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{ "count": 31312, "next": "http://api.gregory-ms.com/articles/?page=2", "previous": null, "results": [ { "article_id": 291203, "title": "Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression", "summary": "Multiple sclerosis (MS) is a severe autoimmune disorder that wreaks havoc on the central nervous system, leading to a spectrum of motor and cognitive impairments. There is no cure, and current treatment strategies rely on broad immunosuppression, leaving patients vulnerable to infections. To address this problem, our approach aims to induce antigen-specific tolerance, a much-needed shift in MS therapy. We have engineered a tolerogenic therapy consisting of spray-dried particles made of a...", "link": "https://pubmed.ncbi.nlm.nih.gov/39812522/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:31.175296Z", "article_subject_relevances": [], "doi": "10.1021/acsnano.4c14698", "access": "restricted", "takeaways": "MS is an autoimmune disorder that wreaks havoc on the central nervous system. Current treatment strategies rely on broad immunosuppression, leaving patients vulnerable to infections", "team_categories": [], "ml_predictions": [] }, { "article_id": 291202, "title": "Response of miRNA to treatment with <i>Hypericum perforatum</i> L. oil in multiple sclerosis", "summary": "<jats:p>MicroRNA‑regulated gene expression plays an important role in autoimmune diseases, such as multiple sclerosis (MS). This study investigated the expression patterns of microRNAs (miRNAs) in MS in brain tissues using an animal experimental autoimmune encephalomyelitis (EAE) model treated with Hypericum perforatum (HP) oil. C57BL/6 J mice were divided into two groups: MS and control. The MS group was subdivided into sham (MS) and MS+HP. After the EAE induction treatment protocol, the patterns of miRNA expression profiles were determined in brain samples of the groups. The array data identified eleven miRNAs and candidate miRNA validation was performed by RT‑qPCR. A literature review of the validated miRNAs found that six of the eleven miRNAs (miR‑200a‑3p, miR‑200b‑3p, miR‑200c‑3p, miR‑182‑5p, miR‑183‑5p, and miR‑1298‑5p) were directly associated with MS. These miRNAs have been suggested as biomarkers of MS because they are highly correlated with the pathology of the disease. Furthermore, miRNA array analysis identified five candidate miRNAs (miR‑299a‑5p, miR‑206‑3p, miR‑325‑5p, miR‑10b‑5p, miR‑429‑3p) that are highly likely to be associated with MS pathogenesis, which could be helpful in the diagnosis and treatment of MS disease. This research offers vital insights that could be utilized in creating biomarkers and advancing treatments for MS.</jats:p>", "link": "https://pubmed.ncbi.nlm.nih.gov/39812531/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": "The Nencki Institute of Experimental Biology, Polish Academy of Sciences", "container_title": "Acta Neurobiologiae Experimentalis", "authors": [ { "author_id": 388006, "given_name": "Huri", "family_name": "Dedeakayogullari", "ORCID": "https://orcid.org/0000-0003-2706-9625", "country": null }, { "author_id": 388007, "given_name": "Zozan", "family_name": "Guleken", "ORCID": null, "country": null }, { "author_id": 388008, "given_name": "Sahabettin", "family_name": "Selek", "ORCID": null, "country": null }, { "author_id": 388009, "given_name": "Nur", "family_name": "Dogan", "ORCID": null, "country": null }, { "author_id": 388010, "given_name": "Busra", "family_name": "Yuce", "ORCID": null, "country": null }, { "author_id": 388011, "given_name": "Emine Seyda", "family_name": "Teloglu", "ORCID": null, "country": null }, { "author_id": 388012, "given_name": "Gulreyhan", "family_name": "Sonuc", "ORCID": null, "country": null }, { "author_id": 388013, "given_name": "Cagla", "family_name": "Yildiz", "ORCID": null, "country": null }, { "author_id": 388014, "given_name": "Esra", "family_name": "Tiftik", "ORCID": null, "country": null }, { "author_id": 388015, "given_name": "Aysu", "family_name": "Kilic", "ORCID": null, "country": null }, { "author_id": 388016, "given_name": "Beren", "family_name": "Yildizbas", "ORCID": null, "country": null }, { "author_id": 388017, "given_name": "Zeynep Ece", "family_name": "Bulut", "ORCID": null, "country": null } ], "discovery_date": "2025-01-16T00:28:29.397264Z", "article_subject_relevances": [], "doi": "10.55782/ane-2024-2571", "access": "open", "takeaways": "MicroRNA‑regulated gene expression plays an important role in autoimmune diseases, such as multiple sclerosis (MS). This study investigated the expression patterns of microRNAs in MS in brain tissues using an animal experimental autoimmune encephalomyelitis (EAE) model treated with Hypericum perforatum oil.", "team_categories": [], "ml_predictions": [] }, { "article_id": 291201, "title": "<i>Bacillus amyloliquefaciens</i> WF2020 isolated from fermented pickles promotes longevity and health in <i>Caenorhabditis elegans via</i> JNK and p38 MAPK pathways", "summary": "<jats:p>F2020 promoted longevity and health in C. elegans <jats:italic>via</jats:italic> JNK and p38 MAPK pathways.</jats:p>", "link": "https://pubmed.ncbi.nlm.nih.gov/39812611/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": "Royal Society of Chemistry (RSC)", "container_title": "Food & Function", "authors": [ { "author_id": 388002, "given_name": "Ximiao", "family_name": "Yang", "ORCID": null, "country": null }, { "author_id": 253535, "given_name": "Jianwen", "family_name": "Chen", "ORCID": null, "country": null }, { "author_id": 388003, "given_name": "Zhenlin", "family_name": "Liao", "ORCID": "https://orcid.org/0000-0003-0255-7358", "country": null }, { "author_id": 388004, "given_name": "Xiang", "family_name": "Fang", "ORCID": "https://orcid.org/0000-0002-7823-6350", "country": null }, { "author_id": 388005, "given_name": "Jie", "family_name": "Wang", "ORCID": "https://orcid.org/0000-0001-5114-2445", "country": null } ], "discovery_date": "2025-01-16T00:28:27.265904Z", "article_subject_relevances": [], "doi": "10.1039/d4fo03792h", "access": "restricted", "takeaways": "", "team_categories": [], "ml_predictions": [] }, { "article_id": 291200, "title": "Unraveling the inflammation-degeneration tangle in early MS: preliminary insights from ferritin, neurogranin, TREM2, and retinal ganglion cell layer", "summary": "CONCLUSION: This pilot study suggests that neurogranin may be a potential biomarker at the time of MS diagnosis, and the interplay between ferritin, neurogranin, and TREM2 highlights the complex relationship between inflammation, oxidative stress, and neuronal damage in MS. The inverse association of ferritin and neurogranin with GCL thickness warrants further investigation into the role of iron metabolism and synaptic damage in the early stages of the disease.", "link": "https://pubmed.ncbi.nlm.nih.gov/39812684/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:26.340743Z", "article_subject_relevances": [], "doi": "10.1007/s00415-024-12797-0", "access": "restricted", "takeaways": "Neurogranin may be a potential biomarker at the time of MS diagnosis. Interplay between ferritin, neurogranin, and TREM", "team_categories": [], "ml_predictions": [] }, { "article_id": 291199, "title": "CoGames: Development of an adaptive smartphone-based and gamified monitoring tool for cognitive function in Multiple Sclerosis", "summary": "CONCLUSION: Our study showed that the CoGames yield reliable measures across different cognitive domains and difficulty levels and were enjoyable to play. The observed practice effects must be considered, but also indicate sensitivity to change. These results support the hypothesis that adaptive gamified digital tests can serve as a reliable and well-accepted monitoring tool of cognition in PwMS.", "link": "https://pubmed.ncbi.nlm.nih.gov/39812703/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:25.471474Z", "article_subject_relevances": [], "doi": "10.1007/s00415-024-12818-y", "access": "restricted", "takeaways": "The CoGames are reliable and enjoyable to play. The results support the hypothesis that adaptive gamified digital tests can serve as", "team_categories": [], "ml_predictions": [] }, { "article_id": 291198, "title": "Soma and neurite density abnormalities of paramagnetic rim lesions and core-sign lesions in multiple