List all articles in the database by earliest discovery_date

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    "count": 26469,
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    "results": [
        {
            "article_id": 616,
            "title": "Bayesian approach for predicting responses to therapy from high-dimensional time-course gene expression profiles",
            "summary": "Background: Historical and updated information provided by time-course data collected during an entire treatment period proves to be more useful than information provided by single-point data. Accurate predictions made using time-course data on multiple biomarkers that indicate a patient’s response to therapy contribute positively to the decision-making process associated with designing effective treatment programs for various diseases. Therefore, the development of prediction methods incorporating time-course data on multiple markers is necessary.ResultsWe proposed new methods that may be used for prediction and gene selection via time-course gene expression profiles. Our prediction method consolidated multiple probabilities calculated using gene expression profiles collected over a series of time points to predict therapy response. Using two data sets collected from patients with hepatitis C virus (HCV) infection and multiple sclerosis (MS), we performed numerical experiments that predicted response to therapy and evaluated their accuracies. Our methods were more accurate than conventional methods and successfully selected genes, the functions of which were associated with the pathology of HCV infection and MS.ConclusionsThe proposed method accurately predicted response to therapy using data at multiple time points. It showed higher accuracies at early time points compared to those of conventional methods. Furthermore, this method successfully selected genes that were directly associated with diseases.",
            "link": "https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-021-04052-4",
            "published_date": "2021-03-18T00:00:00Z",
            "sources": [
                "BioMedCentral"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
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            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "BMC Bioinformatics",
            "authors": [
                {
                    "author_id": 268301,
                    "given_name": "Arika",
                    "family_name": "Fukushima",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 213458,
                    "given_name": "Masahiro",
                    "family_name": "Sugimoto",
                    "ORCID": "http://orcid.org/0000-0003-3316-2543",
                    "country": "JP"
                },
                {
                    "author_id": 268302,
                    "given_name": "Satoru",
                    "family_name": "Hiwa",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 170289,
                    "given_name": "Tomoyuki",
                    "family_name": "Hiroyasu",
                    "ORCID": "http://orcid.org/0000-0003-0730-7905",
                    "country": "JP"
                }
            ],
            "discovery_date": "2021-03-19T02:40:51Z",
            "article_subject_relevances": [],
            "doi": "10.1186/s12859-021-04052-4",
            "access": "open",
            "takeaways": " Time-course data on multiple biomarkers that indicate a patient’s response to therapy contribute positively to the decision-making process associated with designing effective treatment programs for various diseases .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:51:50.597456Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 618,
            "title": "Effect of ‘hand and foot acupuncture with twelve needles’ on hemiplegia patients with ‘qi deficiency and blood stasis’ syndrome in the convalescent stage of Ischaemic stroke: study protocol for a randomised controlled trial",
            "summary": "Background: Hemiplegia is a common sequela after stroke, and acupuncture is one of the most common physical therapies used to treat hemiplegia during the recovery stage after ischaemic stroke. ‘Hand and foot acupuncture with twelve needles’ is an acupuncture treatment performed after stroke. The principal objective of this study is to assess the efficacy and safety of ‘hand and foot acupuncture with twelve needles’ for hemiplegia in the convalescent stage of ischaemic stroke.MethodsThis is the protocol for a randomised, controlled clinical trial with two groups: a ‘hand and foot acupuncture with twelve needles’ group and a routine acupuncture group. A total of 208 participants will be randomly assigned to two different groups in a 1:1 ratio and will undergo conventional rehabilitation. Limb function will be evaluated by the simplified Fugl-Meyer assessment scale, Barthel Index, modified Ashworth scale and National Institute of Health stroke scale. The participants will be evaluated at baseline (on the day of enrolment) and followed up at 2 weeks, 1 month, 2 months and 3 months after enrolment.DiscussionThe results of this study will provide evidence on the effectiveness of ‘hand and foot acupuncture with twelve needles’ in the treatment of limb dysfunction that can be used for future evaluations.Trial registrationChictr.org.cnChiCTR1900021774. Registered on 8 March 2019",
