List all articles in the database by earliest discovery_date

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{
    "count": 26469,
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        {
            "article_id": 285847,
            "title": "Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution",
            "summary": "Air pollution (AP) exposures have been associated with numerous neurodevelopmental and psychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia, all male-biased disorders with onsets from early life to late adolescence/early adulthood. While prior experimental studies have focused on effects of AP exposures during early brain development, brain development actually extends well into early adulthood. The current study in mice sought to...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002649/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
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                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
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            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "NeuroToxicology",
            "authors": [
                {
                    "author_id": 359795,
                    "given_name": "D.A.",
                    "family_name": "Cory-Slechta",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359796,
                    "given_name": "E.",
                    "family_name": "Marvin",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359797,
                    "given_name": "K.",
                    "family_name": "Welle",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359798,
                    "given_name": "C.",
                    "family_name": "Goeke",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359799,
                    "given_name": "D.",
                    "family_name": "Chalupa",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359800,
                    "given_name": "G.",
                    "family_name": "Oberdörster",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359801,
                    "given_name": "M.",
                    "family_name": "Sobolewski",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:25:17.324227Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.neuro.2024.07.004",
            "access": "restricted",
            "takeaways": "Air pollution has been associated with numerous neurodevelopmental and psychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia.",
            "team_categories": [
                {
                    "id": 27,
                    "category_name": "Kynurenine",
                    "category_description": "Kynurenine was added as a category based on this article: https://pubmed.ncbi.nlm.nih.gov/36004319/",
                    "category_slug": "kynurenine",
                    "category_terms": [
                        "Kynurenine"
                    ]
                }
            ],
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        {
            "article_id": 285846,
            "title": "Convergent and divergent transcriptional reprogramming of motor and sensory neurons underlying response to peripheral nerve injury",
            "summary": "CONCLUSIONS: This comprehensive analysis revealed convergent and divergent injury response genes in SNs and MNs, providing new insights into transcriptional reprogramming of sensory and motor neurons responding to axonal injury and subsequent regeneration. It also identified some novel regeneration-associated candidates that may facilitate the development of strategies for axon regeneration.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002719/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
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                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
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                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
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            "publisher": null,
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            "discovery_date": "2024-07-14T11:25:16.404998Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.jare.2024.07.008",
            "access": "restricted",
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        {
            "article_id": 285845,
            "title": "Clemastine improves emotional and social deficits in adolescent social isolation mice by reversing demyelination",
            "summary": "Adolescence is a critical period for social experience-dependent oligodendrocyte maturation and myelination. Adolescent stress predisposes to cause irreversible changes in brain structure and function with lasting effects on adulthood or beyond. However, the molecular mechanisms linking adolescent social isolation stress with emotional and social competence remain largely unknown. In our study, we found that social isolation during adolescence leads to anxiety-like behaviors, depression-like...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002803/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
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                    "modified": "2024-07-04T10:58:33.274216Z",
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                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
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            ],
            "publisher": "Elsevier BV",
            "container_title": "Pharmacology Biochemistry and Behavior",
            "authors": [
                {
                    "author_id": 359792,
                    "given_name": "Dan",
                    "family_name": "Guo",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359793,
