{"count":23919,"next":"http://api.gregory-ms.com/articles/?page=1348","previous":"http://api.gregory-ms.com/articles/?page=1346","results":[{"article_id":382859,"title":"Effects of Mesenchymal Stem Cell Transplantation on Cerebrospinal Fluid Biomarkers in Progressive Multiple Sclerosis","summary":"CONCLUSIONS: Our findings indicate possible neuroprotective effects of MSC transplantation in patients with MS.","link":"https://pubmed.ncbi.nlm.nih.gov/35641166/?fc=20210216052009&ff=20220601092645&v=2.17.6","published_date":"2022-05-31T10:00:00Z","source":"PubMed","publisher":"Oxford University Press (OUP)","container_title":"Stem Cells Translational Medicine","authors":[{"author_id":176826,"given_name":"Panayiota","family_name":"Petrou","ORCID":"http://orcid.org/0000-0003-3765-6292","country":null},{"author_id":242394,"given_name":"Ibrahim","family_name":"Kassis","ORCID":null,"country":null},{"author_id":207524,"given_name":"Ariel","family_name":"Ginzberg","ORCID":"http://orcid.org/0000-0002-3667-0116","country":null},{"author_id":299358,"given_name":"Michelle","family_name":"Hallimi","ORCID":null,"country":null},{"author_id":207526,"given_name":"Dimitrios","family_name":"Karussis","ORCID":"http://orcid.org/0000-0001-5529-1237","country":null}],"relevant":true,"ml_prediction_gnb":true,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T13:26:46.464899Z","noun_phrases":["Effects","Mesenchymal Stem Cell Transplantation","Cerebrospinal Fluid Biomarkers","Progressive Multiple Sclerosis"],"doi":"10.1093/stcltm/szab017","access":"open","takeaways":"","categories":[]},{"article_id":382858,"title":"Autophagy Modulation in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis","summary":"Multiple sclerosis (MS), a white matter demyelinating disease of the central nervous system (CNS), is characterized by the neuroinflammatory and neurodegenerative. Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model for investigating pathogenic mechanisms of MS, representing the destruction of the blood-brain barrier (BBB), the activation of T cells, and the infiltration of myeloid cells. An increasing number of studies have documented that autophagy plays a critical...","link":"https://pubmed.ncbi.nlm.nih.gov/35641229/?fc=20210216052009&ff=20220601092645&v=2.17.6","published_date":"2022-05-31T10:00:00Z","source":"PubMed","publisher":"Oxford University Press (OUP)","container_title":"Clinical and Experimental Immunology","authors":[{"author_id":218827,"given_name":"Donghui","family_name":"Shen","ORCID":"http://orcid.org/0000-0002-3529-9693","country":null},{"author_id":294400,"given_name":"Kang","family_name":"Liu","ORCID":null,"country":null},{"author_id":253897,"given_name":"Hongyan","family_name":"Wang","ORCID":null,"country":null},{"author_id":294404,"given_name":"Haifeng","family_name":"Wang","ORCID":null,"country":null}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T13:26:46.464102Z","noun_phrases":["Autophagy Modulation","Multiple Sclerosis","Experimental Autoimmune Encephalomyelitis"],"doi":"10.1093/cei/uxac017","access":"open","takeaways":" Multiple sclerosis (MS) is a white matter demyelinating disease of the central nervous system . It is characterized by the neuroinflammatory and neurodegener","categories":[]},{"article_id":382857,"title":"Ageing reduces potential for remyelination in multiple sclerosis","summary":"No abstract available","link":"https://pubmed.ncbi.nlm.nih.gov/35641684/?fc=20210216052009&ff=20220601092645&v=2.17.6","published_date":"2022-05-31T10:00:00Z","source":"PubMed","publisher":"Springer Science and Business Media LLC","container_title":"Nature Reviews Neurology","authors":[{"author_id":251952,"given_name":"Ian","family_name":"Fyfe","ORCID":null,"country":null}],"relevant":false,"ml_prediction_gnb":true,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T13:26:46.463347Z","noun_phrases":["Ageing","potential","remyelination","multiple