List all articles in the database by earliest discovery_date

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    "count": 26469,
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        {
            "article_id": 285834,
            "title": "Mild Systemic Inflammation Increases Erythrocyte Fragility",
            "summary": "<jats:p>There is growing evidence that inflammation impairs erythrocyte structure and function. We assessed the impact of mild systemic inflammation on erythrocyte fragility in three different settings. In order to investigate causation, erythrocyte osmotic fragility was measured in mice challenged with a live attenuated bacterial strain to induce low-grade systemic inflammation; a significant increase in erythrocyte osmotic fragility was observed. To gather evidence that systemic inflammation is associated with erythrocyte fragility in humans, two observational studies were conducted. First, using a retrospective study design, the relationship between reticulocyte-based surrogate markers of haemolysis and high-sensitivity C-reactive protein was investigated in 9292 healthy participants of the UK Biobank project. Secondly, we prospectively assessed the relationship between systemic inflammation (measured by the urinary neopterin/creatinine ratio) and erythrocyte osmotic fragility in a mixed population (n = 54) of healthy volunteers and individuals with long-term medical conditions. Both human studies were in keeping with a relationship between inflammation and erythrocyte fragility. Taken together, we conclude that mild systemic inflammation increases erythrocyte fragility and may contribute to haemolysis. Further research is needed to assess the molecular underpinnings of this pathway and the clinical implications in inflammatory conditions.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000133/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359746,
                    "given_name": "Charlotte M.",
                    "family_name": "Stuart",
                    "ORCID": "http://orcid.org/0000-0002-5779-5487",
                    "country": null
                },
                {
                    "author_id": 359747,
                    "given_name": "Carmen",
                    "family_name": "Jacob",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 218211,
                    "given_name": "Aravinthan",
                    "family_name": "Varatharaj",
                    "ORCID": "http://orcid.org/0000-0003-1629-5774",
                    "country": "GB"
                },
                {
                    "author_id": 359748,
                    "given_name": "Sarah",
                    "family_name": "Howard",
                    "ORCID": "http://orcid.org/0000-0002-8161-3014",
                    "country": null
                },
                {
                    "author_id": 359749,
                    "given_name": "Joe K.",
                    "family_name": "Chouhan",
                    "ORCID": "http://orcid.org/0000-0002-8067-5352",
                    "country": null
                },
                {
                    "author_id": 359750,
                    "given_name": "Jessica L.",
                    "family_name": "Teeling",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 210902,
                    "given_name": "Ian",
                    "family_name": "Galea",
                    "ORCID": "http://orcid.org/0000-0002-1268-5102",
                    "country": "GB"
                }
            ],
            "discovery_date": "2024-07-13T23:28:27.541076Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137027",
            "access": "open",
            "takeaways": "There is growing evidence that inflammation impairs erythrocyte structure and function. In mice challenged with a live attenuated bacterial strain to induce low-grade systemic inflammation, there was a significant increase in erythrocyte osmotic fragility. The relationship between reticulocyte-based surrogate markers of haemolysis and high-sensitivity C-reactive protein was investigated in 9292 healthy participants of the UK Bi",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285833,
            "title": "Extracellular Vesicles as Mediators of Neuroinflammation in Intercellular and Inter-Organ Crosstalk",
            "summary": "<jats:p>Neuroinflammation, crucial in neurological disorders like Alzheimer’s disease, multiple sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular vesicles (EVs) play a pivotal role in intercellular and inter-organ communication, influencing disease progression. EVs serve as key mediators in the immune system, containing molecules capable of activating molecular pathways that exacerbate neuroinflammatory processes in neurological disorders. However, EVs from mesenchymal stem cells show promise in reducing neuroinflammation and cognitive deficits. EVs can cross CNS barriers, and peripheral immune signals can influence brain function via EV-mediated communication, impacting barrier function and neuroinflammatory responses. Understanding EV interactions within the brain and other organs could unveil novel therapeutic targets for neurological disorders.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000150/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359745,
