimates with the GRADE method.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Results</jats:title>\n<jats:p>Of the 210 included SRs, 193 only included randomized controlled trials, one only included non-randomized studies of interventions, and 16 included both. Common conditions were neurological (18.6%), falls/balance (14.7%), cardiovascular (14.7%), musculoskeletal (11.0%), cancer (7.1%), and diabetes mellitus (6.7%). Except for stroke, no evidence for disease prevention was found; however, multiple proxy-outcomes/risks factors were evaluated. One hundred and fourteen effect estimates were extracted from 37 SRs (2 high, 6 moderate, 18 low, and 11 critically low quality), representing 59,306 adults. Compared to active and/or inactive controls, 66 of the 114 effect estimates reported clinically important benefits from Tai Chi, 53 reported an equivalent or marginal benefit, and 6 an equivalent risk of adverse events. Eight of the 114 effect estimates (7.0%) were rated as high, 43 (37.7%) moderate, 36 (31.6%) low, and 27 (23.7%) very low certainty evidence due to concerns with risk of bias (92/114, 80.7%), imprecision (43/114, 37.7%), inconsistency (37/114, 32.5%), and publication bias (3/114, 2.6%). SR quality was often limited by the search strategies, language bias, inadequate consideration of clinical, methodological, and statistical heterogeneity, poor reporting standards, and/or no registered SR protocol.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Conclusions</jats:title>\n<jats:p>The findings suggest Tai Chi has multidimensional effects, including physical, psychological and quality of life benefits for a wide range of conditions, as well as multimorbidity. Clinically important benefits were most consistently reported for Parkinson’s disease, falls risk, knee osteoarthritis, low back pain, cerebrovascular, and cardiovascular diseases including hypertension. For most conditions, higher-quality SRs with rigorous primary studies are required.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Systematic review registration</jats:title>\n<jats:p>PROSPERO CRD42021225708.</jats:p>\n</jats:sec>",
            "link": "https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-022-02100-5",
            "published_date": "2022-12-03T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Systematic Reviews",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/31264/",
                    "family_name": "Wayne",
                    "given_name": "Peter M.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81099/",
                    "family_name": "Yang",
                    "given_name": "Guo-Yan",
                    "ORCID": "http://orcid.org/0000-0002-8012-2379"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81100/",
                    "family_name": "Hunter",
                    "given_name": "Jennifer",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81101/",
                    "family_name": "Bu",
                    "given_name": "Fan-Long",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81102/",
                    "family_name": "Hao",
                    "given_name": "Wen-Li",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81103/",
                    "family_name": "Zhang",
                    "given_name": "Han",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81104/",
                    "family_name": "Liu",
                    "given_name": "Jian-Ping",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T15:22:26.235656Z",
            "noun_phrases": [
                "the safety",
                "effectiveness",
                "Tai Chi",
                "a critical overview",
                "210 systematic reviews",
                "controlled clinical trials"
            ],
            "doi": "10.1186/s13643-022-02100-5",
            "access": "open",
            "takeaways": " The findings suggest Tai Chi has multidimensional effects, including physical, psychological and quality of life benefits for a wide range of conditions . Except for stroke, no evidence for disease prevention was found ."