            "link": "https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05128-5",
            "published_date": "2021-03-18T00:00:00Z",
            "sources": [
                "BioMedCentral"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Trials",
            "authors": [
                {
                    "author_id": 283674,
                    "given_name": "Da-Wei",
                    "family_name": "Zhang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 283675,
                    "given_name": "Qing",
                    "family_name": "Wei",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 184099,
                    "given_name": "Hu",
                    "family_name": "Zhang",
                    "ORCID": "http://orcid.org/0000-0002-3183-6690",
                    "country": null
                },
                {
                    "author_id": 283668,
                    "given_name": "Wei-Hao",
                    "family_name": "Fang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 283670,
                    "given_name": "Gui-Ling",
                    "family_name": "Wang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 167182,
                    "given_name": "Qiang",
                    "family_name": "Liu",
                    "ORCID": "http://orcid.org/0000-0002-6621-0591",
                    "country": null
                },
                {
                    "author_id": 261530,
                    "given_name": "Xiao",
                    "family_name": "Ding",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 283671,
                    "given_name": "Zhen-Yao",
                    "family_name": "Wang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 283672,
                    "given_name": "Xin-Wei",
                    "family_name": "Wang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 283673,
                    "given_name": "Xiao-Wei",
                    "family_name": "Yang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 327902,
                    "given_name": "Yang",
                    "family_name": "Yang",
                    "ORCID": "http://orcid.org/0000-0002-0273-9242",
                    "country": null
                }
            ],
            "discovery_date": "2021-03-19T02:40:51Z",
            "article_subject_relevances": [],
            "doi": "10.1186/s13063-021-05128-5",
            "access": "open",
            "takeaways": " ‘Hand and foot acupuncture with twelve needles’ is an acupuncture treatment performed after stroke . Hemiplegia is a common sequela after stroke and acupuncture is one of the most common physical therapies used to treat it .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:53:10.280754Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 617,
            "title": "Repair abilities of mouse autologous adipose-derived stem cells and ShakeGel™3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation",
            "summary": "Background: The objective was to explore the therapeutic effect of autologous adipose-derived stem cells (ADSCs) combined with ShakeGel™3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine adhesions (IUA).MethodsAutologous ADSCs were isolated and then merged with ShakeGel™3D. The IUA model was established by mechanical injury. The third generation of autologous ADSCs was injected directly into the uterus in combination with ShakeGel™3D. After 7 days of treatment, endometrial morphology, number of endometrial glands, endometrial fibrosis area, and fibrosis biomarker analysis by RT-PCR and IHC were examined. BMP7 and phosphorylation of Smad5 were also detected, and the recovery of infertility function in treated mice was evaluated.ResultsFluorescence-activated cell sorting (FACS) showed that autologous ADSCs expressed CD105 (99.1%), CD29 (99.6%), and CD73 (98.9%). Autologous ADSCs could still maintain a good growth state in ShakeGel™3D. Histological examination revealed that the number of endometrial glands increased significantly, and the area of fibrosis decreased. At the same time, the expression of BMP7 and Smad5 in the ADSCs + Gel group was significantly upregulated, and the final reproductive function of this group was partly recovered.ConclusionsAutologous ADSCs can be used in combination with ShakeGel™3D to maintain functionality and create a viable three-dimensional growth environment. The combined transplantation of autologous ADSCs and ShakeGel™3D promotes the recovery of damaged endometrial tissue by increasing BMP7-Smad5 signal transduction, resulting in endometrium thickening, increased number of glands, and decreased fibrosis, leading to restoration of partial fertility.",
            "link": "https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02258-0",
            "published_date": "2021-03-18T00:00:00Z",
            "sources": [
                "BioMedCentral"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Stem Cell Research & Therapy",
            "authors": [
                {
                    "author_id": 209210,
                    "given_name": "Yun-xia",
                    "family_name": "Zhao",
                    "ORCID": "http://orcid.org/0000-0002-0195-5031",