sclerosis"],"doi":"10.1038/s41582-022-00680-3","access":"restricted","takeaways":"","categories":[]},{"article_id":382856,"title":"Protocol for the development of a core outcome set for evaluating mixed-diagnosis falls prevention interventions for people with Multiple Sclerosis, Parkinson's Disease and stroke","summary":"Background: Given the high incidence of falls and their associated negative effects, the development of effective falls prevention interventions for people with Multiple Sclerosis (MS), Parkinson's Disease (PD) and stroke is a priority. Currently the implementation of condition-specific falls prevention interventions is challenging in the community due to lack of participants and resources. Given the similarities in falls risk factors across stroke, PD and MS, the design of mixed-diagnosis...","link":"https://pubmed.ncbi.nlm.nih.gov/35633846/?fc=20210216052009&ff=20220601092645&v=2.17.6","published_date":"2022-06-01T10:00:00Z","source":"PubMed","publisher":"F1000 Research Ltd","container_title":"HRB Open Research","authors":[{"author_id":171987,"given_name":"Nicola","family_name":"O'Malley","ORCID":"http://orcid.org/0000-0001-9540-1090","country":null},{"author_id":237031,"given_name":"Susan","family_name":"Coote","ORCID":null,"country":null},{"author_id":171988,"given_name":"Amanda M","family_name":"Clifford","ORCID":"http://orcid.org/0000-0003-0917-419X","country":null}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T13:26:46.462484Z","noun_phrases":["Protocol","the development","a core outcome","mixed-diagnosis","prevention interventions","people","Multiple Sclerosis","Parkinson's Disease","stroke"],"doi":"10.12688/hrbopenres.13459.2","access":"open","takeaways":" The development of effective falls prevention interventions for people with MS, PD and stroke is a priority . Currently the implementation of condition-specific falls prevention . interventions is","categories":[]},{"article_id":382855,"title":"Mutation Screening of TFG in α-Synucleinopathy and Amyotrophic Lateral Sclerosis","summary":"CONCLUSIONS: Rare variants of TFG were not enriched in α-synucleinopathy and ALS. However, we could not deny the potential pathogenicity of specific variants such as p.R383H. Further exploration is still necessary. © 2022 International Parkinson and Movement Disorder Society.","link":"https://pubmed.ncbi.nlm.nih.gov/35642252/?fc=20210216052009&ff=20220601092645&v=2.17.6","published_date":"2022-06-01T10:00:00Z","source":"PubMed","publisher":"Wiley","container_title":"Movement Disorders","authors":[{"author_id":243049,"given_name":"Chunyu","family_name":"Li","ORCID":null,"country":null},{"author_id":199545,"given_name":"Junyu","family_name":"Lin","ORCID":"http://orcid.org/0000-0001-5956-8301","country":null},{"author_id":199546,"given_name":"Xiaojing","family_name":"Gu","ORCID":"http://orcid.org/0000-0002-9023-725X","country":null},{"author_id":243058,"given_name":"Yanbing","family_name":"Hou","ORCID":null,"country":null},{"author_id":199547,"given_name":"Kuncheng","family_name":"Liu","ORCID":"http://orcid.org/0000-0003-2671-2201","country":null},{"author_id":243052,"given_name":"Qirui","family_name":"Jiang","ORCID":null,"country":null},{"author_id":243069,"given_name":"Ruwei","family_name":"Ou","ORCID":null,"country":null},{"author_id":243060,"given_name":"Qianqian","family_name":"Wei","ORCID":null,"country":null},{"author_id":243072,"given_name":"Xueping","family_name":"Chen","ORCID":null,"country":null},{"author_id":243076,"given_name":"Bi","family_name":"Zhao","ORCID":null,"country":null},{"author_id":214911,"given_name":"Ying","family_name":"Wu","ORCID":"http://orcid.org/0000-0003-2006-7491","country":null},{"author_id":295249,"given_name":"Yongping","family_name":"Chen","ORCID":null,"country":null},{"author_id":148372,"given_name":"Huifang","family_name":"Shang","ORCID":"http://orcid.org/0000-0003-0947-1151","country":null},{"author_id":332025,"given_name":"Wei","family_name":"Song","ORCID":"http://orcid.org/0000-0001-9482-7188","country":null}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T13:26:45.637166Z","noun_phrases":["Mutation