        },
        {
            "article_id": 1121223,
            "title": "Prevalence, risk factors and quality of life impact of work-related musculoskeletal disorders among school teachers in Cairo, Egypt",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n<jats:title>Background</jats:title>\n<jats:p>School teachers constitute an occupational group which reported a high prevalence of work-related musculoskeletal disorders (WRMSDs). Different individual, occupational and psychosocial factors have been identified to influence the complex process of WRMSDs. WRMSDs represent an important and costly occupational health problem being responsible for a poor quality of life (QOL) of teachers<jats:bold>.</jats:bold> This study aimed to determine the prevalence, the risk factors, and the impact of WRMSDs on the QOL of teachers.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Methods</jats:title>\n<jats:p>310 full-time teachers from 15 public schools were surveyed using an interview questionnaire about their sociodemographic and occupational characteristics, the Nordic Musculoskeletal Questionnaire and the SF-36 Health Survey (SF-36).</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Results</jats:title>\n<jats:p>Self-reported prevalence of WRMSDs at any body part over the past 12 months among teachers was 66.77%. Neck pain (56.1%) was the most prevalent WRMSD followed by shoulders (53.2%), low back (53.2%) and knees (50.6%) pain. Female gender, body mass index, the number of students per classroom, the number of classes per week, different adapted awkward postures and the lack of enough supervisor’s psychological support at work were among the risk factors positively associated with WRMSDs. WRMSDs had a negative impact on the physical and mental QOL of teachers with WRMSDs as reflected by their lower scores on all scales of the SF-36 compared to their counterparts without WRMSDs (<jats:italic>p</jats:italic> ˂ 0.05).</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Conclusion</jats:title>\n<jats:p>WRMSDs were a highly prevalent problem among teachers in Cairo, Egypt and negatively influencing their physical and mental QOL. Different individual, occupational and psychosocial factors had been shown to be significant predictors for the occurrence of WRMSDs reflecting their complex nature and multifactorial etiology.</jats:p>\n</jats:sec>",
            "link": "https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-022-14712-6",
            "published_date": "2022-12-03T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "BMC Public Health",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/81095/",
                    "family_name": "Fahmy",
                    "given_name": "Viviane Farid",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81096/",
                    "family_name": "Momen",
                    "given_name": "Mohamed Abdel Maguid Tolba",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81097/",
                    "family_name": "Mostafa",
                    "given_name": "Nayera Samy",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81098/",
                    "family_name": "Elawady",
                    "given_name": "Mohamed Yehia",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T13:22:42.824929Z",
            "noun_phrases": [
                "Prevalence",
                "risk factors",
                "quality",
                "life impact",
                "work-related musculoskeletal disorders",
                "school teachers",
                "Cairo",
                "Egypt"
            ],
            "doi": "10.1186/s12889-022-14712-6",
            "access": "open",
            "takeaways": " Neck pain (56.1%) was the most prevalent WRMSD followed by shoulders, shoulders, low back and knees pain . Female gender, body mass index, number of students per classroom, the number of classes per classroom and different adapted awkward postures were among the risk factors positively associated with WRMSDs ."
        },
        {
            "article_id": 1121051,
            "title": "Prognostic relevance of quantitative and longitudinal MOG antibody testing in patients with MOGAD: a multicentre retrospective study",
            "summary": "<div><p>J Neurol Neurosurg Psychiatry. 2022 Dec 2:jnnp-2022-330237. doi: 10.1136/jnnp-2022-330237. Online ahead of print.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36460438/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20221203055013&amp;v=2.17.9\">36460438</a> | DOI:<a href=\"https://doi.org/10.1136/jnnp-2022-330237\">10.1136/jnnp-2022-330237</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36460438/?fc=20210216052009&ff=20221203055013&v=2.17.9",
            "published_date": "2022-12-02T11:00:00Z",
            "source": "PubMed",
            "publisher": "Journal of Neurology, Neurosurgery &amp; Psychiatry",
            "container_title": "Journal of Neurology, Neurosurgery &amp; Psychiatry",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/1242/",
                    "family_name": "Gallo",
                    "given_name": "Antonio",
                    "ORCID": null
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                {
                    "url": "http://api.gregory-ms.com/authors/1312/",
                    "family_name": "Moiola",
                    "given_name": "Lucia",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/1345/",
                    "family_name": "Brambilla",
                    "given_name": "Laura",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/1482/",
                    "family_name": "Rigoni",
                    "given_name": "Eleonora",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/2793/",
                    "family_name": "Mariotto",