                    "given_name": "Andrea",
                    "family_name": "Cabrera-Pastor",
                    "ORCID": "http://orcid.org/0000-0002-0729-1045",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:26.389893Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137041",
            "access": "open",
            "takeaways": "Neuroinflammation is crucial in neurological disorders like Alzheimer’s disease, multiple sclerosis, and hepatic encephalopathy. Extracellular vesicles play a pivotal role in intercellular and inter-organ communication. Understanding EV interactions within the",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285832,
            "title": "Anti-Neuroinflammatory Effects of a Novel Bile Acid Derivative",
            "summary": "<jats:p>In the search for novel potent immunomodulatory nuclear factor-erythroid 2 related factor 2 (Nrf2) activators, a derivative of cholic bile acid, SB140, was synthesized. The synthesis of SB140 aimed to increase the electrophilic functionality of the compound, enhancing its ability to activate Nrf2. Effects of SB140 on microglial cells, myeloid-derived cells (MDC), and T cells were explored in the context of (central nervous system) CNS autoimmunity. SB140 potently activated Nrf2 signaling in MDC and microglia. It was efficient in reducing the ability of microglial cells to produce inflammatory nitric oxide, interleukin (IL)-6, and tumor necrosis factor (TNF). Also, SB140 reduced the proliferation of encephalitogenic T cells and the production of their effector cytokines: IL-17 and interferon (IFN)-γ. On the contrary, the effects of SB140 on anti-inflammatory IL-10 production in microglial and encephalitogenic T cells were limited or absent. These results show that SB140 is a potent Nrf2 activator, as well as an immunomodulatory compound. Thus, further research on the application of SB140 in the treatment of neuroinflammatory diseases is warranted. Animal models of multiple sclerosis and other inflammatory neurological disorders will be a suitable choice for such studies.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000243/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
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                        3
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359742,
                    "given_name": "Srđan",
                    "family_name": "Bjedov",
                    "ORCID": "http://orcid.org/0000-0002-9630-5831",
                    "country": null
                },
                {
                    "author_id": 246543,
                    "given_name": "Goran",
                    "family_name": "Stegnjaić",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359743,
                    "given_name": "Suzana",
                    "family_name": "Stanisavljević",
                    "ORCID": "http://orcid.org/0000-0003-0781-8828",
                    "country": null
                },
                {
                    "author_id": 246541,
                    "given_name": "Milica",
                    "family_name": "Lazarević",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269258,
                    "given_name": "Ivan",
                    "family_name": "Pilipović",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359744,
                    "given_name": "Marija",
                    "family_name": "Sakač",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 168185,
                    "given_name": "Đorđe",
                    "family_name": "Miljković",
                    "ORCID": "http://orcid.org/0000-0002-5613-9306",
                    "country": "RS"
                }
            ],
            "discovery_date": "2024-07-13T23:28:24.749163Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137136",
            "access": "open",
            "takeaways": "SB140 is a potent Nrf2 activator and immunomodulatory compound. It is effective in reducing the ability of microglial cells to produce inflammatory nitric oxide, interleukin (IL)-6), tumor necrosis factor (TNF), IL-17 and IFN-γ. It also reduced the proliferation of encephalitogenic T cells. The effects of SB140 on anti-inflammatory IL-10 production in",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285831,
            "title": "The Role of miR-137 in Neurodegenerative Disorders",
            "summary": "<jats:p>Neurodegenerative diseases affect an increasing part of the population of modern societies, burdening healthcare systems and causing immense suffering at the personal level. The pathogenesis of several of these disorders involves dysregulation of gene expression, which depends on several molecular processes ranging from transcription to protein stability. microRNAs (miRNAs) are short non-coding RNA molecules that modulate gene expression by suppressing the translation of partially complementary mRNAs. miR-137 is a conserved, neuronally enriched miRNA that is implicated in neurodegeneration. Here, we review the current body of knowledge about the role that miR-137 plays in five prominent neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. The presented data indicate that, rather than having a general neuroprotective role, miR-137 modulates the pathology of distinct disorders differently.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000336/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
