List all articles in the database by descending article_id

GET /articles/
HTTP 200 OK
Allow: GET, POST, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept

{
    "count": 16566,
    "next": "http://api.gregory-ms.com/articles/?page=2",
    "previous": null,
    "results": [
        {
            "article_id": 1209171,
            "title": "The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored",
            "summary": "<jats:title>Abstract</jats:title><jats:p>Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new, effective therapeutic strategies. Amyloid beta oligomers and plaques, tau aggregates, and neuroinflammation play a critical role in neurodegeneration and impact clinical AD progression. The upstream modulators of these pathological features have not been fully clarified, but recent evidence indicates that the gut microbiome (GMB) may have an influence on these features and therefore may influence AD progression in human patients. In this review, we summarize studies that have identified alterations in the GMB that correlate with pathophysiology in AD patients and AD mouse models. Additionally, we discuss findings with GMB manipulations in AD models and potential GMB-targeted therapeutics for AD. Lastly, we discuss diet, sleep, and exercise as potential modifiers of the relationship between the GMB and AD and conclude with future directions and recommendations for further studies of this topic.</jats:p>",
            "link": "https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00595-7",
            "published_date": "2023-02-01T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Molecular Neurodegeneration",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/16992/",
                    "family_name": "Chandra",
                    "given_name": "Sidhanth",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86314/",
                    "family_name": "Sisodia",
                    "given_name": "Sangram S.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86315/",
                    "family_name": "Vassar",
                    "given_name": "Robert J.",
                    "ORCID": "http://orcid.org/0000-0002-1358-504X"
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T06:51:16.447035Z",
            "noun_phrases": [
                "The gut microbiome",
                "Alzheimer’s disease",
                "what",
                "we",
                "what"
            ],
            "doi": "10.1186/s13024-023-00595-7",
            "access": "open",
            "takeaways": " There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new therapeutic strategies . Recent evidence indicates that the gut microbiome (GMB) may have an influence on these features and therefore may influence AD progression in human patients ."
        },
        {
            "article_id": 1209140,
            "title": "Quantitative magnetic resonance imaging reflects different levels of histologically determined myelin densities in multiple sclerosis, including remyelination in inactive multiple sclerosis lesions",
            "summary": "<div><p>Brain Pathol. 2023 Jan 31:e13150. doi: 10.1111/bpa.13150. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>Magnetic resonance imaging (MRI) of focal or diffuse myelin damage or remyelination may provide important insights into disease progression and potential treatment efficacy in multiple sclerosis (MS). We performed post-mortem MRI and histopathological myelin measurements in seven progressive MS cases to evaluate the ability of three myelin-sensitive MRI scans to distinguish different stages of MS pathology, particularly chronic demyelinated and remyelinated lesions. At 3 Tesla, we acquired two different myelin water imaging (MWI) scans and magnetisation transfer ratio (MTR) data. Histopathology included histochemical stainings for myelin phospholipids (LFB) and iron as well as immunohistochemistry for myelin proteolipid protein (PLP), CD68 (phagocytosing microglia/macrophages) and BCAS1 (remyelinating oligodendrocytes). Mixed-effects modelling determined which histopathological metric best predicted MWF and MTR in normal-appearing and diffusely abnormal white matter, active/inactive, inactive, remyelinated and ischemic lesions. Both MWI measures correlated well with each other and histology across regions, reflecting the different stages of MS pathology. MTR data showed a considerable influence of components other than myelin and a strong dependency on tissue storage duration. Both MRI and histology revealed increased myelin densities in inactive compared with active/inactive lesions. Chronic inactive lesions harboured single scattered myelin fibres indicative of low-level remyelination. Mixed-effects modelling showed that smaller differences between white matter areas were linked to PLP densities and only to a small extent confounded by iron. MWI reflects differences in myelin lipids and proteins across various levels of myelin densities encountered in MS, including low-level remyelination in chronic inactive lesions.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36720269/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230201012014&amp;v=2.17.9.post6+86293ac\">36720269</a> | DOI:<a href=\"https://doi.org/10.1111/bpa.13150\">10.1111/bpa.13150</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36720269/?fc=20210216052009&ff=20230201012014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Brain Pathology",
            "container_title": "Brain Pathology",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/24080/",
                    "family_name": "Rauscher",
                    "given_name": "Alexander",
                    "ORCID": "http://orcid.org/0000-0002-1961-8252"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/78241/",