                    "given_name": "Yuan",
                    "family_name": "Yao",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359794,
                    "given_name": "Xiumin",
                    "family_name": "Liu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 282826,
                    "given_name": "Ying",
                    "family_name": "Han",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:25:15.114968Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.pbb.2024.173824",
            "access": "restricted",
            "takeaways": "Adolescence is a critical period for social experience-dependent oligodendrocyte maturation and myelination. Adolescent stress",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285844,
            "title": "Mitochondrial regulation of adult hippocampal neurogenesis: Insights into neurological function and neurodevelopmental disorders",
            "summary": "Mitochondria are essential regulators of cellular energy metabolism and play a crucial role in the maintenance and function of neuronal cells. Studies in the last decade have highlighted the importance of mitochondrial dynamics and bioenergetics in adult neurogenesis, a process that significantly influences cognitive function and brain plasticity. In this review, we examine the mechanisms by which mitochondria regulate adult neurogenesis, focusing on the impact of mitochondrial function on the...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002810/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
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            ],
            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
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            ],
            "publisher": "Elsevier BV",
            "container_title": "Neurobiology of Disease",
            "authors": [
                {
                    "author_id": 359787,
                    "given_name": "Sara",
                    "family_name": "Bonzano",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359788,
                    "given_name": "Eleonora",
                    "family_name": "Dallorto",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359789,
                    "given_name": "Serena",
                    "family_name": "Bovetti",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359790,
                    "given_name": "Michèle",
                    "family_name": "Studer",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359791,
                    "given_name": "Silvia",
                    "family_name": "De Marchis",
                    "ORCID": null,
                    "country": null
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            ],
            "discovery_date": "2024-07-14T11:25:13.860688Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.nbd.2024.106604",
            "access": "open",
            "takeaways": "Mitochondria are essential regulators of cellular energy metabolism and play a crucial role in the maintenance and function of neuronal cells. Studies in the last decade have highlighted the",
            "team_categories": [],
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        },
        {
            "article_id": 285843,
            "title": "Increased spontaneous activity and progressive suppression of adult neurogenesis in the hippocampus of rat offspring after maternal exposure to imidacloprid",
            "summary": "Imidacloprid (IMI) is a widely used neonicotinoid insecticide that poses risks for developmental neurotoxicity in mammals. The present study investigated the effects of maternal exposure to IMI on behaviors and adult neurogenesis in the hippocampal dentate gyrus (DG) of rat offspring. Dams were exposed to IMI via diet (83, 250, or 750 ppm in diet) from gestational day 6 until day 21 post-delivery on weaning, and offspring were maintained until adulthood on postnatal day 77. In the neurogenic...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002876/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
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            ],
            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
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            ],
            "publisher": "Elsevier BV",
            "container_title": "Chemico-Biological Interactions",
            "authors": [
                {
                    "author_id": 359777,
                    "given_name": "Xinyu",
                    "family_name": "Zou",
                    "ORCID": "http://orcid.org/0000-0001-8551-9319",
                    "country": null
                },
                {
                    "author_id": 359778,
                    "given_name": "Qian",
                    "family_name": "Tang",
                    "ORCID": "http://orcid.org/0009-0001-8369-9798",
                    "country": null
                },
                {
                    "author_id": 359779,
                    "given_name": "Ryota",
                    "family_name": "Ojiro",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359780,
                    "given_name": "Shunsuke",
                    "family_name": "Ozawa",
                    "ORCID": "http://orcid.org/0000-0003-1102-5871",
                    "country": null
                },
                {
                    "author_id": 359781,
                    "given_name": "Momoka",
                    "family_name": "Shobudani",
                    "ORCID": "http://orcid.org/0009-0004-7184-4654",
                    "country": null
                },
                {
                    "author_id": 359782,
                    "given_name": "Yuri",
                    "family_name": "Sakamaki",