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                        3
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                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359737,
                    "given_name": "László",
                    "family_name": "Bodai",
                    "ORCID": "http://orcid.org/0000-0001-8411-626X",
                    "country": null
                },
                {
                    "author_id": 359738,
                    "given_name": "Roberta",
                    "family_name": "Borosta",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359739,
                    "given_name": "Ágnes",
                    "family_name": "Ferencz",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359740,
                    "given_name": "Mercédesz",
                    "family_name": "Kovács",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359741,
                    "given_name": "Nóra",
                    "family_name": "Zsindely",
                    "ORCID": "http://orcid.org/0000-0002-6189-3100",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:23.127876Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137229",
            "access": "open",
            "takeaways": "Neurodegenerative diseases affect an increasing part of the population. Pathogenesis of several of these disorders involves dysregulation of gene expression. miR-137 is a conserved, neuronally enriched miRNA that is implicated in neurodegeneration.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285830,
            "title": "Current Knowledge about Nonclassical Monocytes in Patients with Multiple Sclerosis, a Systematic Review",
            "summary": "<jats:p>Monocytes play a critical role in the initiation and progression of multiple sclerosis (MS). Recent research indicates the importance of considering the roles of monocytes in the management of MS and the development of effective interventions. This systematic review examined published research on the roles of nonclassical monocytes in MS and how they influence disease management. Reputable databases, such as PubMed, EMBASE, Cochrane, and Google Scholar, were searched for relevant studies on the influence of monocytes on MS. The search focused on studies on humans and patients with experimental autoimmune encephalomyelitis (EAE) published between 2014 and 2024 to provide insights into the study topic. Fourteen articles that examined the role of monocytes in MS were identified; the findings reported in these articles revealed that nonclassical monocytes could act as MS biomarkers, aid in the development of therapeutic interventions, reveal disease pathology, and improve approaches for monitoring disease progression. This review provides support for the consideration of monocytes when researching effective diagnostics, therapeutic interventions, and procedures for managing MS pathophysiology. These findings may guide future research aimed at gaining further insights into the role of monocytes in MS.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000478/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
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                        3
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 202465,
                    "given_name": "Borros M",
                    "family_name": "Arneth",
                    "ORCID": "http://orcid.org/0000-0002-9793-0970",
                    "country": "DE"
                }
            ],
            "discovery_date": "2024-07-13T23:28:20.870614Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137372",
            "access": "open",
            "takeaways": "Monocytes play a critical role in the initiation and progression of multiple sclerosis (MS). This systematic review examined published research on the roles of nonclassical monocytes in MS and how they influence disease management. It found that monocytes could act as MS biomarkers and aid in the development of therapeutic interventions.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285829,
            "title": "Cytokine Profiling in Cerebrospinal Fluid of Patients with Newly Diagnosed Relapsing-Remitting Multiple Sclerosis (RRMS): Associations between Inflammatory Biomarkers and Disease Activity",