                    "family_name": "Hametner",
                    "given_name": "Simon",
                    "ORCID": "http://orcid.org/0000-0002-5160-5208"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86309/",
                    "family_name": "Wiggermann",
                    "given_name": "Vanessa",
                    "ORCID": "http://orcid.org/0000-0001-5236-3039"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86310/",
                    "family_name": "Endmayr",
                    "given_name": "Verena",
                    "ORCID": "http://orcid.org/0000-0001-5279-5720"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86311/",
                    "family_name": "Hernández‐Torres",
                    "given_name": "Enedino",
                    "ORCID": "http://orcid.org/0000-0003-2873-5693"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86312/",
                    "family_name": "Höftberger",
                    "given_name": "Romana",
                    "ORCID": "http://orcid.org/0000-0002-5769-1100"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86313/",
                    "family_name": "Kasprian",
                    "given_name": "Gregor",
                    "ORCID": "http://orcid.org/0000-0003-3858-3347"
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T06:20:38.092589Z",
            "noun_phrases": [
                "Quantitative magnetic resonance imaging",
                "different levels",
                "histologically determined myelin densities",
                "multiple sclerosis",
                "remyelination",
                "inactive multiple sclerosis lesions"
            ],
            "doi": "10.1111/bpa.13150",
            "access": "restricted",
            "takeaways": " Magnetic resonance imaging of focal or diffuse myelin damage or remyelination may provide important insights into disease progression and potential treatment efficacy in MS ."
        },
        {
            "article_id": 1209139,
            "title": "Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model",
            "summary": "<div><p>Biochem Pharmacol. 2023 Jan 28:115435. doi: 10.1016/j.bcp.2023.115435. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>There is vast evidence for the effect of NOD-like receptor protein-3 (NLRP3) inflammasome on multiple sclerosis (MS) pathogenesis. Clemastine (CLM) targets NLRP3 in hypoxic brain injury and promotes oligodendrocyte differentiation. However, no previous study pointed to the link of CLM with inflammasome components in MS. Herein, the study aimed to verify the action of CLM on NLRP3 signaling in experimental autoimmune encephalomyelitis (EAE) as an MS rat model. Homogenate of spinal cord with complete Freund's adjuvant was administered on days 0 and 7 to induce EAE. Rats received either CLM (5 mg/kg/day; p.o.) or MCC950 (2.5 mg/kg/day; i.p) for 15 days starting from the first immunization day. In EAEs' brains, NLRP3 pathway components; total and phosphorylated p38 mitogen-activated protein kinase (MAPK), apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1, interleukins 1β and -18 along with pyroptotic marker; gasdermin D (GSDMD) were upregulated. These were accompanied with diminished nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and total antioxidant capacity levels. CLM improved these perturbations as well as signs of MS; weight loss, clinical scores, and motor disorders observed in the open field, hanging wire and rotarod tests. Histopathological examinations revealed improvement in H&amp;E abnormalities and axonal demyelination as shown by luxol fast blue stain in lumbar sections of spinal cord. These CLM's actions were studied in comparison to MCC950 as a well-established selective blocker of the NLRP3 inflammasome. Conclusively, CLM has a protective role against neuroinflammation and demyelination in EAE via its anti-inflammatory and anti-pyroptotic actions.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36720356/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230201012014&amp;v=2.17.9.post6+86293ac\">36720356</a> | DOI:<a href=\"https://doi.org/10.1016/j.bcp.2023.115435\">10.1016/j.bcp.2023.115435</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36720356/?fc=20210216052009&ff=20230201012014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Biochemical Pharmacology",
            "container_title": "Biochemical Pharmacology",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/86304/",
                    "family_name": "Motawi",
                    "given_name": "Tarek K.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86305/",
                    "family_name": "El-Maraghy",
                    "given_name": "Shohda A.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86306/",
                    "family_name": "Kamel",
                    "given_name": "Ahmed S.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86307/",
                    "family_name": "Said",
                    "given_name": "Salma E.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86308/",
                    "family_name": "Kortam",
                    "given_name": "Mona A.",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T06:20:32.646015Z",
            "noun_phrases": [
                "p38 MAPK",
                "Nrf2",
                "neuroinflammatory and remyelinating characters",
                "Clemastine",
                "EAE",
                "rat model"
            ],
            "doi": "10.1016/j.bcp.2023.115435",
            "access": "restricted",
            "takeaways": " Clemastine (CLM) targets NLRP3 in hypoxic brain injury and promotes oligodendrocyte differentiation . No previous study pointed to link of CLM with inflammasome components in MS ."