                    "country": null
                },
                {
                    "author_id": 300117,
                    "given_name": "Shao-rong",
                    "family_name": "Chen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 222400,
                    "given_name": "Qiao-yi",
                    "family_name": "Huang",
                    "ORCID": "http://orcid.org/0000-0002-7254-3712",
                    "country": null
                },
                {
                    "author_id": 300118,
                    "given_name": "Wei-can",
                    "family_name": "Chen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 300119,
                    "given_name": "Tian",
                    "family_name": "Xia",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 300120,
                    "given_name": "Yan-chuan",
                    "family_name": "Shi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 300121,
                    "given_name": "Hong-zhi",
                    "family_name": "Gao",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 300122,
                    "given_name": "Qi-yang",
                    "family_name": "Shi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 300123,
                    "given_name": "Shu",
                    "family_name": "Lin",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2021-03-19T02:40:51Z",
            "article_subject_relevances": [],
            "doi": "10.1186/s13287-021-02258-0",
            "access": "open",
            "takeaways": " Autologous adipose-derived stem cells (ADSCs) combined with ShakeGel™3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine adhesions (IUA)",
            "team_categories": [
                {
                    "id": 9,
                    "category_name": "Stem Cells",
                    "category_description": "Autologous Hematopoietic Stem Cell Transplantation (aHSCT) and other stem cell therapies",
                    "category_slug": "stem-cells",
                    "category_terms": [
                        "stem cells",
                        "Autologous hematopoietic stem cell",
                        "ahsct"
                    ]
                }
            ],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:56:19.631101Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 610,
            "title": "CORNEAL SUBBASAL NERVE PLEXUS EVALUATION BY IN VIVO CONFOCAL MICROSCOPY IN MULTIPLE SCLEROSIS: A POTENTIAL NEW BIOMARKER",
            "summary": "<div><p>Curr Eye Res. 2021 Mar 18. doi: 10.1080/02713683.2021.1904509. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><b>Purpose/Aim</b>: Our study aims to evaluate corneal subbasal nerve plexus morphology by <i>in vivo</i> corneal confocal microscopy (CCM) in Multiple Sclerosis (MS) patients, and to explore their potential ability to distinguish between MS patients and healthy subjects.<b>Materials and Methods</b>: Cross-sectional study, including sixty MS patients and twenty-two healthy subjects. Expanded Disability Status Scale (EDSS) was used to assess neurological disability. All participants underwent full ophthalmology evaluation, CCM and optical coherence tomography (OCT). Corneal nerve fibre density (CNFD), branch density (CNBD), fibre length (CNFL) and fibre tortuosity (CNFT) were analysed. Generalized additive regression models were used to analyse the data.<b>Results</b>: Compared to controls, MS patients had lower CNFD, CNBD and CNFL (p&lt;0.001) and higher CNFT (p=0.002). The area under the ROC curve to distinguish MS patients from healthy controls with CNFD and CNBD was 0.84 (95%CI: 0.75 to 0.93; 95%CI: 0.75 to 0.92, respectively). A nonlinear association between EDSS and CNFD was found, with an initial density increase followed by a significant decrease until more severe disability status. EDSS was associated with CNFL and CNBD, with values being significantly lower for patients with an EDSS&gt;2.5 (-2.06 mm/mm2; 95%CI: -3.84 to -0.28; p=0.027 and -8.70 branches/mm2; 95%CI: -14.69 to -2.71; p=0.006, respectively). An optic neuritis (ON) history did not influence CCM parameters.<b>Conclusions</b>: Our results confirm CCM parameters' potential to differentiate MS patients from healthy subjects, not being influenced by a previous ON history. A significant relationship between patient's disability and corneal nerves morphology was also found.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33734930/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318194521&amp;v=2.14.3\">33734930</a> | DOI:<a href=\"https://doi.org/10.1080/02713683.2021.1904509\">10.1080/02713683.2021.1904509</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33734930/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-01-10T00:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Informa UK Limited",
            "container_title": "Current Eye Research",
            "authors": [
                {
                    "author_id": 193848,
                    "given_name": "Diogo",
                    "family_name": "Fernandes",
                    "ORCID": "http://orcid.org/0000-0002-5972-4068",
                    "country": null
                },
                {
                    "author_id": 269612,
                    "given_name": "Maria",