                    "given_name": "Sara",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/7431/",
                    "family_name": "Ferrari",
                    "given_name": "Sergio",
                    "ORCID": null
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                    "family_name": "Novi",
                    "given_name": "Giovanni",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/23616/",
                    "family_name": "Jarius",
                    "given_name": "Sven",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/25977/",
                    "family_name": "Colombo",
                    "given_name": "Elena",
                    "ORCID": null
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                    "family_name": "Ballante",
                    "given_name": "Elena",
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                    "family_name": "Franciotta",
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                    "family_name": "Gastaldi",
                    "given_name": "Matteo",
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                    "url": "http://api.gregory-ms.com/authors/26182/",
                    "family_name": "Ruggieri",
                    "given_name": "Martino",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/30344/",
                    "family_name": "Banfi",
                    "given_name": "Paola",
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                    "family_name": "Nosadini",
                    "given_name": "Margherita",
                    "ORCID": "http://orcid.org/0000-0002-6395-7614"
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                    "url": "http://api.gregory-ms.com/authors/38535/",
                    "family_name": "Sartori",
                    "given_name": "Stefano",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/66504/",
                    "family_name": "Masciocchi",
                    "given_name": "Stefano",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/80650/",
                    "family_name": "Della Corte",
                    "given_name": "Marida",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/80668/",
                    "family_name": "Savasta",
                    "given_name": "Salvatore",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/81083/",
                    "family_name": "Foiadelli",
                    "given_name": "Thomas",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/81084/",
                    "family_name": "Greco",
                    "given_name": "Giacomo",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/81085/",
                    "family_name": "Scaranzin",
                    "given_name": "Silvia",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/81086/",
                    "family_name": "Mancinelli",
                    "given_name": "Chiara",
                    "ORCID": "http://orcid.org/0000-0001-5884-9646"
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                {
                    "url": "http://api.gregory-ms.com/authors/81087/",
                    "family_name": "Mancardi",
                    "given_name": "Margherita",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/81088/",
                    "family_name": "Giacomini",
                    "given_name": "Thea",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/81089/",
                    "family_name": "Ferraro",
                    "given_name": "Diana",
                    "ORCID": "http://orcid.org/0000-0003-4818-3806"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81090/",
                    "family_name": "Di Filippo",
                    "given_name": "Massimiliano",
                    "ORCID": "http://orcid.org/0000-0002-2645-7477"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81091/",
                    "family_name": "Benedetti",
                    "given_name": "Luana",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81092/",
                    "family_name": "Versino",
                    "given_name": "Maurizio",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81093/",
                    "family_name": "Iorio",
                    "given_name": "Raffaele",
                    "ORCID": "http://orcid.org/0000-0002-6270-0956"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81094/",
                    "family_name": "Turco",
                    "given_name": "Emanuela",
                    "ORCID": null
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            ],
            "relevant": false,
            "ml_prediction_gnb": true,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T10:50:58.411976Z",
            "noun_phrases": [
                "Prognostic relevance",
                "quantitative and longitudinal MOG antibody testing",
                "patients",
                "MOGAD",
                "a multicentre retrospective study"
            ],
            "doi": "10.1136/jnnp-2022-330237",
            "access": "restricted",
            "takeaways": ""
        },
        {
            "article_id": 1121050,
            "title": "Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder",
            "summary": "<div><p>Neurology. 2022 Dec 2:10.1212/WNL.0000000000201625. doi: 10.1212/WNL.0000000000201625. Online ahead of print.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36460473/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20221203055013&amp;v=2.17.9\">36460473</a> | DOI:<a href=\"https://doi.org/10.1212/WNL.0000000000201625\">10.1212/WNL.0000000000201625</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36460473/?fc=20210216052009&ff=20221203055013&v=2.17.9",
            "published_date": "2022-12-02T11:00:00Z",