sclerosis", "summary": "CONCLUSIONS: In PRLs, the significant and clinically relevant neurite loss and increased soma fraction and size possibly reflect increased astrogliosis and activated microglia. Core-sign lesions exhibit milder axonal loss, microglia density and astrogliosis, supporting their less destructive nature.", "link": "https://pubmed.ncbi.nlm.nih.gov/39812706/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:24.616609Z", "article_subject_relevances": [], "doi": "10.1007/s00415-025-12887-7", "access": "restricted", "takeaways": "", "team_categories": [], "ml_predictions": [] }, { "article_id": 291197, "title": "MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique", "summary": "CONCLUSIONS: This study provides estimates of incidence and prevalence of MOGAD in the USA and Martinique and shows that, although children are predisposed, the disease is spread broadly across the age spectrum and population-based outcomes are favorable.", "link": "https://pubmed.ncbi.nlm.nih.gov/39812824/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:22.880458Z", "article_subject_relevances": [], "doi": "10.1007/s00415-024-12861-9", "access": "restricted", "takeaways": "", "team_categories": [], "ml_predictions": [] }, { "article_id": 291196, "title": "Ocrelizumab dose selection for treatment of pediatric relapsing-remitting multiple sclerosis: results of the OPERETTA I study", "summary": "CONCLUSION: A dosing regimen of 300 mg ocrelizumab for patients < 35 kg, and 600 mg for patients ≥ 35 kg (every 24 weeks), was selected for the phase 3 OPERETTA II trial (NCT05123703).", "link": "https://pubmed.ncbi.nlm.nih.gov/39812825/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:22.041252Z", "article_subject_relevances": [], "doi": "10.1007/s00415-024-12879-z", "access": "restricted", "takeaways": "", "team_categories": [ { "id": 6, "category_name": "Ocrelizumab", "category_description": "", "category_slug": "ocrelizumab", "category_terms": [ "ocrelizumab", "ocrevus" ] } ], "ml_predictions": [] }, { "article_id": 291195, "title": "Marriage is associated with decreased lesion volumes and less brain atrophy in people with multiple sclerosis", "summary": "CONCLUSION: Being married may be associated with improved MS outcomes as evidenced by decreased radiographic MS disease burden.", "link": "https://pubmed.ncbi.nlm.nih.gov/39812835/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:21.136532Z", "article_subject_relevances": [], "doi": "10.1007/s00415-024-12823-1", "access": "restricted", "takeaways": "", "team_categories": [], "ml_predictions": [] }, { "article_id": 291194, "title": "Anatomy-driven segmentation of parafoveal optical coherence tomography (OCT) measures may improve associations with clinical outcomes in multiple sclerosis", "summary": "CONCLUSION: This investigation supports the potential use of parafoveal OCT segmentation as an alternative assessment method in detecting neuroinflammatory and neurodegenerative processes in MS. Averaging of the parafoveal retinal layer thickness into the OCT measures may increase the sensitivity of the standard macular OCT segmentation outcomes. Further studies should aim at exploring the reproducibility of this OCT outcome and its longitudinal responsiveness.", "link": "https://pubmed.ncbi.nlm.nih.gov/39812862/?fc=20240915071900&ff=20250115192810&v=2.18.0.post9+e462414", "published_date": "2025-01-15T11:00:00Z", "sources": [ "PubMed for MS" ], "teams": [ { "id": 1, "name": "Team Gregory", "is_active": true, "created": "2024-05-04T18:35:11.961532Z", "modified": "2024-07-04T10:58:33.274216Z", "slug": "team-gregory", "users": [ 3, 1 ] } ], "subjects": [ { "id": 1, "subject_name": "Multiple Sclerosis", "description": null, "team_id": 1 } ], "publisher": null, "container_title": null, "authors": [], "discovery_date": "2025-01-16T00:28:20.230180Z", "article_subject_relevances": [], "doi": "10.1007/s00415-024-12866-4", "access": "restricted", "takeaways": " the potential use of parafoveal OCT segmentation as an alternative assessment method in detecting neuroinflammatory and neurodegenerative processes", "team_categories": [], "ml_predictions": [] } ] }