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{ "count": 22109, "next": "http://api.gregory-ms.com/articles/?page=2", "previous": null, "results": [ { "article_id": 167400, "title": "Metabolite itaconate in host immunoregulation and defense", "summary": null, "link": "https://cmbl.biomedcentral.com/articles/10.1186/s11658-023-00503-3", "published_date": "2023-12-02T00:00:00Z", "source": "BioMedCentral", "publisher": "Springer Science and Business Media LLC", "container_title": "Cellular & Molecular Biology Letters", "authors": [ { "author_id": 336133, "given_name": "Wenchang", "family_name": "Yang", "ORCID": null, "country": null }, { "author_id": 336134, "given_name": "Yaxin", "family_name": "Wang", "ORCID": null, "country": null }, { "author_id": 336135, "given_name": "Kaixiong", "family_name": "Tao", "ORCID": null, "country": null }, { "author_id": 336136, "given_name": "Ruidong", "family_name": "Li", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": null, "ml_prediction_lr": null, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T22:35:30.175889Z", "noun_phrases": [ "Metabolite", "host immunoregulation", "defense" ], "doi": "10.1186/s11658-023-00503-3", "access": "restricted", "takeaways": null, "categories": [] }, { "article_id": 167104, "title": "Recurrent de novo <em>SPTLC2</em> variant causes childhood-onset amyotrophic lateral sclerosis (ALS) by excess sphingolipid synthesis", "summary": "<div><p>J Neurol Neurosurg Psychiatry. 2023 Nov 24:jnnp-2023-332132. doi: 10.1136/jnnp-2023-332132. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motor neurons with varying ages of onset, progression and pathomechanisms. Monogenic childhood-onset ALS, although rare, forms an important subgroup of ALS. We recently reported specific <i>SPTLC1</i> variants resulting in sphingolipid overproduction as a cause for juvenile ALS. Here, we report six patients from six independent families with a recurrent, de novo, heterozygous variant in <i>SPTLC2</i> c.778G>A [p.Glu260Lys] manifesting with juvenile ALS.</p><p>METHODS: Clinical examination of the patients along with ancillary and genetic testing, followed by biochemical investigation of patients' blood and fibroblasts, was performed.</p><p>RESULTS: All patients presented with early-childhood-onset progressive weakness, with signs and symptoms of upper and lower motor neuron degeneration in multiple myotomes, without sensory neuropathy. These findings were supported on ancillary testing including nerve conduction studies and electromyography, muscle biopsies and muscle ultrasound studies. Biochemical investigations in plasma and fibroblasts showed elevated levels of ceramides and unrestrained de novo sphingolipid synthesis. Our studies indicate that <i>SPTLC2</i> variant [c.778G>A, p.Glu260Lys] acts distinctly from hereditary sensory and autonomic neuropathy (HSAN)-causing <i>SPTLC2</i> variants by causing excess canonical sphingolipid biosynthesis, similar to the recently reported <i>SPTLC1</i> ALS associated pathogenic variants. Our studies also indicate that serine supplementation, which is a therapeutic in <i>SPTLC1</i> and <i>SPTCL2</i>-associated HSAN, is expected to exacerbate the excess sphingolipid synthesis in serine palmitoyltransferase (SPT)-associated ALS.</p><p>CONCLUSIONS: <i>SPTLC2</i> is the second SPT-associated gene that underlies monogenic, juvenile ALS and further establishes alterations of sphingolipid metabolism in motor neuron disease pathogenesis. Our findings also have important therapeutic implications: serine supplementation must be avoided in SPT-associated ALS, as it is expected to drive pathogenesis further.