            "source": "PubMed",
            "publisher": "Neurology",
            "container_title": "Neurology",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/1094/",
                    "family_name": "Tillema",
                    "given_name": "Jan-Mendelt",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/1201/",
                    "family_name": "Weinstock-Guttman",
                    "given_name": "Bianca",
                    "ORCID": "http://orcid.org/0000-0001-6732-151X"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/3915/",
                    "family_name": "Chitnis",
                    "given_name": "Tanuja",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/4216/",
                    "family_name": "Roalstad",
                    "given_name": "Shelly",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/4217/",
                    "family_name": "Casper",
                    "given_name": "Charles",
                    "ORCID": null
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                    "url": "http://api.gregory-ms.com/authors/4219/",
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                    "url": "http://api.gregory-ms.com/authors/4220/",
                    "family_name": "Benson",
                    "given_name": "Leslie",
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                    "url": "http://api.gregory-ms.com/authors/4221/",
                    "family_name": "Gorman",
                    "given_name": "Mark",
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                    "url": "http://api.gregory-ms.com/authors/4223/",
                    "family_name": "Goyal",
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                    "url": "http://api.gregory-ms.com/authors/4226/",
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                    "url": "http://api.gregory-ms.com/authors/4228/",
                    "family_name": "Schreiner",
                    "given_name": "Teri",
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                    "url": "http://api.gregory-ms.com/authors/13943/",
                    "family_name": "Ness",
                    "given_name": "Jayne",
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                    "url": "http://api.gregory-ms.com/authors/13952/",
                    "family_name": "Rose",
                    "given_name": "John",
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                {
                    "url": "http://api.gregory-ms.com/authors/39271/",
                    "family_name": "Lotze",
                    "given_name": "Timothy E.",
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                    "url": "http://api.gregory-ms.com/authors/49364/",
                    "family_name": "Harris",
                    "given_name": "Yolanda",
                    "ORCID": null
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                {
                    "url": "http://api.gregory-ms.com/authors/58060/",
                    "family_name": "Waltz",
                    "given_name": "Michael",
                    "ORCID": null
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                {
                    "url": "http://api.gregory-ms.com/authors/81077/",
                    "family_name": "Umeton",
                    "given_name": "Raffaella Pizzolato",
                    "ORCID": "http://orcid.org/0000-0003-2975-1214"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81078/",
                    "family_name": "Aaen",
                    "given_name": "Gregory S",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81079/",
                    "family_name": "Graves",
                    "given_name": "Jennifer S.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81080/",
                    "family_name": "Shukla",
                    "given_name": "Nikita M.",
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                    "url": "http://api.gregory-ms.com/authors/81081/",
                    "family_name": "Rensel",
                    "given_name": "Mary",
                    "ORCID": "http://orcid.org/0000-0001-9613-8394"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81082/",
                    "family_name": "Waubant",
                    "given_name": "Emmanuelle",
                    "ORCID": "http://orcid.org/0000-0001-5188-0157"
                }
            ],
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            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T10:50:46.421328Z",
            "noun_phrases": [
                "Therapeutic Response",
                "Pediatric Neuromyelitis Optica Spectrum Disorder"
            ],
            "doi": "10.1212/WNL.0000000000201625",
            "access": "restricted",
            "takeaways": ""
        },
        {
            "article_id": 1121049,
            "title": "Deciphering clinical abbreviations with a privacy protecting machine learning system",
            "summary": "<div><p>Nat Commun. 2022 Dec 2;13(1):7456. doi: 10.1038/s41467-022-35007-9.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36460656/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20221203055013&amp;v=2.17.9\">36460656</a> | DOI:<a href=\"https://doi.org/10.1038/s41467-022-35007-9\">10.1038/s41467-022-35007-9</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36460656/?fc=20210216052009&ff=20221203055013&v=2.17.9",
            "published_date": "2022-12-02T11:00:00Z",
            "source": "PubMed",
            "publisher": "Nature Communications",
            "container_title": "Nature Communications",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/7864/",
                    "family_name": "Zhang",