        },
        {
            "article_id": 1209138,
            "title": "Multifaceted Analysis of Cerebrospinal Fluid and Serum from Progressive Multiple Sclerosis Patients: Potential Role of Vitamin C and Metal Ion Imbalance in the Divergence of Primary Progressive Multiple Sclerosis and Secondary Progressive Multiple Sclerosis",
            "summary": "<div><p>J Proteome Res. 2023 Jan 31. doi: 10.1021/acs.jproteome.2c00460. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>The progressive forms of multiple sclerosis (MS) primary progressive MS (PPMS) and secondary progressive MS (SPMS) are clinically distinguished by the rate at which symptoms worsen. Little is however known about the pathological mechanisms underlying the differential rate of accumulation of pathological changes. In this study, <sup>1</sup>H NMR spectroscopy was used to measure low-molecular-weight metabolites in paired cerebrospinal fluid (CSF) and serum of PPMS, SPMS, and control patients, as well as to determine lipoproteins and glycoproteins in serum samples. Additionally, neurodegenerative and inflammatory markers, neurofilament light (NFL) and chitinase-3-like protein 1 (CHI3L1), and the concentration of seven metal elements, Mg, Mn, Cu, Fe, Pb, Zn, and Ca, were also determined in both CSF and serum. The results indicate that the pathological changes associated with progressive MS are mainly localized in the central nervous system (CNS). More so, PPMS and SPMS patients with comparable disability status are pathologically similar in relation to neurodegeneration, neuroinflammation, and some metabolites that distinguish them from controls. However, the rapid progression of PPMS from the onset may be driven by a combination of neurotoxicity induced by heavy metals coupled with diminished CNS antioxidative capacity associated with differential intrathecal ascorbate retention and imbalance of Mg and Cu.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36720471/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230201012014&amp;v=2.17.9.post6+86293ac\">36720471</a> | DOI:<a href=\"https://doi.org/10.1021/acs.jproteome.2c00460\">10.1021/acs.jproteome.2c00460</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36720471/?fc=20210216052009&ff=20230201012014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Journal of Proteome Research",
            "container_title": "Journal of Proteome Research",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/2814/",
                    "family_name": "Eichau",
                    "given_name": "Sara",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86296/",
                    "family_name": "Pomary",
                    "given_name": "Precious Kwadzo",
                    "ORCID": "http://orcid.org/0000-0002-8447-4371"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86297/",
                    "family_name": "Amigó",
                    "given_name": "Núria",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86298/",
                    "family_name": "Barrios",
                    "given_name": "Laura",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86299/",
                    "family_name": "Matesanz",
                    "given_name": "Fuencisla",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86300/",
                    "family_name": "García-Valdecasas",
                    "given_name": "Marta",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86301/",
                    "family_name": "Hrom",
                    "given_name": "Ioana",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86302/",
                    "family_name": "García Sánchez",
                    "given_name": "María Isabel",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86303/",
                    "family_name": "Garcia-Martin",
                    "given_name": "Maria Luisa",
                    "ORCID": "http://orcid.org/0000-0002-2257-7682"
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T06:20:27.012757Z",
            "noun_phrases": [
                "Multifaceted Analysis",
                "Cerebrospinal Fluid",
                "Serum",
                "Progressive Multiple Sclerosis Patients",
                "Potential Role",
                "Vitamin C",
                "Metal Ion Imbalance",
                "the Divergence",
                "Primary Progressive Multiple Sclerosis",
                "Secondary Progressive Multiple Sclerosis"
            ],
            "doi": "10.1021/acs.jproteome.2c00460",
            "access": "restricted",
            "takeaways": " 1H NMR spectroscopy was used to measure low-molecular-weight metabolites in paired cerebrospinal fluid (CSF) and serum of PPMS, SPMS, and control patients . Neurodegenerative and inflammatory markers, neurofilament light (NFL) and chitinase-3-like protein 1 (CHI3L1) were also determined ."