                    "ORCID": "http://orcid.org/0009-0009-1939-3565",
                    "country": null
                },
                {
                    "author_id": 359783,
                    "given_name": "Yuri",
                    "family_name": "Ebizuka",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359784,
                    "given_name": "Meilan",
                    "family_name": "Jin",
                    "ORCID": "http://orcid.org/0000-0003-1982-5988",
                    "country": null
                },
                {
                    "author_id": 359785,
                    "given_name": "Toshinori",
                    "family_name": "Yoshida",
                    "ORCID": "http://orcid.org/0000-0003-2476-7794",
                    "country": null
                },
                {
                    "author_id": 359786,
                    "given_name": "Makoto",
                    "family_name": "Shibutani",
                    "ORCID": "http://orcid.org/0000-0003-3417-9697",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:25:12.378688Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.cbi.2024.111145",
            "access": "open",
            "takeaways": "Imidacloprid (IMI) is a widely used neonicotinoid insecticide that poses risks for developmental neurotoxicity in mammals. The present study investigated the",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285842,
            "title": "Efficacy and safety of butylphthalide in patients with mild cognitive impairment: a multicentre, randomised, double-blind, placebo-controlled trial (EBMCI study)",
            "summary": "<jats:sec><jats:title>Introduction</jats:title><jats:p>The efficacy of multitarget neuroprotective drug DL-3-n-butylphthalide (NBP) in improving cognitive function has been confirmed in patients with vascular cognitive impairment without dementia. However, its efficacy in patients with symptomatic predementia phase of Alzheimer’s disease remains uncertain. This study aims to evaluate the efficacy and safety of NBP in improving cognitive function in patients with mild cognitive impairment (MCI) through a clinical randomised controlled trail.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>This study is a 12-month, randomised, double-blind, placebo-controlled, multicentric trial, involving 270 patients with MCI. Subjects are randomly assigned to receive either NBP soft capsule (200 mg, three times per day) or placebo with an allocation ratio of 1:1. The efficacy and safety of NBP are assessed by comparing the results of neuropsychological, neuroimaging and laboratory tests between the two groups. The primary endpoint is the change in Alzheimer’s Disease Assessment Scale-Cognitive Subscale after 12 months. All patients will be monitored for adverse events.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>This study involving human participants has been reviewed and approved by Ethics Committee of Xuan Wu Hospital (No.2017058). The participants provide their written informed consent to participate in this study. Results will be published in peer-reviewed medical journals and disseminated to healthcare professionals at local and international conferences.</jats:p></jats:sec><jats:sec><jats:title>Protocol version</jats:title><jats:p>V 3.0, 3 September 2022.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p>ChiCTR1800018362.</jats:p></jats:sec>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002963/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
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                "PubMed CNS Regenerate"
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                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
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            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
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            ],
            "publisher": "BMJ",
            "container_title": "BMJ Open",
            "authors": [
                {
                    "author_id": 290305,
                    "given_name": "Pin",
                    "family_name": "Wang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359768,
                    "given_name": "Wenxian",
                    "family_name": "Sun",
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                },
                {
                    "author_id": 299198,
                    "given_name": "Jin",
                    "family_name": "Gong",
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                {
                    "author_id": 359769,
                    "given_name": "Xiaodong",
                    "family_name": "Han",
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                },
                {
                    "author_id": 359770,
                    "given_name": "Chang",
                    "family_name": "Xu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 345924,
                    "given_name": "Yufei",
                    "family_name": "Chen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 263766,
                    "given_name": "Yuting",
                    "family_name": "Yang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359771,
                    "given_name": "Heya",
                    "family_name": "Luan",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359772,
                    "given_name": "Shaoqi",
                    "family_name": "Li",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359773,
                    "given_name": "Ruina",
                    "family_name": "Li",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359774,
                    "given_name": "Boye",
                    "family_name": "Wen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359775,