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38041679/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202124035&v=2.17.9.post6+86293ac\">38041679</a> | DOI:<a href=\"https://doi.org/10.1136/jnnp-2023-332132\">10.1136/jnnp-2023-332132</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38041679/?fc=20210216052009&ff=20231202124035&v=2.17.9.post6+86293ac", "published_date": "2023-12-02T11:00:00Z", "source": "PubMed", "publisher": "Journal of Neurology, Neurosurgery & Psychiatry", "container_title": "Journal of Neurology, Neurosurgery & Psychiatry", "authors": [ { "author_id": 336127, "given_name": "Safoora B", "family_name": "Syeda", "ORCID": "http://orcid.org/0009-0009-3250-6755", "country": null }, { "author_id": 336128, "given_name": "Museer A", "family_name": "Lone", "ORCID": null, "country": null }, { "author_id": 336129, "given_name": "Payam", "family_name": "Mohassel", "ORCID": null, "country": null }, { "author_id": 336130, "given_name": "Sandra", "family_name": "Donkervoort", "ORCID": null, "country": null }, { "author_id": 336131, "given_name": "Pinki", "family_name": "Munot", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2023-12-02T17:40:36.709098Z", "noun_phrases": [ "Recurrent de novo", "em", "SPTLC2</em> variant", "childhood-onset amyotrophic lateral sclerosis", "ALS", "excess sphingolipid synthesis" ], "doi": "10.1136/jnnp-2023-332132", "access": "open", "takeaways": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motor neurons. Monogenic childhood-onset ALS is an important subgroup of ALS. Six patients from six independent families have a recurrent, de novo, heterozygous variant in SPTLC2 c.778G>A, p.Glu260Lys with juvenile ALS.", "categories": [] }, { "article_id": 166766, "title": "Effectiveness and safety of everolimus treatment in patients with tuberous sclerosis complex in real-world clinical practice", "summary": null, "link": "https://ojrd.biomedcentral.com/articles/10.1186/s13023-023-02982-1", "published_date": "2023-12-02T00:00:00Z", "source": "BioMedCentral", "publisher": null, "container_title": null, "authors": [ { "author_id": 336143, "given_name": "Ine", "family_name": "Cockerell", "ORCID": "http://orcid.org/0000-0002-6810-3941", "country": null }, { "author_id": 336144, "given_name": "Jakob", "family_name": "Christensen", "ORCID": null, "country": null }, { "author_id": 336145, "given_name": "Christina E.", "family_name": "Hoei-Hansen", "ORCID": null, "country": null }, { "author_id": 336146, "given_name": "Lotte", "family_name": "Holst", "ORCID": null, "country": null }, { "author_id": 336147, "given_name": "Mikkel", "family_name": "Grenaa Frederiksen", "ORCID": null, "country": null }, { "author_id": 336148, "given_name": "Aart Imran", "family_name": "Issa-Epe", "ORCID": null, "country": null }, { "author_id": 336149, "given_name": "Bård", "family_name": "Nedregaard", "ORCID": null, "country": null }, { "author_id": 262858, "given_name": "Ragnar", "family_name": "Solhoff", "ORCID": null, "country": null }, { "author_id": 274980, "given_name": "Ketil", "family_name": "Heimdal", "ORCID": null, "country": null }, { "author_id": 336150, "given_name": "Cecilie", "family_name": "Johannessen Landmark", "ORCID": null, "country": null }, { "author_id": 336151, "given_name": "Caroline", "family_name": "Lund", "ORCID": null, "country": null }, { "author_id": 298876, "given_name": "Terje", "family_name": "Nærland", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": null, "ml_prediction_lr": null, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T12:35:21.315141Z", "noun_phrases": [ "Effectiveness", "safety", "everolimus treatment", "patients", "tuberous sclerosis complex", "real-world clinical practice" ], "doi": "10.1186/s13023-023-02982-1", "access": "restricted", "takeaways": null, "categories": [] }, { "article_id": 166751, "title": "Non-lesional white matter in relapsing-remitting multiple sclerosis assessed by multicomponent T2 relaxation", "summary": "<div><p>Brain Behav. 2023 Dec 2:e3334. doi: 10.1002/brb3.3334. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>INTRODUCTION: The purpose of the study is to investigate, by T2 relaxation, non-lesional white matter (WM) in relapsing-remitting (RR) multiple sclerosis (MS).</p><p>METHODS: Twenty stable RR MS patients underwent 1.5T Magnetic Resonance Imaging (MRI) with 3D Fluid-Attenuated Inversion-Recovery (FLAIR), 3D-T1-weighted, and T2-relaxation multi-echo sequences. The Lesion Segmentation Tool processed FLAIR images to identify focal lesions (FLs), whereas T1 images were segmented to identify WM and FL sub-volumes with T1 hypo-intensity. Non-lesional WM was obtained as the segmented WM, excluding FL volumes. The multi-echo sequence allowed decomposition into myelin water, intra-extracellular water, and free water (Fw), which were evaluated on the segmented non-lesional WM. Correlation analysis was performed between the non-lesional WM relaxation parameters and Expanded Disability Status Scale (EDSS), disease duration, patient age, and T1 hypo-intense FL volumes.