                    "given_name": "Yi",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81069/",
                    "family_name": "Rajkomar",
                    "given_name": "Alvin",
                    "ORCID": "http://orcid.org/0000-0001-5750-5016"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81070/",
                    "family_name": "Loreaux",
                    "given_name": "Eric",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81071/",
                    "family_name": "Liu",
                    "given_name": "Yuchen",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81072/",
                    "family_name": "Kemp",
                    "given_name": "Jonas",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81073/",
                    "family_name": "Li",
                    "given_name": "Benny",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81074/",
                    "family_name": "Chen",
                    "given_name": "Ming-Jun",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81075/",
                    "family_name": "Mohiuddin",
                    "given_name": "Afroz",
                    "ORCID": "http://orcid.org/0000-0002-6310-7660"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81076/",
                    "family_name": "Gottweis",
                    "given_name": "Juraj",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T10:50:33.506514Z",
            "noun_phrases": [
                "clinical abbreviations",
                "a privacy",
                "machine learning system"
            ],
            "doi": "10.1038/s41467-022-35007-9",
            "access": "open",
            "takeaways": ""
        },
        {
            "article_id": 1121048,
            "title": "Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance",
            "summary": "<div><p>Nat Commun. 2022 Dec 2;13(1):7449. doi: 10.1038/s41467-022-35263-9.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36460677/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20221203055013&amp;v=2.17.9\">36460677</a> | DOI:<a href=\"https://doi.org/10.1038/s41467-022-35263-9\">10.1038/s41467-022-35263-9</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36460677/?fc=20210216052009&ff=20221203055013&v=2.17.9",
            "published_date": "2022-12-02T11:00:00Z",
            "source": "PubMed",
            "publisher": "Nature Communications",
            "container_title": "Nature Communications",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/47930/",
                    "family_name": "Choi",
                    "given_name": "Seung Woo",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/47932/",
                    "family_name": "Kim",
                    "given_name": "Jaeyun",
                    "ORCID": "http://orcid.org/0000-0002-4687-6732"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81063/",
                    "family_name": "Nguyen",
                    "given_name": "Thanh Loc",
                    "ORCID": "http://orcid.org/0000-0002-8607-569X"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81064/",
                    "family_name": "Choi",
                    "given_name": "Youngjin",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81065/",
                    "family_name": "Im",
                    "given_name": "Jihye",
                    "ORCID": "http://orcid.org/0000-0002-0847-4388"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81066/",
                    "family_name": "Shin",
                    "given_name": "Hyunsu",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81067/",
                    "family_name": "Phan",
                    "given_name": "Ngoc Man",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81068/",
                    "family_name": "Kim",
                    "given_name": "Min Kyung",
                    "ORCID": null
                }
            ],
            "relevant": true,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T10:50:23.556365Z",
            "noun_phrases": [
                "Immunosuppressive biomaterial-based therapeutic vaccine",
                "multiple sclerosis",
                "re",
                "establishing immune tolerance"
            ],
            "doi": "10.1038/s41467-022-35263-9",
            "access": "open",
            "takeaways": ""
        },
        {
            "article_id": 1121047,
            "title": "Economic burden of multiple sclerosis in Slovakia - from 2015 to 2020",
            "summary": "<div><p>BMC Health Serv Res. 2022 Dec 2;22(1):1467. doi: 10.1186/s12913-022-08883-6.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36461018/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20221203055013&amp;v=2.17.9\">36461018</a> | DOI:<a href=\"https://doi.org/10.1186/s12913-022-08883-6\">10.1186/s12913-022-08883-6</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36461018/?fc=20210216052009&ff=20221203055013&v=2.17.9",
            "published_date": "2022-12-02T11:00:00Z",
            "source": "PubMed",
            "publisher": "BMC Health Services Research",
            "container_title": "BMC Health Services Research",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/80981/",
                    "family_name": "Babela",
                    "given_name": "Robert",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/80982/",
                    "family_name": "Dugas",
                    "given_name": "Judit",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-03T10:50:16.079221Z",
            "noun_phrases": [
                "Economic burden",
                "multiple sclerosis",
                "Slovakia"
            ],
            "doi": "10.1186/s12913-022-08883-6",
            "access": "open",
            "takeaways": ""
        },
        {