        },
        {
            "article_id": 1209137,
            "title": "Volumetric changes in hypothalamic subunits in patients with relapsing remitting multiple sclerosis",
            "summary": "<div><p>Neuroradiology. 2023 Feb 1. doi: 10.1007/s00234-023-03122-z. Online ahead of print.</p><p><b>ABSTRACT</b></p><p>PURPOSE: Studies on hypothalamic changes in patients with relapsing remitting multiple sclerosis (RRMS) are very scarce, despite the fact that the relationship with the hypothalamus is frequently reported. The aim of the study was to determine the volume of the hypothalamic subunits and the total hypothalamus and its relationship with the total demyelinating lesion volume (TLV) and expanded disability status scale (EDSS) in RRMS patients.</p><p>METHODS: In this cross-sectional study, anterior-superior, superior tubular, posterior hypothalamus, anterior-inferior, inferior tubular subunits of hypothalamus, and total hypothalamus volume were calculated, with fully automatic analysis methods using volumetric T1 images of 65 relapsed RRMS patients and 68 healthy controls (HC). Volume changes in the hypothalamus and its subunits in RRMS patients were examined using multivariate analysis of covariance (MANCOVA). The relationship of these volumes with EDSS and TLV was investigated by partial correlation analysis.</p><p>RESULTS: There is volume reduction in total hypothalamus (F = 13.87, p &lt; 0.001), anterior-superior (F = 19.2, p &lt; 0.001), superior tubular (F = 10.1, p = 0.002) subunits, and posterior hypothalamus (F = 19.2, p &lt; 0.001) volume in RRMS patients. EDSS correlates negatively with anterior-superior (p = 0.017, r = - 0.333), superior tubular subunits (p = 0.023, r = - 0.439), posterior hypothalamus (p &lt; 0.001, r = - 0.511), and whole hypothalamus volume (p = 0.001, r = - 0.439). TLV correlates negatively with anterior superior (p &lt; 0.001, r = - 0.565), anterior inferior (p = 0.002, r = - 0.431), superior tubular subunits (p = 0.002, r = - 0.432), posterior hypothalamus (p &lt; 0.001, r = - 0.703), and whole hypothalamus (p &lt; 0.001, r = - 0.627) volumes.</p><p>CONCLUSION: This study demonstrates a reduction in total hypothalamus volume, anterior-superior, superior tubular, and posterior hypothalamus in patients with RRMS. Anterior-superior and superior tubular subunit, posterior hypothalamus, and total hypothalamus volume were negatively correlated with TLV and EDSS scores.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36720749/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230201012014&amp;v=2.17.9.post6+86293ac\">36720749</a> | DOI:<a href=\"https://doi.org/10.1007/s00234-023-03122-z\">10.1007/s00234-023-03122-z</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36720749/?fc=20210216052009&ff=20230201012014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Neuroradiology",
            "container_title": "Neuroradiology",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/86292/",
                    "family_name": "Genç",
                    "given_name": "Barış",
                    "ORCID": "http://orcid.org/0000-0003-3548-6373"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86293/",
                    "family_name": "Şen",
                    "given_name": "Sedat",
                    "ORCID": "http://orcid.org/0000-0001-8048-6845"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86294/",
                    "family_name": "Aslan",
                    "given_name": "Kerim",
                    "ORCID": "http://orcid.org/0000-0001-6322-7163"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86295/",
                    "family_name": "İncesu",
                    "given_name": "Lütfi",
                    "ORCID": "http://orcid.org/0000-0001-5071-566X"
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T06:20:21.604344Z",
            "noun_phrases": [
                "hypothalamic subunits",
                "patients",
                "multiple sclerosis"
            ],
            "doi": "10.1007/s00234-023-03122-z",
            "access": "restricted",
            "takeaways": " Studies on hypothalamic changes in patients with relapsing remitting multiple sclerosis (RRMS) are very scarce, despite the fact that the relationship with the hypothalamus is frequently reported . The aim of the study was to determine the volume of the hypothalamic subunits and the total hypothalamus ."