</p><p>RESULTS: The T1 hypo-intense FL volumes correlated with EDSS. On the non-lesional WM, the median Fw correlated with EDSS, disease duration, age, and T1 hypo-intense FL volumes. Bivariate EDSS correlation of FL volumes and WM T2-relaxation parameters did not improve significance.</p><p>CONCLUSION: T2 relaxation allowed identifying subtle WM alterations, which significantly correlated with EDSS, disease duration, and age but do not seem to be EDSS-predictors independent from FL sub-volumes in stable RR patients. Particularly, the increase in the Fw component is suggestive of an uninvestigated prodromal phenomenon in brain degeneration.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38041516/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202070304&v=2.17.9.post6+86293ac\">38041516</a> | DOI:<a href=\"https://doi.org/10.1002/brb3.3334\">10.1002/brb3.3334</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38041516/?fc=20210216052009&ff=20231202070304&v=2.17.9.post6+86293ac", "published_date": "2023-12-02T11:00:00Z", "source": "PubMed", "publisher": null, "container_title": null, "authors": [ { "author_id": 336137, "given_name": "Pietro", "family_name": "Bontempi", "ORCID": "http://orcid.org/0000-0002-7720-8243", "country": null }, { "author_id": 336138, "given_name": "Umberto", "family_name": "Rozzanigo", "ORCID": null, "country": null }, { "author_id": 244554, "given_name": "Sabrina", "family_name": "Marangoni", "ORCID": null, "country": null }, { "author_id": 336139, "given_name": "Elena", "family_name": "Fogazzi", "ORCID": null, "country": null }, { "author_id": 336140, "given_name": "Daniele", "family_name": "Ravanelli", "ORCID": null, "country": null }, { "author_id": 336141, "given_name": "Lucia", "family_name": "Cazzoletti", "ORCID": null, "country": null }, { "author_id": 244530, "given_name": "Bruno", "family_name": "Giometto", "ORCID": null, "country": null }, { "author_id": 336142, "given_name": "Paolo", "family_name": "Farace", "ORCID": "http://orcid.org/0000-0002-6051-2345", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2023-12-02T12:03:06.839056Z", "noun_phrases": [ "Non-lesional white matter", "relapsing-remitting multiple sclerosis", "multicomponent T2 relaxation" ], "doi": "10.1002/brb3.3334", "access": "restricted", "takeaways": "20 RR MS patients underwent 1.5T Magnetic Resonance Imaging (MRI) with 3D Fluid-Attenuated Inversion-Recovery (FLAIR), 3D-T1-weighted, and T2-relaxation multi-echo sequences. Non-lesional white matter (WM) in MS patients was segmented into myelin water, intra-extracellular water, and free water (Fw). The median Fw correlated with", "categories": [] }, { "article_id": 166404, "title": "Is multiple sclerosis a glymphaticopathy?", "summary": "<div><p>Mult Scler Relat Disord. 2023 Nov 20;80:105141. doi: 10.1016/j.msard.2023.105141. Online ahead of print.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38039696/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac\">38039696</a> | DOI:<a href=\"https://doi.org/10.1016/j.msard.2023.105141\">10.1016/j.msard.2023.105141</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38039696/?fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac", "published_date": "2023-12-01T11:00:00Z", "source": "PubMed", "publisher": "Multiple Sclerosis and Related Disorders", "container_title": "Multiple Sclerosis and Related Disorders", "authors": [ { "author_id": 336124, "given_name": "Alaa A", "family_name": "Alghanimy", "ORCID": null, "country": null }, { "author_id": 336125, "given_name": "Gavin", "family_name": "Giovannoni", "ORCID": null, "country": null }, { "author_id": 237044, "given_name": "Jeanette", "family_name": "Lechner-Scott", "ORCID": null, "country": null }, { "author_id": 334262, "given_name": "Michael", "family_name": "Levy", "ORCID": null, "country": null }, { "author_id": 336126, "given_name": "E. Ann", "family_name": "Yeh", "ORCID": null, "country": null }, { "author_id": 237043, "given_name": "Christopher H", "family_name": "Hawkes", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": true, "ml_prediction_lr": false, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T05:53:16.260174Z", "noun_phrases": [ "multiple sclerosis", "a glymphaticopathy" ], "doi": "10.1016/j.msard.2023.105141", "access": "restricted", "takeaways": "", "categories": [] }, { "article_id": 166403, "title": "Exploratory 5-year follow-up study of retinol, tocopherols, and carotenoids in multiple sclerosis", "summary": "<div><p>Mult Scler Relat Disord. 