            "summary": "<jats:p>Cytokines regulate immune responses and are crucial to MS pathogenesis. This study evaluated pro-inflammatory and anti-inflammatory cytokine concentrations in the CSF of de novo diagnosed RRMS patients compared to healthy controls. We assessed cytokine levels in the CSF of 118 de novo diagnosed RRMS patients and 112 controls, analyzing relationships with time from symptom onset to diagnosis, MRI lesions, and serum vitamin D levels. Elevated levels of IL-2, IL-4, IL-6, IL-13, FGF-basic, and GM-CSF, and lower levels of IL-1β, IL-1RA, IL-5, IL-7, IL-9, IL-10, IL-12p70, IL-15, G-CSF, PDGF-bb, and VEGF were observed in RRMS patients compared to controls. IL-2, IL-4, IL-12p70, PDGF, G-CSF, GM-CSF, and FGF-basic levels increased over time, while IL-10 decreased. IL-1β, IL-1RA, IL-6, TNF-α, and PDGF-bb levels negatively correlated with serum vitamin D. TNF-α levels positively correlated with post-contrast-enhancing brain lesions. IL-15 levels negatively correlated with T2 and Gd(+) lesions in C-spine MRI, while TNF-α, PDGF-bb, and FGF-basic correlated positively with T2 lesions in C-spine MRI. IL-6 levels positively correlated with post-contrast-enhancing lesions in Th-spine MRI. Distinct cytokine profiles in the CSF of de novo diagnosed MS patients provide insights into MS pathogenesis and guide immunomodulatory therapy strategies.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000506/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359735,
                    "given_name": "Barbara",
                    "family_name": "Gębka-Kępińska",
                    "ORCID": "http://orcid.org/0000-0002-0287-8031",
                    "country": null
                },
                {
                    "author_id": 335178,
                    "given_name": "Bożena",
                    "family_name": "Adamczyk",
                    "ORCID": "http://orcid.org/0000-0003-1641-5350",
                    "country": "PL"
                },
                {
                    "author_id": 359736,
                    "given_name": "Dorota",
                    "family_name": "Gębka",
                    "ORCID": "http://orcid.org/0000-0002-2439-0360",
                    "country": null
                },
                {
                    "author_id": 335184,
                    "given_name": "Zenon",
                    "family_name": "Czuba",
                    "ORCID": "http://orcid.org/0000-0001-8216-4495",
                    "country": "PL"
                },
                {
                    "author_id": 349172,
                    "given_name": "Jarosław",
                    "family_name": "Szczygieł",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 164717,
                    "given_name": "Monika",
                    "family_name": "Adamczyk-Sowa",
                    "ORCID": "http://orcid.org/0000-0002-6894-9891",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:19.228969Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137399",
            "access": "open",
            "takeaways": "Cytokines regulate immune responses and are crucial to MS pathogenesis. This study evaluated pro-inflammatory and anti-inflammatory cytokine concentrations in the CSF of de novo diagnosed RRMS patients compared to healthy controls.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285828,
            "title": "CCR5 Δ32 and CTLA-4 +49 A/G Gene Polymorphisms and Interferon-β Treatment Response in Croatian and Slovenian Multiple Sclerosis Patients",
            "summary": "<jats:p>The aim of the present study was to investigate the impact of CCR5 Δ32 and CTLA-4 polymorphisms on the response to IFN-β treatment in our cohort of MS patients from Croatia and Slovenia. Genomic DNA was obtained from 295 MS patients (230 female; 65 male) classified as responders (n = 173) and non-responders (n = 122) based on clinical criteria for treatment efficacy. Genotyping was performed via PCR/PCR-RFLP. No significant differences in the genotype/allele frequencies of CCR5Δ32 and CTLA-4 +49 A/G were detected between male responders and non-responders. A significantly higher prevalence (p = 0.039) of the CTLA-4 +49 AA genotype was found in female responders (42.1%) compared to non-responders (28.9%). Using multiple forward regression analysis, the CTLA-4 +49 AA genotype significantly predicted a positive response to IFN-β therapy in females (p = 0.011) and contributed to 4.5% of response variability. Furthermore, the combined presence of the CCR5Δ32 wtwt/CTLA-4 +49 AA genotype significantly predicted a positive response to treatment in females (p = 0.025). The age at disease onset, pretreatment relapse rate, and baseline EDSS score were not reliable predictors of treatment response in MS patients. Our results indicate that the presence of the CCR5Δ32 polymorphism was not associated with the response to IFN-β treatment, whereas the CTLA-4 +49 polymorphism showed a positive correlation with an optimal response in female patients.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000519/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359728,
                    "given_name": "Jasna",
                    "family_name": "Nekić",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359729,
                    "given_name": "Ivana",
                    "family_name": "Stanković Matić",
                    "ORCID": "http://orcid.org/0009-0005-8630-8704",