        },
        {
            "article_id": 1209136,
            "title": "Author Correction: Vitamin D status and severity of COVID-19",
            "summary": "<div><p>Sci Rep. 2023 Jan 31;13(1):1781. doi: 10.1038/s41598-023-28993-3.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36720914/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230201012014&amp;v=2.17.9.post6+86293ac\">36720914</a> | DOI:<a href=\"https://doi.org/10.1038/s41598-023-28993-3\">10.1038/s41598-023-28993-3</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36720914/?fc=20210216052009&ff=20230201012014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Scientific Reports",
            "container_title": "Scientific Reports",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/1124/",
                    "family_name": "Nielsen",
                    "given_name": "Nete Munk",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/1129/",
                    "family_name": "Ascherio",
                    "given_name": "Alberto",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/1130/",
                    "family_name": "Stenager",
                    "given_name": "Egon",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/45091/",
                    "family_name": "Munger",
                    "given_name": "Kassandra L.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/79412/",
                    "family_name": "Junker",
                    "given_name": "Thor Grønborg",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/79413/",
                    "family_name": "Cohen",
                    "given_name": "Arieh S.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/79414/",
                    "family_name": "Boding",
                    "given_name": "Lasse",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/79415/",
                    "family_name": "Hviid",
                    "given_name": "Anders",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86291/",
                    "family_name": "Boelt",
                    "given_name": "Sanne Grundvad",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T06:20:16.053502Z",
            "noun_phrases": [
                "Author Correction",
                "Vitamin D status",
                "severity",
                "COVID-19"
            ],
            "doi": "10.1038/s41598-023-28993-3",
            "access": "restricted",
            "takeaways": ""
        },
        {
            "article_id": 1209065,
            "title": "CD146 expression profile in human skin and pre-vascularized dermo-epidermal skin substitutes in vivo",
            "summary": null,
            "link": "https://jbioleng.biomedcentral.com/articles/10.1186/s13036-023-00327-x",
            "published_date": "2023-01-31T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Biological Engineering",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/28465/",
                    "family_name": "Nanni",
                    "given_name": "Monica",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86280/",
                    "family_name": "Rütsche",
                    "given_name": "Dominic",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86281/",
                    "family_name": "Bächler",
                    "given_name": "Curdin",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86282/",
                    "family_name": "Pontiggia",
                    "given_name": "Luca",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86283/",
                    "family_name": "Klar",
                    "given_name": "Agnes S.",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86284/",
                    "family_name": "Moehrlen",
                    "given_name": "Ueli",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86285/",
                    "family_name": "Biedermann",
                    "given_name": "Thomas",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": null,
            "ml_prediction_lr": null,
            "discovery_date": "2023-02-01T04:51:34.529011Z",
            "noun_phrases": [
                "CD146 expression profile",
                "human skin",
                "pre-vascularized dermo-epidermal skin substitutes",
                "vivo"
            ],
            "doi": "10.1186/s13036-023-00327-x",
            "access": "restricted",
            "takeaways": null
        },
        {
            "article_id": 1208784,
            "title": "Learning multiple sclerosis immunopathogenesis from anti-CD20 therapy",
            "summary": "<div><p>Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2221544120. doi: 10.1073/pnas.2221544120. Epub 2023 Jan 31.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36719925/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230131191014&amp;v=2.17.9.post6+86293ac\">36719925</a> | DOI:<a href=\"https://doi.org/10.1073/pnas.2221544120\">10.1073/pnas.2221544120</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36719925/?fc=20210216052009&ff=20230131191014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Proceedings of the National Academy of Sciences",
            "container_title": "Proceedings of the National Academy of Sciences",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/37846/",
                    "family_name": "Heming",
                    "given_name": "Michael",
                    "ORCID": "http://orcid.org/0000-0002-9568-2790"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/77535/",