2023 Nov 25;81:105143. doi: 10.1016/j.msard.2023.105143. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>BACKGROUND: Retinol, tocopherols, and carotenoids (RTC) have physiological roles as vitamins, pro-vitamins, and antioxidants, and provide biomarkers of dietary vegetable and fruit intake. The goal was to investigate RTC in multiple sclerosis (MS).</p><p>METHODS: This exploratory study included 106 people with MS (71 relapsing-remitting MS or RR-MS; and 35 progressive MS or PMS) and 31 healthy controls (HC) at baseline and 5-year follow-up (5YFU). Serum retinol, α-carotene, β-carotene, α-tocopherol, δ-tocopherol, γ-tocopherol, β-cryptoxanthin, lutein/zeaxanthin, and lycopene were measured using high performance liquid chromatography. Serum neurofilament light chain (sNfL) levels were measured using the single molecule array method. Expanded Disability Status Scale (EDSS) and low contrast letter acuity (LCLA) were used as disability measures.</p><p>RESULTS: Retinol in MS was positively correlated with α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and α-tocopherol but negatively correlated with δ-tocopherol. EDSS was associated with α-tocopherol, δ-tocopherol, and lycopene. Greater retinol levels were associated with greater LCLA in RR-MS and PMS; high contrast visual acuity was not associated. Greater γ-tocopherol levels were associated with lower LCLA and high contrast visual acuity in PMS.</p><p>CONCLUSIONS: RTC exhibit distinctive associations with LCLA and EDSS in MS.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38039941/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac\">38039941</a> | DOI:<a href=\"https://doi.org/10.1016/j.msard.2023.105143\">10.1016/j.msard.2023.105143</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38039941/?fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac", "published_date": "2023-12-01T11:00:00Z", "source": "PubMed", "publisher": "Multiple Sclerosis and Related Disorders", "container_title": "Multiple Sclerosis and Related Disorders", "authors": [ { "author_id": 336122, "given_name": "Nasim", "family_name": "Nehzat", "ORCID": null, "country": null }, { "author_id": 242404, "given_name": "Richard W.", "family_name": "Browne", "ORCID": null, "country": null }, { "author_id": 332011, "given_name": "Diala", "family_name": "Ghazal", "ORCID": null, "country": null }, { "author_id": 286185, "given_name": "Miriam", "family_name": "Tamaño-Blanco", "ORCID": null, "country": null }, { "author_id": 333785, "given_name": "Dejan", "family_name": "Jakimovski", "ORCID": null, "country": null }, { "author_id": 333784, "given_name": "Bianca", "family_name": "Weinstock-Guttman", "ORCID": null, "country": null }, { "author_id": 333783, "given_name": "Robert", "family_name": "Zivadinov", "ORCID": null, "country": null }, { "author_id": 336123, "given_name": "Murali", "family_name": "Ramanathan", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T05:53:12.633815Z", "noun_phrases": [ "Exploratory 5-year follow-up study", "retinol", "tocopherols", "carotenoids", "multiple sclerosis" ], "doi": "10.1016/j.msard.2023.105143", "access": "restricted", "takeaways": "Retinol, tocopherols, and carotenoids have physiological roles as vitamins, pro-vitamins, and antioxidants and provide biomarkers of dietary vegetable and fruit intake. The study included 106 people with MS, 71 relapsing-remitting MS, 35 progressive MS, and 31 healthy controls.", "categories": [] }, { "article_id": 166402, "title": "Latent tuberculosis infection in Korean patients with multiple sclerosis and neuromyelitis optica spectrum disorder", "summary": "<div><p>Mult Scler Relat Disord. 