            "article_id": 1120308,
            "title": "At-home blood self-sampling in rheumatology: a qualitative study with patients and health care professionals",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n<jats:title>Background</jats:title>\n<jats:p>The goal of the study was to investigate patients’ with systemic rheumatic diseases and healthcare professionals’ experiences and preferences regarding self-sampling of capillary blood in rheumatology care.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Methods</jats:title>\n<jats:p>Patients performed a supervised and consecutive unsupervised capillary blood self-collection using an upper arm based device. Subsequently, patients (<jats:italic>n</jats:italic> = 15) and their attending health care professionals (<jats:italic>n</jats:italic> = 5) participated in an explorative, qualitative study using problem-centered, telephone interviews. Interview data were analyzed using structured qualitative content analysis.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Results</jats:title>\n<jats:p>Interviewed patients reported easy application and high usability. Patients and health care professionals alike reported time and cost savings, increased independence and flexibility, improved monitoring and reduction of risk of infection during Covid-19 as benefits. Reported drawbacks include limited blood volume, limited usability in case of functional restrictions, and environmental concerns. Older, immobile patients with long journeys to traditional blood collection sites and young patients with little time to spare for traditional blood collection appointments could be user groups, likely to benefit from self-sampling services.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Conclusions</jats:title>\n<jats:p>At-home blood self-sampling could effectively complement current rheumatology telehealth care. Appropriateness and value of this service needs to be carefully discussed with patients on an individual basis.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Trial Registration</jats:title>\n<jats:p>WHO International Clinical Trials Registry: DRKS00024925. Registered on 15/04/2021.</jats:p>\n</jats:sec>",
            "link": "https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-022-08787-5",
            "published_date": "2022-12-02T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "BMC Health Services Research",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/34873/",
                    "family_name": "Knitza",
                    "given_name": "Johannes",
                    "ORCID": "http://orcid.org/0000-0001-9695-0657"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/34892/",
                    "family_name": "Schett",
                    "given_name": "Georg",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81032/",
                    "family_name": "Muehlensiepen",
                    "given_name": "Felix",
                    "ORCID": "http://orcid.org/0000-0001-8571-7286"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81033/",
                    "family_name": "May",
                    "given_name": "Susann",
                    "ORCID": "http://orcid.org/0000-0003-3847-4861"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81034/",
                    "family_name": "Zarbl",
                    "given_name": "Joshua",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81035/",
                    "family_name": "Vogt",
                    "given_name": "Ekaterina",
                    "ORCID": "http://orcid.org/0000-0002-6942-1714"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81036/",
                    "family_name": "Boy",
                    "given_name": "Katharina",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81037/",
                    "family_name": "Heinze",
                    "given_name": "Martin",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81038/",
                    "family_name": "Boeltz",
                    "given_name": "Sebastian",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81039/",
                    "family_name": "Labinsky",
                    "given_name": "Hannah",
                    "ORCID": "http://orcid.org/0000-0001-5762-9182"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81040/",
                    "family_name": "Bendzuck",
                    "given_name": "Gerlinde",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81041/",
                    "family_name": "Korinth",
                    "given_name": "Marianne",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81042/",
                    "family_name": "Elling-Audersch",
                    "given_name": "Corinna",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81043/",
                    "family_name": "Vuillerme",
                    "given_name": "Nicolas",
                    "ORCID": "http://orcid.org/0000-0003-3773-393X"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81044/",
                    "family_name": "Krönke",
                    "given_name": "Gerhard",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-02T23:22:22.935854Z",
            "noun_phrases": [
                "home",
                "rheumatology",
                "a qualitative study",
                "patients",
                "health care professionals"
            ],
            "doi": "10.1186/s12913-022-08787-5",
            "access": "open",
            "takeaways": " The goal of the study was to investigate patients’ with systemic rheumatic diseases and healthcare professionals’ experiences and preferences regarding self-sampling of capillary blood in rheumatology care . Patients and health care professionals alike reported time and cost savings, increased independence and flexibility ."