                    "given_name": "Sirong",
                    "family_name": "Lv",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359776,
                    "given_name": "Cuibai",
                    "family_name": "Wei",
                    "ORCID": "http://orcid.org/0009-0004-7380-7451",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:25:10.589835Z",
            "article_subject_relevances": [],
            "doi": "10.1136/bmjopen-2023-082404",
            "access": "open",
            "takeaways": "DL-3-n-butylphthalide (NBP) is a neuroprotective drug. This study is a 12-month, randomised, double-blind, placebo-controlled, multicentric trial involving 270 patients with mild cognitive impairment (MCI). The primary endpoint is the change in Alzheimer’s Disease Assessment Scale-Cognitive Subscale after 12 months. All patients will be monitored for adverse events.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285838,
            "title": "Evaluating Sexual Health in Women with Multiple Sclerosis: A Study on the Interplay of Disability and Quality of Life",
            "summary": "<jats:p>In the context of evolving perceptions of sexuality, particularly within the realm of health and disability, this study investigates the impact of multiple sclerosis (MS) on female sexual function and quality of life. A quantitative study involving 130 female MS patients aged 35 to 50 was conducted, employing measures such as The Female Sexual Function Index (FSFI), The Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19), and The Fatigue Severity Scale (FSS). Results indicate a significant association between greater sexual dysfunction and poorer quality of sex life, alongside the correlation of increased fatigue with diminished sexual satisfaction. Specifically, the mean FSFI score was 20.8 (SD = 9.36), with 83.8% of participants experiencing severe fatigue (FSS score ≥ 36). Sexual dysfunction demonstrated a strong, negative correlation with all FSFI subscales (p &lt; 0.01). Factors such as education level (p = 0.016), time of diagnosis (p = 0.035), and treatment regimen (p = 0.041) also significantly influenced outcomes. Findings underscore the importance of supportive interventions, including counseling, to enhance the quality of sex life for women with disabilities, particularly those with MS.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38998774/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "Healthcare",
            "authors": [
                {
                    "author_id": 359759,
                    "given_name": "Panagiota",
                    "family_name": "Dourou",
                    "ORCID": "http://orcid.org/0000-0002-7434-8136",
                    "country": null
                },
                {
                    "author_id": 359760,
                    "given_name": "Kleanthi",
                    "family_name": "Gourounti",
                    "ORCID": "http://orcid.org/0000-0002-2365-415X",
                    "country": null
                },
                {
                    "author_id": 359761,
                    "given_name": "Aikaterini",
                    "family_name": "Lykeridou",
                    "ORCID": "http://orcid.org/0000-0002-0674-2414",
                    "country": null
                },
                {
                    "author_id": 359762,
                    "given_name": "Konstantina",
                    "family_name": "Gaitanou",
                    "ORCID": "http://orcid.org/0000-0002-4615-123X",
                    "country": null
                },
                {
                    "author_id": 359763,
                    "given_name": "Nikolaos",
                    "family_name": "Petrogiannis",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359764,
                    "given_name": "Chrysoula Rozalia",
                    "family_name": "Athanasiadou",
                    "ORCID": "http://orcid.org/0009-0000-3903-1478",
                    "country": null
                },
                {
                    "author_id": 359765,
                    "given_name": "Aikaterini",
                    "family_name": "Sousamli",
                    "ORCID": "http://orcid.org/0009-0001-1653-5398",
                    "country": null
                },
                {
                    "author_id": 359766,
                    "given_name": "Theodoros",
                    "family_name": "Xanthos",
                    "ORCID": "http://orcid.org/0000-0003-3670-9305",
                    "country": null
                },
                {
                    "author_id": 359767,
                    "given_name": "Antigoni",
                    "family_name": "Sarantaki",
                    "ORCID": "http://orcid.org/0000-0003-3316-8566",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:34.384114Z",
            "article_subject_relevances": [],
            "doi": "10.3390/healthcare12131239",
            "access": "open",
            "takeaways": "Study investigates the impact of multiple sclerosis (MS) on female sexual function and quality of life in 130 female MS patients aged 35 to 50. Results indicate a significant association between greater sexual dysfunction and poorer quality of sex life.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285837,
            "title": "TNF-alfa Gene Polymorphism Associations with Multiple Sclerosis",