2023 Nov 21;81:105145. doi: 10.1016/j.msard.2023.105145. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>BACKGROUND: Latent tuberculosis infection (LTBI) is defined as an immune response to Mycobacterium tuberculosis infection that does not manifest clinically as active tuberculosis (TB). Since some immunotherapies can alter cellular immunity, LTBI screening has been recommended for patients with multiple sclerosis (pwMS) before initiation of long-term immunotherapies. In this study, we investigated the frequency of LTBI in Korean pwMS and patients with neuromyelitis optica spectrum disorder (pwNMOSD) and reported the long-term observation of untreated LTBI under various immunotherapies.</p><p>METHODS: We enrolled pwMS or pwNMOSD who visited the Neurology department of the National Cancer Center between 2017 and 2021. LTBI was determined based on positive results of interferon-gamma release assay (IGRA) using QuantiFERON Gold Plus test and no evidence of active TB. Annual chest X-ray and careful monitoring for TB symptoms were performed until April 2023 or the time of follow-up loss.</p><p>RESULTS: Among 531 patients who underwent the IGRA test, 25 pwMS (10.5%) and 42 pwNMOSD (14.3%) were diagnosed with LTBI. Of the 67 patients with LTBI, 59 patients (24 pwMS and 35 pwNMOSD) declined to receive preventive anti-TB drugs. None of the 59 with untreated LTBI demonstrated TB reactivation during 74.8 person-years in pwMS and 166.1 person-years in pwNMOSD. In addition, eight patients who completed the treatment for LTBI experienced no TB reactivation for a median of 5.5 years.</p><p>CONCLUSION: The LTBI prevalence in Korean pw MS and pwNMOSD was 10.5% and 14.3%, respectively, which was much higher than that in pwMS from Western countries. Notably, none of the 59 patients with untreated LTBI showed TB reactivation over 240 person-years even under long-term immunotherapies, indicating the need for additional research to stratify the risk of LTBI-reactivation.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38039942/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac\">38039942</a> | DOI:<a href=\"https://doi.org/10.1016/j.msard.2023.105145\">10.1016/j.msard.2023.105145</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38039942/?fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac", "published_date": "2023-12-01T11:00:00Z", "source": "PubMed", "publisher": "Multiple Sclerosis and Related Disorders", "container_title": "Multiple Sclerosis and Related Disorders", "authors": [ { "author_id": 336119, "given_name": "Ki Hoon", "family_name": "Kim", "ORCID": null, "country": null }, { "author_id": 336120, "given_name": "Su-Hyun", "family_name": "Kim", "ORCID": null, "country": null }, { "author_id": 247834, "given_name": "Na Young", "family_name": "Park", "ORCID": null, "country": null }, { "author_id": 322641, "given_name": "Min Jeong", "family_name": "Kim", "ORCID": null, "country": null }, { "author_id": 336121, "given_name": "Jae-Won", "family_name": "Hyun", "ORCID": null, "country": null }, { "author_id": 148923, "given_name": "Ho Jin", "family_name": "Kim", "ORCID": "http://orcid.org/0000-0002-8672-8419", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T05:53:08.974105Z", "noun_phrases": [ "Latent tuberculosis infection", "Korean patients", "multiple sclerosis and neuromyelitis optica spectrum disorder" ], "doi": "10.1016/j.msard.2023.105145", "access": "restricted", "takeaways": "Latent tuberculosis infection (LTBI) is an immune response to Mycobacterium tuberculosis infection that does not manifest clinically as active tuberculosis (TB). LTBI screening has been recommended for patients with multiple sclerosis (pwMS) before initiation of long-term immunotherapies. LTBI prevalence in Korean pwMS and pwNMOSD was 10.5% and 14.3%.", "categories": [] }, { "article_id": 166401, "title": "Multiple sclerosis disease-modifying drug use by immigrants: a real-world study", "summary": "<div><p>Sci Rep. 2023 Dec 1;13(1):21235. doi: 10.1038/s41598-023-46313-7.