                    "country": null
                },
                {
                    "author_id": 150214,
                    "given_name": "Valentino",
                    "family_name": "Rački",
                    "ORCID": "http://orcid.org/0000-0003-3246-0506",
                    "country": "HR"
                },
                {
                    "author_id": 359730,
                    "given_name": "Dolores",
                    "family_name": "Janko Labinac",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359731,
                    "given_name": "Vladimira",
                    "family_name": "Vuletić",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359732,
                    "given_name": "Miljenko",
                    "family_name": "Kapović",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359733,
                    "given_name": "Smiljana",
                    "family_name": "Ristić",
                    "ORCID": "http://orcid.org/0000-0002-5484-6445",
                    "country": null
                },
                {
                    "author_id": 359734,
                    "given_name": "Borut",
                    "family_name": "Peterlin",
                    "ORCID": "http://orcid.org/0000-0001-7824-4978",
                    "country": null
                },
                {
                    "author_id": 275708,
                    "given_name": "Nada",
                    "family_name": "Starčević Čizmarević",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:17.534241Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137412",
            "access": "open",
            "takeaways": "Genomic DNA was obtained from 295 MS patients from Croatia and Slovenia. They were classified as responders (173) and non-responders (122) based on clinical criteria for treatment efficacy. The CTLA-4 +49 AA genotype significantly predicted a positive response to IFN-β therapy in females.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285827,
            "title": "Synergistic Targeting of Innate Receptors TLR7 and NOD2 for Therapeutic Intervention in Multiple Sclerosis",
            "summary": "<jats:p>Regulation of neuroinflammation is critical for maintaining central nervous system (CNS) homeostasis and holds therapeutic promise in autoimmune diseases such as multiple sclerosis (MS). Previous studies have highlighted the significance of selective innate signaling in triggering anti-inflammatory mechanisms, which play a protective role in an MS-like disease, experimental autoimmune encephalomyelitis (EAE). However, the individual intra-CNS administration of specific innate receptor ligands or agonists, such as for toll-like receptor 7 (TLR7) and nucleotide-binding oligomerization-domain-containing protein 2 (NOD2), failed to elicit the desired anti-inflammatory response in EAE. In this study, we investigated the potential synergistic effect of targeting both TLR7 and NOD2 simultaneously to prevent EAE progression. Our findings demonstrate that simultaneous intrathecal administration of NOD2- and TLR7-agonists led to synergistic induction of Type I IFN (IFN I) and effectively suppressed EAE in an IFN I-dependent manner. Suppression of EAE was correlated with a significant decrease in the infiltration of monocytes, granulocytes, and natural killer cells, reduced demyelination, and downregulation of IL-1β, CCL2, and IFNγ gene expression in the spinal cord. These results underscore the therapeutic promise of concurrently targeting the TLR7 and NOD2 pathways in alleviating neuroinflammation associated with MS, paving the way for novel and more efficacious treatment strategies.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39000569/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 359717,
                    "given_name": "Magdalena",
                    "family_name": "Dubik",
                    "ORCID": "http://orcid.org/0000-0002-4521-0410",
                    "country": null
                },
                {
                    "author_id": 359718,
                    "given_name": "Joanna",
                    "family_name": "Marczynska-Grzelak",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 262098,
                    "given_name": "Michael Zaucha",
                    "family_name": "Sørensen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 262095,
                    "given_name": "Ruthe Storgaard",
                    "family_name": "Dieu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359719,
                    "given_name": "Dominika",
                    "family_name": "Rusin",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359720,
                    "given_name": "Eydís Sigurdardóttir",
                    "family_name": "Schiöth",
                    "ORCID": "http://orcid.org/0009-0000-0331-648X",
                    "country": null
                },
                {
                    "author_id": 359721,
                    "given_name": "Bita",
                    "family_name": "Ramazani",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359722,