                    "family_name": "Wiendl",
                    "given_name": "Heinz",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-02-01T00:10:15.573212Z",
            "noun_phrases": [
                "multiple sclerosis immunopathogenesis",
                "anti-CD20 therapy"
            ],
            "doi": "10.1073/pnas.2221544120",
            "access": "restricted",
            "takeaways": ""
        },
        {
            "article_id": 1208502,
            "title": "Effect of a computerized decision support system on the treatment approach of stage III or IV pressure injury in patients with spinal cord injury: a feasibility study",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n<jats:title>Background</jats:title>\n<jats:p>Stage III and IV pressure injuries (PIs) in patients with spinal cord injury (SCI) require complex interdisciplinary and interprofessional treatment approaches that are difficult to implement. Practical aspects, such as information exchange and coordination, remain challenging. We investigated whether a computerized decision support system (CDSS) could increase treatment adherence and improve clinical outcomes and interprofessional collaboration.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Method</jats:title>\n<jats:p>In this feasibility study, a core team developed the initial treatment process and adapted it based on several discussions with clinical experts and information technologists. The CDSS followed the Basel Decubitus Approach and was used in a clinic specializing in SCI. Thirty patients with SCI admitted for stage III/IV PI between July 2016 and May 2017 were randomly allocated to standard or CDSS-supported care. Between-group differences in treatment adherence, complication rates, length of stay, and costs were analyzed using descriptive statistics. The use of the CDSS and potential barriers and facilitators were evaluated through interprofessional focus groups, transcribed verbatim, and thematically analyzed (30 participants).</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Results</jats:title>\n<jats:p>No differences in SCI characteristics, comorbidities, or PI characteristics (localization: ischium [number (n) = 19 PI, 63%], sacrum [<jats:italic>n</jats:italic> = 10 PI, 33%], recurrent PI [<jats:italic>n</jats:italic> = 21, 70%]) were found between the two groups. Furthermore, no statistically significant differences were observed in treatment adherence, frequency of major (20% vs. 13% between CDSS and control group) and minor (33% vs 27%) complications, and length of stay (98 [±28] vs 81 [±23] days). Healthcare professionals found the CDSS to be helpful for visualizing the treatment process. However, the high workload and difficulties in the information technology processes, such as missing reminders, slow computer performance and data processing, and poor accessibility, hindered the effective implementation of the CDSS.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Conclusion</jats:title>\n<jats:p>The implementation of the CDSS to support the treatment of stage III/IV PI in patients with SCI was feasible and included definitions of milestones, interventions, and outcomes. However, to assess the impact of the CDSS, a longer observation period is required. Further, the technical difficulties must be addressed, and solid integration of the CDSS into the clinical information system is necessary.</jats:p>\n</jats:sec><jats:sec>\n<jats:title>Trial Registration</jats:title>\n<jats:p>This quality improvement project received a declaration of no objection from the Ethics Committee of Northwest and Central Switzerland (EKNZ UBE-16/003), and ethical approval was received for the focus groups (EKNZ Req-2017-00860).</jats:p>\n</jats:sec>",
            "link": "https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-023-09045-y",
            "published_date": "2023-01-31T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "BMC Health Services Research",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/86247/",
                    "family_name": "Scheel-Sailer",
                    "given_name": "Anke",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86248/",
                    "family_name": "Koligi",
                    "given_name": "Kamran",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86249/",
                    "family_name": "Lampart",
                    "given_name": "Patricia",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86250/",
                    "family_name": "Fähndrich",
                    "given_name": "Carina",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86251/",
                    "family_name": "Gmünder",
                    "given_name": "Hans Peter",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86252/",
                    "family_name": "Metzger",
                    "given_name": "Stefan",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86253/",
                    "family_name": "Schaefer",
                    "given_name": "Dirk",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86254/",
                    "family_name": "Schmitt",
                    "given_name": "Klaus",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86255/",
                    "family_name": "Stalder",
                    "given_name": "Stefan",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86256/",
                    "family_name": "Wettstein",