</p><p><b>ABSTRACT</b></p><p>Little is known about disease-modifying drug (DMD) initiation by immigrants with multiple sclerosis (MS) in countries with universal health coverage. We assessed the association between immigration status and DMD use within 5-years after the first MS-related healthcare encounter. Using health administrative data, we identified MS cases in British Columbia (BC), Canada. The index date was the first MS-related healthcare encounter (MS/demyelinating disease-related diagnosis or DMD prescription filled), and ranged from 01/January/1996 to 31/December/2012. Those included were ≥ 18 years old, BC residents for ≥ 1-year pre- and ≥ 5-years post-index date. Persons becoming permanent residents 1985-2012 were defined as immigrants, all others were long-term residents. The association between immigration status and any DMD prescription filled within 5-years post-index date (with the latest study end date being 31/December/2017) was assessed using logistic regression, reported as adjusted odds ratios (aORs) with 95% confidence intervals (CIs). We identified 8762 MS cases (522 were immigrants). Among immigrants of lower SES, odds of filling any DMD prescription were reduced, whereas they did not differ between immigrants and long-term residents across SES quintiles (aOR 0.96; 95%CI 0.78-1.19). Overall use (odds) of a first DMD within 5 years after the first MS-related encounter was associated with immigration status.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38040796/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac\">38040796</a> | DOI:<a href=\"https://doi.org/10.1038/s41598-023-46313-7\">10.1038/s41598-023-46313-7</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38040796/?fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac", "published_date": "2023-12-01T11:00:00Z", "source": "PubMed", "publisher": "Scientific Reports", "container_title": "Scientific Reports", "authors": [ { "author_id": 336117, "given_name": "Jonas", "family_name": "Graf", "ORCID": null, "country": null }, { "author_id": 336118, "given_name": "Huah Shin", "family_name": "Ng", "ORCID": null, "country": null }, { "author_id": 241013, "given_name": "Feng", "family_name": "Zhu", "ORCID": null, "country": null }, { "author_id": 247823, "given_name": "Yinshan", "family_name": "Zhao", "ORCID": null, "country": null }, { "author_id": 267893, "given_name": "José M. A.", "family_name": "Wijnands", "ORCID": null, "country": null }, { "author_id": 267896, "given_name": "Charity", "family_name": "Evans", "ORCID": null, "country": null }, { "author_id": 241803, "given_name": "John D.", "family_name": "Fisk", "ORCID": null, "country": null }, { "author_id": 333856, "given_name": "Ruth Ann", "family_name": "Marrie", "ORCID": null, "country": null }, { "author_id": 151868, "given_name": "Helen", "family_name": "Tremlett", "ORCID": "http://orcid.org/0000-0001-5804-2535", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T05:53:05.282483Z", "noun_phrases": [ "Multiple sclerosis disease-modifying drug use", "immigrants", "a real-world study" ], "doi": "10.1038/s41598-023-46313-7", "access": "open", "takeaways": "There are 8762 MS cases in British Columbia, Canada, of which 521 were immigrants. The index date was the first MS-related healthcare encounter (MS/demyelinating disease-related diagnosis or DMD prescription filled), and the index date ranged from 01/January/1996 to 31/December/2012. The association between immigration status and DMD use within 5-years post-index date was assessed.", "categories": [] }, { "article_id": 166400, "title": "Unfolding biographies-a participatory narrative study on how older adults with multiple sclerosis make sense of and manage their everyday lives", "summary": "<div><p>BMC Geriatr. 2023 Dec 1;23(1):794. doi: 10.1186/s12877-023-04504-x.</p><p><b>ABSTRACT</b></p><p>BACKGROUND: Today, public health research on later life, including the literature on aging with multiple sclerosis, is often centered on aging as a biological phenomenon. By applying a participatory narrative approach, this study conveys how studying biographical aging provides important insights into the elements of aging that people find relevant and meaningful. Based on narratives told by older adults living with multiple sclerosis, we explore how sensemaking unfolds and shapes the management of later life with a chronic and progressive disease.