                    "given_name": "Rouhin",
                    "family_name": "Belal",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359723,
                    "given_name": "Bhavya",
                    "family_name": "Ojha",
                    "ORCID": "http://orcid.org/0000-0003-4919-6836",
                    "country": null
                },
                {
                    "author_id": 359724,
                    "given_name": "Jonathan",
                    "family_name": "Krieger",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359725,
                    "given_name": "Dina S.",
                    "family_name": "Arengoth",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359726,
                    "given_name": "Agnieszka",
                    "family_name": "Wlodarczyk",
                    "ORCID": "http://orcid.org/0000-0003-4123-368X",
                    "country": null
                },
                {
                    "author_id": 235468,
                    "given_name": "Trevor",
                    "family_name": "Owens",
                    "ORCID": "http://orcid.org/0000-0001-9315-6036",
                    "country": null
                },
                {
                    "author_id": 359727,
                    "given_name": "Reza",
                    "family_name": "Khorooshi",
                    "ORCID": "http://orcid.org/0000-0002-6164-4972",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:15.010057Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25137462",
            "access": "open",
            "takeaways": "Neuroinflammation is critical for maintaining central nervous system (CNS) homeostasis and holds therapeutic promise in autoimmune diseases such as multiple sclerosis. Previous studies have highlighted the significance of selective innate signaling in triggering anti-inflammatory mechanisms. In this study, we investigated the potential synergistic effect of targeting both TLR7 and NOD2 simultaneously to prevent EAE progression.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285826,
            "title": "A Comparison of Phenolic, Flavonoid, and Amino Acid Compositions and In Vitro Antioxidant and Neuroprotective Activities in Thai Plant Protein Extracts",
            "summary": "<jats:p>The leaves of mulberry, Azolla spp., sunflower sprouts, cashew nut, and mung bean are considered rich sources of plant protein with high levels of branched-chain amino acids. Furthermore, they contain beneficial phytochemicals such as antioxidants and anti-inflammatory agents. Additionally, there are reports suggesting that an adequate consumption of amino acids can reduce nerve cell damage, delay the onset of memory impairment, and improve sleep quality. In this study, protein isolates were prepared from the leaves of mulberry, Azolla spp., sunflower sprouts, cashew nut, and mung bean. The amino acid profile, dietary fiber content, phenolic content, and flavonoid content were evaluated. Pharmacological properties, such as antioxidant, anticholinesterase, monoamine oxidase, and γ-aminobutyric acid transaminase (GABA-T) activities, were also assessed. This study found that concentrated protein from mung beans has a higher quantity of essential amino acids (52,161 mg/100 g protein) compared to concentrated protein from sunflower sprouts (47,386 mg/100 g protein), Azolla spp. (42,097 mg/100 g protein), cashew nut (26,710 mg/100 g protein), and mulberry leaves (8931 mg/100 g protein). The dietary fiber content ranged from 0.90% to 3.24%, while the phenolic content and flavonoid content ranged from 0.25 to 2.29 mg/g and 0.01 to 2.01 mg/g of sample, respectively. Sunflower sprout protein isolates exhibited the highest levels of dietary fiber (3.24%), phenolic content (2.292 ± 0.082 mg of GAE/g), and flavonoids (2.014 mg quercetin/g of sample). The biological efficacy evaluation found that concentrated protein extract from sunflower sprouts has the highest antioxidant activity; the percentages of inhibition of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical were 20.503 ± 0.288% and 18.496 ± 0.105%, respectively. Five plant-based proteins exhibited a potent inhibition of acetylcholinesterase (AChE) enzyme activity, monoamine oxidase (MAO) inhibition, and GABA-T ranging from 3.42% to 24.62%, 6.14% to 20.16%, and 2.03% to 21.99%, respectively. These findings suggest that these plant protein extracts can be used as natural resources for developing food supplements with neuroprotective activity.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38998943/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "Molecules",
            "authors": [
                {
                    "author_id": 359715,
                    "given_name": "Pontapan",
                    "family_name": "Polyiam",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359716,
                    "given_name": "Wipawee",
                    "family_name": "Thukhammee",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:25:48.605664Z",
            "article_subject_relevances": [],
            "doi": "10.3390/molecules29132990",