            "summary": "<jats:p>Background: TNF-α has a dual role in multiple sclerosis (MS), contributing to both protective and harmful effects. It activates immune cells, promotes the formation of inflammatory lesions in the central nervous system, and stimulates the production of other pro-inflammatory cytokines and chemokines, leading to myelin destruction and neuronal damage. Our research focused on investigating the relationship between TNF-alpha (rs1800630, rs1800629, and rs361525) gene polymorphisms and MS. Methods: 250 healthy controls and 250 multiple sclerosis (MS) patients were included in the study. DNA was extracted from leucocytes from peripheral venous blood by salt precipitation. Single nucleotide polymorphisms (SNPs) were tested using RT–PCR. Statistical analysis of the data was performed using IBM SPSS Statistics 29.0 data analysis software. Results: The analysis revealed that the rs361525 AG genotype was significantly less frequent in the MS group compared to the control group (4.0% vs. 7.2%, p = 0.042). Sex-specific analysis showed a significant difference in genotype distribution (GG, AG, AA) among males between the MS group and the control group (97.7%, 0%, 2.3% vs. 90.6%, 9.4%, 0%, p = 0.005). For the rs1800629 polymorphism, significant results were also found. In subjects younger than 39 years, the A allele was significantly less frequent in the MS group than in the control group (8.6% vs. 15.0%, p = 0.030). The most robust model indicated that the AA genotype reduced the odds of MS by approximately 2 fold compared to the AG + GG genotype (p = 0.044), and each A allele reduced the odds of MS by approximately 2 fold (p = 0.028). The rs1800630 A allele was significantly more common in males in the MS group than in the control group (21.0% vs. 12.9%, p = 0.046). Conclusions: In conclusion, our study identifies significant associations between TNF-alpha gene variants and MS. Specifically, the rs631525 AG genotype was less common in the MS group, with notable sex-specific differences observed. The rs1800629 A allele was statistically significantly less frequent in the MS group than in the control group, and the AA genotype reduced the odds of MS occurrence by ~2 fold compared with the AG + GG genotypes. Additionally, each A allele of rs1800629 was linked to a 2-fold decreased odds of MS occurrence. In males, the rs1800630 A allele was more frequent in the MS group. These findings highlight the relevance of TNF-alpha genetic variations in MS susceptibility, suggesting potential avenues for further research and therapeutic exploration.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38999258/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "Journal of Clinical Medicine",
            "authors": [
                {
                    "author_id": 359758,
                    "given_name": "Lukas",
                    "family_name": "Kalvaitis",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 327721,
                    "given_name": "Greta",
                    "family_name": "Gedvilaite",
                    "ORCID": "http://orcid.org/0000-0001-7469-8825",
                    "country": null
                },
                {
                    "author_id": 266288,
                    "given_name": "Loresa",
                    "family_name": "Kriauciuniene",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 349192,
                    "given_name": "Renata",
                    "family_name": "Balnyte",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 266290,
                    "given_name": "Rasa",
                    "family_name": "Liutkeviciene",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:33.185387Z",
            "article_subject_relevances": [],
            "doi": "10.3390/jcm13133693",
            "access": "open",
            "takeaways": "TNF-α has a dual role in MS. 250 healthy controls and 250 MS patients were included in the study. DNA was extracted from leucocytes from peripheral venous blood by salt precipitation. Single nucleotide polymorphisms (SNPs) were tested using RT–PCR. The analysis revealed that the rs361525 AG genotype was significantly less frequent in the MS group compared to the control group. The AA genotype reduced the odds of MS by approximately 2 fold.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285836,
            "title": "Attention-Deficit Hyperactivity Disorder Symptoms in Adults Diagnosed with Multiple Sclerosis: Prevalence and Correlates",
            "summary": "<jats:p>Background: The relationship between adult ADHD symptoms in People with Multiple Sclerosis (PwMS) is understudied. This study aimed to answer two questions: are PwMS more likely to experience higher ADHD symptoms versus healthy subjects? And what are the correlates of severe ADHD symptoms in PwMS? Methods: This study followed a cross-sectional design with predefined inclusion criteria. The Adult ADHD Self-Report Scale-V1.1 (ASRS) was used to assess the ADHD symptoms severity. Results: Data were analyzed from 171 PwMS and 200 controls. Regression analysis revealed that PwMS were at a significantly (B = 3.05, t = 2.24, 95% CI = 0.37–5.73, p = 0.02) higher risk to report higher ADHD scores versus controls. In addition, PwMS with relapses in the last 6 months and PwMS reporting smartphone addiction were at a significantly higher risk for severe ADHD (B = 7.19, t = 269, 95% CI = 1.91–12.48, p = 0.008) and (B = 9.18, t = 3.47, 95% CI = 3.97–14.41, p = 0.001), respectively. In conclusion, diagnosis with MS in our study was identified as a risk for higher ADHD symptoms. Conclusions: Further research is required to establish this relationship, and holistic medical and psychological interventions are required to improve the cognitive status of PwMS.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38999410/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "Journal of Clinical Medicine",
            "authors": [
                {
                    "author_id": 359753,
                    "given_name": "Mariam",
                    "family_name": "Al-Ameri",
                    "ORCID": "http://orcid.org/0000-0002-1369-6620",