</p><p>METHODS: Twenty-four older adults (aged 65 years or older) living with multiple sclerosis in Denmark were engaged in taking photographs of their everyday lives and unfold the stories framed in their photographs in subsequent narrative interviews. Interview data were analyzed using a thematic narrative analysis. Aligned with the narrative approach, the findings of the analysis are presented using five cases chosen because they provide insight into the general patterns and themes identified across the narratives of the 24 participants.</p><p>RESULTS: Based on their photographs, the participants narrated stories centered around what they perceived as meaningful activities and social identity when aging with a progressive disease. Three themes emerged from the analysis in relation to how participants made sense of and managed aging with multiple sclerosis: 1) a life woven by non-detachable life experiences, 2) envisioning the future and 3) challenging life circumstances.</p><p>CONCLUSION: The findings of the study highlight that aging with multiple sclerosis is not only a biological phenomenon but also something nested in people's biographies. How people make sense of and manage their everyday lives is shaped by strategies from all parts of their lives-past, present and future. This understanding of later life with multiple sclerosis may enhance the care offered to older adults living with multiple sclerosis if greater emphasis is placed on the exploration of their narratives and the things they find meaningful.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/38041101/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac\">38041101</a> | DOI:<a href=\"https://doi.org/10.1186/s12877-023-04504-x\">10.1186/s12877-023-04504-x</a></p></div>", "link": "https://pubmed.ncbi.nlm.nih.gov/38041101/?fc=20210216052009&ff=20231202005259&v=2.17.9.post6+86293ac", "published_date": "2023-12-01T11:00:00Z", "source": "PubMed", "publisher": "BMC Geriatrics", "container_title": "BMC Geriatrics", "authors": [ { "author_id": 323363, "given_name": "Sofie Olsgaard", "family_name": "Bergien", "ORCID": null, "country": null }, { "author_id": 336116, "given_name": "Lasse", "family_name": "Skovgaard", "ORCID": null, "country": null }, { "author_id": 269143, "given_name": "Maria", "family_name": "Kristiansen", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T05:53:01.247418Z", "noun_phrases": [ "Unfolding biographies", "a participatory narrative study", "how older adults", "multiple sclerosis", "sense", "their everyday lives" ], "doi": "10.1186/s12877-023-04504-x", "access": "open", "takeaways": "Biographical aging provides important insights into elements of aging that people find relevant and meaningful. The literature on aging with multiple sclerosis is often centered on aging as a biological phenomenon. Twenty-four older adults (aged 65 years or older) living with Multiple Sclerosis in Denmark were asked to take photos of their everyday lives and narrate their stories.", "categories": [] }, { "article_id": 166097, "title": "Unfolding biographies—a participatory narrative study on how older adults with multiple sclerosis make sense of and manage their everyday lives", "summary": null, "link": "https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-023-04504-x", "published_date": "2023-12-01T00:00:00Z", "source": "BioMedCentral", "publisher": "Springer Science and Business Media LLC", "container_title": "BMC Geriatrics", "authors": [ { "author_id": 323363, "given_name": "Sofie Olsgaard", "family_name": "Bergien", "ORCID": null, "country": null }, { "author_id": 178907, "given_name": "Lasse", "family_name": "Skovgaard", "ORCID": "http://orcid.org/0000-0002-2439-2323", "country": null }, { "author_id": 269143, "given_name": "Maria", "family_name": "Kristiansen", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": null, "ml_prediction_lr": null, "ml_prediction_lsvc": null, "discovery_date": "2023-12-02T00:35:40.198410Z", "noun_phrases": [ "Unfolding biographies", "a participatory narrative study", "how older adults", "multiple sclerosis", "sense", "their everyday lives" ], "doi": "10.1186/s12877-023-04504-x", "access": "restricted", "takeaways": null, "categories": [] } ] }