                    "given_name": "Reto",
                    "ORCID": null
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86257/",
                    "family_name": "Gemperli",
                    "given_name": "Armin",
                    "ORCID": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-01-31T18:51:15.439997Z",
            "noun_phrases": [
                "Effect",
                "a computerized decision support system",
                "the treatment approach",
                "stage III or IV pressure injury",
                "patients",
                "spinal cord injury",
                "a feasibility study"
            ],
            "doi": "10.1186/s12913-023-09045-y",
            "access": "open",
            "takeaways": null
        },
        {
            "article_id": 1208436,
            "title": "Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study",
            "summary": "<div><p>Yonsei Med J. 2023 Feb;64(2):133-138. doi: 10.3349/ymj.2022.0451.</p><p><b>ABSTRACT</b></p><p>PURPOSE: To examine the refractive errors, retinal manifestations, and genotype in tuberous sclerosis complex (TSC) patients in a Korean population.</p><p>MATERIALS AND METHODS: A total of 98 patients with TSC were enrolled in Severance Hospital for a retrospective cohort study. The number of retinal astrocytic hamartoma and retinal achromic patch within a patient, as well as the size, bilaterality, and morphological type were studied. In addition, the refractive status of patients and the comorbidity of intellectual disability and epilepsy were also examined.</p><p>RESULTS: Retinal astrocytic hamartoma was found in 37 patients, and bilateral invasion was observed in 20 patients (54%). TSC1 mutation was associated with myopia (<i>p</i>=0.01), while TSC2 mutation was associated with emmetropia (<i>p</i>=0.01). Retinal astrocytic hamartoma was categorized into three morphological types and examined as follows: type I (87%), type II (35%), and type III (14%). Single invasion of retinal astrocytic hamartoma was identified in 32% of the patients, and multiple invasions in 68%. The TSC1/TSC2 detection rate was 91% (41/45). Among them, TSC1 variant was detected in 23 patients (54%), whereas TSC2 variant was detected in 18 patients (40%). The results showed that TSC2 mutations are correlated with a higher rate of retinal astrocytic hamartoma involvement (all <i>p</i>&lt;0.05), and multiple and bilateral involvement of retinal hamartomas (all <i>p</i>&lt;0.05). However, the size of retinal astrocytic hamartomas, comorbidity of epilepsy, or intellectual disability did not show correlation with the genetic variant.</p><p>CONCLUSION: TSC1 variant patients were more myopic, while TSC2 variant patients showed association with more extensive involvement of retinal astrocytic hamartoma.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/36719021/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20230131130014&amp;v=2.17.9.post6+86293ac\">36719021</a> | DOI:<a href=\"https://doi.org/10.3349/ymj.2022.0451\">10.3349/ymj.2022.0451</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/36719021/?fc=20210216052009&ff=20230131130014&v=2.17.9.post6+86293ac",
            "published_date": "2023-01-31T11:00:00Z",
            "source": "PubMed",
            "publisher": "Yonsei Medical Journal",
            "container_title": "Yonsei Medical Journal",
            "authors": [
                {
                    "url": "http://api.gregory-ms.com/authors/86241/",
                    "family_name": "Ryu",
                    "given_name": "Soyoung",
                    "ORCID": "http://orcid.org/0000-0002-1278-9024"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86242/",
                    "family_name": "Kang",
                    "given_name": "Hoon-Chul",
                    "ORCID": "http://orcid.org/0000-0002-3659-8847"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86243/",
                    "family_name": "Lee",
                    "given_name": "Sung Chul",
                    "ORCID": "http://orcid.org/0000-0001-9438-2385"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86244/",
                    "family_name": "Byeon",
                    "given_name": "Suk Ho",
                    "ORCID": "http://orcid.org/0000-0001-8101-0830"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86245/",
                    "family_name": "Kim",
                    "given_name": "Sung Soo",
                    "ORCID": "http://orcid.org/0000-0003-3049-9554"
                },
                {
                    "url": "http://api.gregory-ms.com/authors/86246/",
                    "family_name": "Lee",
                    "given_name": "Christopher Seungkyu",
                    "ORCID": "http://orcid.org/0000-0001-5054-9470"
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "discovery_date": "2023-01-31T18:00:33.760599Z",
            "noun_phrases": [
                "Refractive Errors",
                "Retinal Findings",
                "Genotype",
                "Tuberous Sclerosis Complex",
                "A Retrospective Cohort Study"
            ],
            "doi": "10.3349/ymj.2022.0451",
            "access": "open",
            "takeaways": " The number of retinal astrocytic hamartoma and retinal achromic patch within a patient, as well as the size, bilaterality, and morphological type were studied . TSC1 mutation was associated with myopia, while TSC2 mutation associated with emmetropia ."
        }
    ]
}