                    "family_name": "Luís",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269613,
                    "given_name": "Joana",
                    "family_name": "Cardigos",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269614,
                    "given_name": "Catarina",
                    "family_name": "Xavier",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269615,
                    "given_name": "Marta",
                    "family_name": "Alves",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269616,
                    "given_name": "Ana Luísa",
                    "family_name": "Papoila",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269617,
                    "given_name": "João Paulo",
                    "family_name": "Cunha",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 269618,
                    "given_name": "Joana Tavares",
                    "family_name": "Ferreira",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2021-03-18T23:45:23Z",
            "article_subject_relevances": [],
            "doi": "10.1080/02713683.2021.1904509",
            "access": "restricted",
            "takeaways": " Corneal nerve fibre density (CNFD), branch density (CNBD), fibre length (CNFL) and fibre tortuosity (CNFT) were analysed . MS patients had lower CNFD, CNBD and CNFL (p<0.001) and higher CNFT (p=0.002) An optic neuritis history did not influence CCM parameters .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:52:33.455233Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 609,
            "title": "Secondary progressive multiple sclerosis: a systematic review of costs and health state utilities",
            "summary": "<div><p>Curr Med Res Opin. 2021 Mar 18:1. doi: 10.1080/03007995.2021.1904860. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><b><i>Objective:</i></b> To identify evidence in the literature presenting the economic and humanistic (based on health state utility values [HSUVs]) burden of multiple sclerosis (MS) and report the incremental burden of secondary progressive MS (SPMS) compared with relapsing-remitting MS (RRMS).<b><i>Methods:</i></b> Electronic databases (Embase®, MEDLINE<sup>®</sup>, MEDLINE<sup>®</sup> In-Process, Cochrane Library) and other relevant repositories were systematically searched from the date of inception until November 2019 for evidence on the economic burden of MS, or HSUVs in patients with MS. Data were extracted from studies investigating cost data or HSUVs for patients with SPMS compared with RRMS.<b><i>Results:</i></b> In total, 25 studies were identified that reported data on the economic and HSUV burden of SPMS versus RRMS: 18 studies reported cost data and nine presented HSUVs. Overall, costs associated with SPMS were consistently higher than those for RRMS. Major cost drivers appeared to shift following transition from RRMS to SPMS, with higher direct medical costs associated with RRMS than with SPMS, while the opposite was true for direct non-medical costs and indirect costs. In all studies presenting HSUVs specifically in patients with SPMS, the disease burden was greater (indicated by lower HSUV scores or a negative regression coefficient vs RRMS) for patients with SPMS than for those with RRMS. Fatigue and psychological stress (including depression) were identified as key drivers of this reduced health-related quality of life (HRQoL).<b><i>Conclusions:</i></b> Our findings indicate that SPMS is associated with higher costs and more substantial HRQoL decrements than RRMS. These results highlight the substantial unmet need for effective treatments that can slow disease progression in patients with SPMS, which, in turn, would reduce the rate of HRQoL deterioration and increasing healthcare costs.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33733976/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318194521&amp;v=2.14.3\">33733976</a> | DOI:<a href=\"https://doi.org/10.1080/03007995.2021.1904860\">10.1080/03007995.2021.1904860</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33733976/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-01-06T00:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Informa UK Limited",
            "container_title": "Current Medical Research and Opinion",
            "authors": [
                {
                    "author_id": 148223,
                    "given_name": "Jeremy",
                    "family_name": "Chataway",
                    "ORCID": "http://orcid.org/0000-0001-7286-6901",
                    "country": null
                },
                {
                    "author_id": 242465,
                    "given_name": "Niamh",
                    "family_name": "Murphy",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 148225,
                    "given_name": "Vivek",
                    "family_name": "Khurana",
                    "ORCID": "http://orcid.org/0000-0001-6571-0263",
                    "country": null
                },
                {
                    "author_id": 242467,
                    "given_name": "Helen",
                    "family_name": "Schofield",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 242469,
                    "given_name": "John",