                    "country": null
                },
                {
                    "author_id": 359754,
                    "given_name": "Hanan",
                    "family_name": "Abu-Shaikh",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 351656,
                    "given_name": "Mohammad",
                    "family_name": "Mansour",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359755,
                    "given_name": "Suha",
                    "family_name": "Al-Habahbeh",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309211,
                    "given_name": "Feras",
                    "family_name": "Weshah",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 290736,
                    "given_name": "Wail",
                    "family_name": "Ennab",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359756,
                    "given_name": "Ammena Y.",
                    "family_name": "Binsaleh",
                    "ORCID": "http://orcid.org/0009-0007-7174-3839",
                    "country": null
                },
                {
                    "author_id": 359757,
                    "given_name": "Sireen Abdul Rahim",
                    "family_name": "Shilbayeh",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 191905,
                    "given_name": "Omar",
                    "family_name": "Gammoh",
                    "ORCID": "http://orcid.org/0000-0001-8801-2652",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:31.867398Z",
            "article_subject_relevances": [],
            "doi": "10.3390/jcm13133844",
            "access": "open",
            "takeaways": "People with Multiple Sclerosis (PwMS) are more likely to have higher ADHD symptoms than healthy subjects. PwMS with relapses in the last 6 months and with smartphone addiction were at a significantly higher risk for severe ADHD.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285835,
            "title": "Ultrastructural Characterization of PBMCs and Extracellular Vesicles in Multiple Sclerosis: A Pilot Study",
            "summary": "<jats:p>Growing evidence identifies extracellular vesicles (EVs) as important cell-to-cell signal transducers in autoimmune disorders, including multiple sclerosis (MS). If the etiology of MS still remains unknown, its molecular physiology has been well studied, indicating peripheral blood mononuclear cells (PBMCs) as the main pathologically relevant contributors to the disease and to neuroinflammation. Recently, several studies have suggested the involvement of EVs as key mediators of neuroimmune crosstalk in central nervous system (CNS) autoimmunity. To assess the role of EVs in MS, we applied electron microscopy (EM) techniques and Western blot analysis to study the morphology and content of plasma-derived EVs as well as the ultrastructure of PBMCs, considering four MS patients and four healthy controls. Through its exploratory nature, our study was able to detect significant differences between groups. Pseudopods and large vesicles were more numerous at the plasmalemma interface of cases, as were endoplasmic vesicles, resulting in an activated aspect of the PBMCs. Moreover, PBMCs from MS patients also showed an increased number of multivesicular bodies within the cytoplasm and amorphous material around the vesicles. In addition, we observed a high number of plasma-membrane-covered extensions, with multiple associated large vesicles and numerous autophagosomal vacuoles containing undigested cytoplasmic material. Finally, the study of EV cargo evidenced a number of dysregulated molecules in MS patients, including GANAB, IFI35, Cortactin, Septin 2, Cofilin 1, and ARHGDIA, that serve as inflammatory signals in a context of altered vesicular dynamics. We concluded that EM coupled with Western blot analysis applied to PBMCs and vesiculation can enhance our knowledge in the physiopathology of MS.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38999977/?fc=20210216052009&ff=20240713192812&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "MDPI AG",
            "container_title": "International Journal of Molecular Sciences",
            "authors": [
                {
                    "author_id": 175501,
                    "given_name": "Roberto",
                    "family_name": "De Masi",
                    "ORCID": "http://orcid.org/0000-0002-7587-8112",
                    "country": null
                },
                {
                    "author_id": 175502,
                    "given_name": "Stefania",
                    "family_name": "Orlando",
                    "ORCID": "http://orcid.org/0000-0003-2403-9228",
                    "country": null
                },
                {
                    "author_id": 359751,
                    "given_name": "Elisabetta",
                    "family_name": "Carata",
                    "ORCID": "http://orcid.org/0000-0002-3801-5457",
                    "country": null
                },
                {
                    "author_id": 359752,
                    "given_name": "Elisa",
                    "family_name": "Panzarini",
                    "ORCID": "http://orcid.org/0000-0003-4219-4272",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-13T23:28:30.692435Z",
            "article_subject_relevances": [],
            "doi": "10.3390/ijms25136867",
            "access": "open",
            "takeaways": "Extracellular vesicles (EVs) are important cell-to-cell signal transducers in autoimmune disorders, including multiple sclerosis (MS). The etiology of MS still remains unknown. The study compared four MS patients and four healthy controls and found significant differences between groups.",
            "team_categories": [],
            "ml_predictions": []
        }
    ]
}