            "access": "open",
            "takeaways": "The leaves of mulberry, Azolla spp., sunflower sprouts, cashew nut, and mung bean are rich sources of plant protein with high levels of branched-chain amino acids and phytochemicals. There are reports that an adequate consumption of amino acids can reduce nerve cell damage, delay onset of memory impairment, and improve sleep quality.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285825,
            "title": "Assessing the Effects of Thiazole-Carboxamide Derivatives on the Biophysical Properties of AMPA Receptor Complexes as a Potential Neuroprotective Agent",
            "summary": "<jats:p>An optimal balance between excitatory and inhibitory transmission in the central nervous system provides essential neurotransmission for good functioning of the neurons. In the neurology field, a disturbed balance can lead to neurological diseases like epilepsy, Alzheimer’s, and Autism. One of the critical agents mediating excitatory neurotransmission is α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors, which are concerned with synaptic plasticity, memory, and learning. An imbalance in neurotransmission finally results in excitotoxicity and neurological pathologies that should be corrected through specific compounds. Hence, the current study will prove to be an evaluation of new thiazole-carboxamide derivatives concerning AMPAR-modulating activity and extended medicinal potential. In the current project, five previously synthesized thiazole-carboxamide derivatives, i.e., TC-1 to TC-5, were used to interact with the AMPARs expressed in HEK293T cells, which overexpress different subunits of the AMPAR. Patch-clamp analysis was carried out while the effect of the drugs on AMPAR-mediated currents was followed with a particular emphasis on the kinetics of inhibition, desensitization, and deactivation. All tested TC compounds, at all subunits, showed potent inhibition of AMPAR-mediated currents, with TC-2 being the most powerful for all subunits. These compounds shifted the receptor kinetics efficiently, mainly enhancing the deactivation rates, and hence acted as a surrogate for their neuroprotective potentials. Additionally, recently published structure–activity relationship studies identified particular substituent groups as necessary for improving the pharmacologic profiles of these compounds. In this regard, thiazole-carboxamide derivatives, particularly those classified as TC-2, have become essential negative allosteric modulators of AMPAR function and potential therapeutics in neurological disturbances underlain by the dysregulation of excitatory neurotransmission. Given their therapeutic effectiveness and safety profiles, these in vivo studies need to be further validated, although computational modeling can be further developed for drug design and selectivity. This will open possibilities for new drug-like AMPAR negative allosteric modulators with applications at the clinical level toward neurology.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38999182/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "Molecules",
            "authors": [
                {
                    "author_id": 359710,
                    "given_name": "Mohammad",
                    "family_name": "Qneibi",
                    "ORCID": "http://orcid.org/0000-0002-0702-7834",
                    "country": null
                },
                {
                    "author_id": 359711,
                    "given_name": "Mohammed",
                    "family_name": "Hawash",
                    "ORCID": "http://orcid.org/0000-0001-5640-9700",
                    "country": null
                },
                {
                    "author_id": 359712,
                    "given_name": "Sosana",
                    "family_name": "Bdir",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359713,
                    "given_name": "Mohammad",
                    "family_name": "Bdair",
                    "ORCID": "http://orcid.org/0000-0002-8968-7034",
                    "country": null
                },
                {
                    "author_id": 359714,
                    "given_name": "Samia Ammar",
                    "family_name": "Aldwaik",
                    "ORCID": "http://orcid.org/0009-0005-0866-7787",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:25:47.183445Z",
            "article_subject_relevances": [],
            "doi": "10.3390/molecules29133232",
            "access": "open",
            "takeaways": "An optimal balance between excitatory and inhibitory transmission in the central nervous system provides essential neurotransmission for good functioning of the neurons. In the neurology field, a disturbed balance can lead to neurological diseases like epilepsy, Alzheimer’s, and Autism. Five previously synthesized thiazole-carboxamide derivatives were used to interact with AMPARs expressed in HEK293T cells. All tested TC compounds showed potent inhibition of AMPAR-mediated currents. TC-2",
            "team_categories": [],
            "ml_predictions": []
        }
    ]
}