                    "family_name": "Findlay",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 148228,
                    "given_name": "Nicholas",
                    "family_name": "Adlard",
                    "ORCID": "http://orcid.org/0000-0001-6912-1685",
                    "country": null
                }
            ],
            "discovery_date": "2021-03-18T23:45:23Z",
            "article_subject_relevances": [],
            "doi": "10.1080/03007995.2021.1904860",
            "access": "open",
            "takeaways": " Costs associated with secondary progressive MS (SPMS) were consistently higher than those for RRMS . Fatigue and psychological stress (including depression) were identified as key drivers of this reduced health-related quality of life (HRQoL)",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:56:40.550208Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 611,
            "title": "Central neuropathic pain in multiple sclerosis is associated with impaired innocuous thermal pathways and neuronal hyperexcitability",
            "summary": "<div><p>Pain Med. 2021 Mar 18:pnab103. doi: 10.1093/pm/pnab103. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">OBJECTIVE: About a third of patients with multiple sclerosis (MS) suffer from chronic and excruciating central neuropathic pain (CNP). The mechanism underlying CNP in MS is not clear, since previous studies are scarce and their results are inconsistent. Our aim was to determine whether CNP in MS is associated with impairment of the spinothalamic-thalamocortical pathways (STTCs) and/or increased excitability of the pain system.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">DESIGN: Cross sectional study.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">SETTING: General hospital.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">SUBJECTS: 47 MS patients with CNP, 42 MS patients without CNP, and 32 healthy controls.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">METHODS: Sensory testing included the measurement of temperature, pain, and touch thresholds and the thermal grill illusion (TGI) for evaluating STTCs function, and hyperpathia and allodynia as indicators of hyperexcitability. CNP was characterized using interviews and questionnaires.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">RESULTS: The CNP group had higher cold and warm thresholds (p &lt; 0.01), as well as higher TGI perception thresholds (p &lt; 0.05), especially in painful body regions compared to controls, whereas touch and pain thresholds values were normal. The CNP group also had a significantly greater prevalence of hyperpathia and allodynia. Regression analysis revealed that whereas presence of CNP was associated with a higher cold threshold, CNP intensity, and the number of painful body regions were associated with allodynia and hyperpathia, respectively.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">CONCLUSIONS: CNP in MS is characterized by a specific impairment of STTC function; the innocuous thermal pathways, and by pain hyperexcitability. Whereas CNP presence is associated with STTC impairment, its severity and extent are associated with pain hyperexcitability. Interventions that reduce excitability level may therefore mitigate CNP severity.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33734398/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318194521&amp;v=2.14.3\">33734398</a> | DOI:<a href=\"https://doi.org/10.1093/pm/pnab103\">10.1093/pm/pnab103</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33734398/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-10-07T23:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Oxford University Press (OUP)",
            "container_title": "Pain Medicine",
            "authors": [
                {
                    "author_id": 244962,
                    "given_name": "Michal",
                    "family_name": "Rivel",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 154701,
                    "given_name": "Anat",
                    "family_name": "Achiron",
                    "ORCID": "http://orcid.org/0000-0002-2020-3126",
                    "country": null
                },
                {
                    "author_id": 154699,
                    "given_name": "Mark",
                    "family_name": "Dolev",
                    "ORCID": "http://orcid.org/0000-0001-8181-9226",
                    "country": null
                },
                {
                    "author_id": 244967,
                    "given_name": "Yael",
                    "family_name": "Stern",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 244968,
                    "given_name": "Gabi",
                    "family_name": "Zeilig",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 186699,
                    "given_name": "Ruth",
                    "family_name": "Defrin",
                    "ORCID": "http://orcid.org/0000-0002-2719-4007",
                    "country": null
                }
            ],
            "discovery_date": "2021-03-18T23:45:23Z",
            "article_subject_relevances": [],
            "doi": "10.1093/pm/pnab103",
            "access": "restricted",