        },
        {
            "article_id": 1120202,
            "title": "Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cells",
            "summary": "<jats:title>Abstract</jats:title><jats:p>The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response. ISR activation was reported in neurological disorders and solid tumors; however, the function of ISR and its role as a possible therapeutic target in hematological malignancies still remain largely unexplored. Previously, we showed that the ISR is activated in chronic myeloid leukemia (CML) cells and correlates with blastic transformation and tyrosine kinase inhibitor (TKI) resistance. Moreover, the ISR was additionally activated in response to imatinib as a type of protective internal signaling. Here, we show that ISR inhibition combined with imatinib treatment sensitized and more effectively eradicated leukemic cells both in vitro and in vivo compared to treatment with single agents. The combined treatment specifically inhibited the STAT5 and RAS/RAF/MEK/ERK pathways, which are recognized as drivers of resistance. Mechanistically, this drug combination attenuated both interacting signaling networks, leading to BCR-ABL1- and ISR-dependent STAT5 activation. Consequently, leukemia engraftment in patient-derived xenograft mice bearing CD34+ TKI-resistant CML blasts carrying <jats:italic>PTPN11</jats:italic> mutation responsible for hyperactivation of the RAS/RAF/MAPK and JAK/STAT5 pathways was decreased upon double treatment. This correlated with the downregulation of genes related to the RAS/RAF/MAPK, JAK/STAT5 and stress response pathways and was associated with lower expression of STAT5-target genes regulating proliferation, viability and the stress response. Collectively, these findings highlight the effect of imatinib plus ISRIB in the eradication of leukemic cells resistant to TKIs and suggest potential clinical benefits for leukemia patients with TKI resistance related to RAS/RAF/MAPK or STAT5 signaling. We propose that personalized treatment based on the genetic selection of patients carrying mutations that cause overactivation of the targeted pathways and therefore make their sensitivity to such treatment probable should be considered as a possible future direction in leukemia treatment.</jats:p>",
            "link": "https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10289-w",
            "published_date": "2022-12-02T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "BMC Cancer",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/81017/",
                    "family_name": "Dudka",
                    "given_name": "Wioleta",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81018/",
                    "family_name": "Hoser",
                    "given_name": "Grazyna",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81019/",
                    "family_name": "Mondal",
                    "given_name": "Shamba S.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81020/",
                    "family_name": "Turos-Korgul",
                    "given_name": "Laura",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81021/",
                    "family_name": "Swatler",
                    "given_name": "Julian",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81022/",
                    "family_name": "Kusio-Kobialka",
                    "given_name": "Monika",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81023/",
                    "family_name": "Wołczyk",
                    "given_name": "Magdalena",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81024/",
                    "family_name": "Klejman",
                    "given_name": "Agata",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81025/",
                    "family_name": "Brewinska-Olchowik",
                    "given_name": "Marta",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81026/",
                    "family_name": "Kominek",
                    "given_name": "Agata",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81027/",
                    "family_name": "Wiech",
                    "given_name": "Milena",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81028/",
                    "family_name": "Machnicki",
                    "given_name": "Marcin M.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81029/",
                    "family_name": "Seferynska",
                    "given_name": "Ilona",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81030/",
                    "family_name": "Stoklosa",
                    "given_name": "Tomasz",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/81031/",
                    "family_name": "Piwocka",
                    "given_name": "Katarzyna",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2022-12-02T21:35:18.551523Z",
            "noun_phrases": [
                "integrated stress response",
                "ISRIB",
                "imatinib treatment attenuates RAS/RAF/MAPK",
                "STAT5",
                "chronic myeloid leukemia cells"
            ],
            "doi": "10.1186/s12885-022-10289-w",
            "access": "open",
            "takeaways": " The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response . ISR activation was reported in neurological disorders and solid tumors, but the function of ISR and its role as a possible therapeutic target in hematological malignancies still remain largely unexplored ."
        }
    ]
}