            "takeaways": " About a third of patients with multiple sclerosis suffer from chronic and excruciating central neuropathic pain (CNP) The mechanism underlying CNP in MS is not clear, since previous studies are scarce and their results are inconsistent .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:52:04.439870Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 607,
            "title": "Retinal layer thinning predicts treatment failure in relapsing multiple sclerosis",
            "summary": "<div><p>Eur J Neurol. 2021 Mar 18. doi: 10.1111/ene.14829. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">BACKGROUND: Peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell plus inner plexiform layer (GCIPL) thinning are markers of neuroaxonal degeneration in multiple sclerosis (MS), which is reduced by disease-modifying treatment (DMT). We aimed to investigate the potential of pRNFL and GCIPL thinning for prediction of DMT failure in relapsing MS (RMS).</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">METHODS: In this 4-year prospective observational study on 113 RMS patients, pRNFL and GCIPL were measured at DMT initiation and after 12 (M12) and 24 months (M24). Treatment failure was defined as 6-month-confirmed EDSS progression and/or Symbol Digit Modalities Test (SDMT) worsening. Optimal cut-off values for predicting treatment failure were determined by receiver-operating-characteristic-(ROC)-analyses, and hazard ratios (HR) by multivariable Cox regression adjusting for age, sex, disease duration, EDSS/SDMT and DMT class.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">RESULTS: Thinning of GCIPL &gt;0.5μm/year at M24 showed superior value for treatment failure prediction (HR 4.5; 95% confidence interval [CI]: 1.8 - 7.6; p&lt;0.001; specificity 91%, sensitivity 81%) followed by GCIPL &gt;0.5μm at M12 (OR 3.9; 95% CI: 1.4 - 6.9; p&lt;0.001; specificity 85%, sensitivity 78%), and pRNFL ≥2μm/year at M24 (OR 3.7; 95% CI: 1.1 - 6.5; p=0.023; specificity 84%, sensitivity 69%), while pRNFL at M12 was not predictive.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">CONCLUSIONS: GCIPL - and to a lesser degree pRNFL - thinning predicts disability progression after DMT initiation and may be a useful and accessible biomarker of treatment failure in RMS.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33735479/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318194521&amp;v=2.14.3\">33735479</a> | DOI:<a href=\"https://doi.org/10.1111/ene.14829\">10.1111/ene.14829</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33735479/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-01-06T00:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Wiley",
            "container_title": "European Journal of Neurology",
            "authors": [
                {
                    "author_id": 147832,
                    "given_name": "Gabriel",
                    "family_name": "Bsteh",
                    "ORCID": "http://orcid.org/0000-0002-0825-0851",
                    "country": null
                },
                {
                    "author_id": 147833,
                    "given_name": "Harald",
                    "family_name": "Hegen",
                    "ORCID": "http://orcid.org/0000-0002-2833-6337",
                    "country": null
                },
                {
                    "author_id": 158186,
                    "given_name": "Patrick",
                    "family_name": "Altmann",
                    "ORCID": "http://orcid.org/0000-0002-2983-3693",
                    "country": null
                },
                {
                    "author_id": 152577,
                    "given_name": "Michael",
                    "family_name": "Auer",
                    "ORCID": "http://orcid.org/0000-0002-5117-4225",
                    "country": null
                },
                {
                    "author_id": 164755,
                    "given_name": "Klaus",
                    "family_name": "Berek",
                    "ORCID": "http://orcid.org/0000-0003-2755-2043",
                    "country": null
                },
                {
                    "author_id": 153251,
                    "given_name": "Franziska",
                    "family_name": "Di Pauli",
                    "ORCID": "http://orcid.org/0000-0001-6183-2394",
                    "country": null
                },
                {
                    "author_id": 163863,
                    "given_name": "Fritz",
                    "family_name": "Leutmezer",
                    "ORCID": "http://orcid.org/0000-0001-5665-8635",
                    "country": null
                },
                {
                    "author_id": 147838,
                    "given_name": "Paulus",
                    "family_name": "Rommer",
                    "ORCID": "http://orcid.org/0000-0001-5209-6647",
                    "country": null
                },
                {
                    "author_id": 179630,
                    "given_name": "Sebastian",
                    "family_name": "Wurth",
                    "ORCID": "http://orcid.org/0000-0001-7122-0842",
                    "country": null
                },
                {
                    "author_id": 224621,
                    "given_name": "Anne",
                    "family_name": "Zinganell",
                    "ORCID": "http://orcid.org/0000-0002-4664-9310",
                    "country": null
                },
                {
                    "author_id": 189104,
                    "given_name": "Tobias",
                    "family_name": "Zrzavy",
                    "ORCID": "http://orcid.org/0000-0001-8909-1591",
                    "country": null
                },
                {
                    "author_id": 147844,
                    "given_name": "Florian",
                    "family_name": "Deisenhammer",
                    "ORCID": "http://orcid.org/0000-0003-4541-8841",
                    "country": null
                },
                {
                    "author_id": 163862,
                    "given_name": "Thomas",
                    "family_name": "Berger",
                    "ORCID": "http://orcid.org/0000-0001-5626-1144",
                    "country": null
                }
            ],
            "discovery_date": "2021-03-18T23:45:23Z",
            "article_subject_relevances": [],
            "doi": "10.1111/ene.14829",
            "access": "open",
            "takeaways": " Peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell plus inner plexiform layer (GCIPL) thinning are markers of neuroaxonal degeneration in multiple sclerosis (MS) Thinning of GCIPL >0.5μm/year at M24 showed superior value for treatment failure prediction .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:56:23.132691Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 608,
            "title": "Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis",
            "summary": "<div><p>PLoS One. 2021 Mar 18;16(3):e0247901. doi: 10.1371/journal.pone.0247901. eCollection 2021.</p><p><b>ABSTRACT</b></p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Vision impairment due to optic neuritis (ON) is one of the major clinical presentations in Multiple Sclerosis (MS) and is characterized by inflammation and degeneration of the optic nerve and retina. Currently available treatments are only partially effective and have a limited impact on the neuroinflammatory pathology of the disease. A recent study from our laboratory highlighted the beneficial effect of arginase 2 (A2) deletion in suppressing retinal neurodegeneration and inflammation in an experimental model of MS. Utilizing the same model, the present study investigated the impact of A2 deficiency on MS-induced optic neuritis. Experimental autoimmune encephalomyelitis (EAE) was induced in wild-type (WT) and A2 knockout (A2-/-) mice. EAE-induced cellular infiltration, as well as activation of microglia and macrophages, were reduced in A2-/- optic nerves. Axonal degeneration and demyelination seen in EAE optic nerves were observed to be reduced with A2 deletion. Further, the lack of A2 significantly ameliorated astrogliosis induced by EAE. In conclusion, our findings demonstrate a critical involvement of arginase 2 in mediating neuroinflammation in optic neuritis and suggest the potential of A2 blockade as a targeted therapy for MS-induced optic neuritis.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33735314/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318194521&amp;v=2.14.3\">33735314</a> | DOI:<a href=\"https://doi.org/10.1371/journal.pone.0247901\">10.1371/journal.pone.0247901</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33735314/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-03-18T00:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Public Library of Science (PLoS)",
            "container_title": "PLOS ONE",
            "authors": [
                {
                    "author_id": 227528,
                    "given_name": "Amritha A.",
                    "family_name": "Candadai",
                    "ORCID": "http://orcid.org/0000-0003-3661-8200",
                    "country": null
                },
                {
                    "author_id": 211987,
                    "given_name": "Fang",
                    "family_name": "Liu",
                    "ORCID": "http://orcid.org/0000-0001-5463-6395",
                    "country": null
                },
                {
                    "author_id": 245029,
                    "given_name": "Abdelrahman Y.",
                    "family_name": "Fouda",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 245030,
                    "given_name": "Moaddey",
                    "family_name": "Alfarhan",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 245031,
                    "given_name": "Chithra D.",
                    "family_name": "Palani",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 245032,
                    "given_name": "Zhimin",
                    "family_name": "Xu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 245033,
                    "given_name": "Ruth B.",
                    "family_name": "Caldwell",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 227534,
                    "given_name": "S. Priya",
                    "family_name": "Narayanan",
                    "ORCID": "http://orcid.org/0000-0002-8842-622X",
                    "country": null
                }
            ],
            "discovery_date": "2021-03-18T23:45:23Z",
            "article_subject_relevances": [],
            "doi": "10.1371/journal.pone.0247901",
            "access": "open",
            "takeaways": " Arginase 2 (A2) deletion suppressed retinal neurodegeneration and inflammation in an experimental model of MS . Axonal degeneration and demyelination seen in EAE optic nerves were observed to be reduced with A2 deletion . The lack of A2 significantly ameliorated astrogliosis induced by EAE .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:52:47.077548Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 612,
            "title": "Age of hypertension onset in multiple sclerosis patients",
            "summary": "<div><p>Mult Scler. 2021 Mar 18:13524585211003016. doi: 10.1177/13524585211003016. Online ahead of print.</p><p><b>ABSTRACT</b></p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">BACKGROUND/OBJECTIVE: Hypertension (HTN) is common in multiple sclerosis (MS), and it is associated with poorer outcomes. We sought to characterize HTN age at onset (AAO) by MS status.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">METHODS/RESULTS: There were 130,050 incident HTN patients, among whom there were 892 MS patients. We conducted multivariable linear regression adjusting for patient attributes. Sex- and race-stratified models were conducted. HTN AAO did not differ in patients with and without MS (<i>p</i> = 0.17). Similar null associations were observed in the sex- and race-specific analyses.</p><p xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:p1=\"http://pubmed.gov/pub-one\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">CONCLUSION: While there are complex relationships between HTN and MS, there are no differences in HTN AAO by MS status.</p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33733922/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318194521&amp;v=2.14.3\">33733922</a> | DOI:<a href=\"https://doi.org/10.1177/13524585211003016\">10.1177/13524585211003016</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33733922/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-01-11T00:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "SAGE Publications",
            "container_title": "Multiple Sclerosis Journal",
            "authors": [
                {
                    "author_id": 157644,
                    "given_name": "Farren BS",
                    "family_name": "Briggs",
                    "ORCID": "http://orcid.org/0000-0003-0903-1359",
                    "country": null
                },
                {
                    "author_id": 292501,
                    "given_name": "Diane",
                    "family_name": "Krill",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 292502,
                    "given_name": "Eddie",
                    "family_name": "Hill",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 172707,
                    "given_name": "Devon S.",
                    "family_name": "Conway",
                    "ORCID": "http://orcid.org/0000-0001-5359-6686",
                    "country": null
                }
            ],
            "discovery_date": "2021-03-18T23:45:23Z",
            "article_subject_relevances": [],
            "doi": "10.1177/13524585211003016",
            "access": "restricted",
            "takeaways": " Hypertension (HTN) is common in multiple sclerosis and associated with poorer outcomes . We sought to characterize HTN age at onset (AAO) by MS status . HTN AAO did not differ in patients with and without MS .",
            "team_categories": [],
            "ml_predictions": [
                {
                    "gnb": null,
                    "lr": null,
                    "lsvc": null,
                    "mnb": null,
                    "created_date": "2024-05-25T01:51:13.241966Z",
                    "subject": 1
                }
            ]
        },
        {
            "article_id": 605,
            "title": "Editorial: &quot;Inside-Out&quot; vs &quot;Outside-In&quot; Paradigms in Multiple Sclerosis Etiopathogenesis",
            "summary": "<div><p>Front Cell Neurosci. 2021 Mar 1;15:666529. doi: 10.3389/fncel.2021.666529. eCollection 2021.</p><p><b>NO ABSTRACT</b></p><p>PMID:<a href=\"https://pubmed.ncbi.nlm.nih.gov/33732113/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318140555&amp;v=2.14.3\">33732113</a> | PMC:<a href=\"https://www.ncbi.nlm.nih.gov/pmc/PMC7957074/?utm_source=Other&amp;utm_medium=rss&amp;utm_campaign=pubmed-2&amp;utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&amp;fc=20210216052009&amp;ff=20210318140555&amp;v=2.14.3\">PMC7957074</a> | DOI:<a href=\"https://doi.org/10.3389/fncel.2021.666529\">10.3389/fncel.2021.666529</a></p></div>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/33732113/#x3D;Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=10guX6I3SqrbUeeLKSTD6FCRM44ewnrN2MKKTQLLPMHB4xNsZU&fc&#x",
            "published_date": "2021-03-01T00:00:00Z",
            "sources": [
                "PubMed"
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            "publisher": "Frontiers Media SA",
            "container_title": "Frontiers in Cellular Neuroscience",
            "authors": [
                {
                    "author_id": 199657,
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            "article_subject_relevances": [],
            "doi": "10.3389/fncel.2021.666529",
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