Screening","TFG","Amyotrophic Lateral Sclerosis"],"doi":"10.1002/mds.29079","access":"restricted","takeaways":"","categories":[]},{"article_id":382586,"title":"Human herpesvirus 6B infection in mesial temporal lobe epilepsy: a meta-analysis","summary":"Abstract\nBackground\nWhether human herpesvirus 6B (HHV-6B) can affect mesial temporal lobe epilepsy (MTLE) remains controversial. The present meta-analysis was aimed to evaluate whether HHV-6B is significantly associated with MTLE.\n\nMethods\nSix studies were included in this meta-analysis, comprising 183 MTLE patients and 75 controls. In these studies, HHV-6B infection in astrocytes and brain samples of MTLE patients and controls was investigated by polymerase chain reaction and immunofluorescence.\n\nResults\nThe frequency of HHV-6B infection detection is significantly higher in the MTLE group than in the control group (OR = 9.42, 95%CI: 3.66–24.25), P < 0.00001). Although febrile convulsion is strongly associated with MTLE, the formation of febrile convulsion leading to MTLE is not associated with HHV-6B infection (OR = 2.68, 95%CI: 0.93–7.73), P = 0.07). Moreover, the HHV-6B-specific antigen is co-localized to cells positive for GFAP that morphologically resemble astrocytes. HHV-6B mainly infects astrocytes, oligodendrocytes and microglia, and could damage the vascular endothelial cells of the central nervous system.\n\nConclusions\nThere is an association between HHV-6B infection and MTLE. Future large-scale, multi-center, controlled, prospective studies are required to confirm these findings. In addition, the exact mechanism underlying the effects of HHV-6B infection on MTLE needs to be further investigated.\n","link":"https://aepi.biomedcentral.com/articles/10.1186/s42494-022-00083-3","published_date":"2022-05-31T23:00:00Z","source":"BioMedCentral","publisher":"Springer Science and Business Media LLC","container_title":"Acta Epileptologica","authors":[{"author_id":245396,"given_name":"Jingyi","family_name":"Tong","ORCID":null,"country":null},{"author_id":245397,"given_name":"Qin","family_name":"Zou","ORCID":null,"country":null},{"author_id":176423,"given_name":"Sheng","family_name":"Wang","ORCID":"http://orcid.org/0000-0003-4176-8844","country":null},{"author_id":249213,"given_name":"Jiaqi","family_name":"Liu","ORCID":null,"country":null},{"author_id":243268,"given_name":"Rong","family_name":"Chen","ORCID":null,"country":null},{"author_id":245398,"given_name":"Yongmin","family_name":"Chen","ORCID":null,"country":null},{"author_id":249214,"given_name":"Wenjie","family_name":"Zhao","ORCID":null,"country":null},{"author_id":245400,"given_name":"Lin","family_name":"Ma","ORCID":null,"country":null},{"author_id":152858,"given_name":"Qifu","family_name":"Li","ORCID":"http://orcid.org/0000-0003-3904-410X","country":null}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T06:04:45.814578Z","noun_phrases":["Human herpesvirus 6B infection","mesial temporal lobe epilepsy","a meta-analysis"],"doi":"10.1186/s42494-022-00083-3","access":"open","takeaways":" The frequency of HHV-6B infection detection is significantly higher in the MTLE group than in the control group . Although febrile convulsion is strongly associated with MTLE, the formation of febria convulsion leading to MTLE is not associated with infection . Future large-scale, multi-center, controlled, prospective studies are required to confirm these findings .","categories":[]},{"article_id":382585,"title":"Causal mechanisms of a scapular stabilization intervention for patients with subacromial pain syndrome: a secondary analysis of a randomized controlled trial","summary":"Abstract\n Background\n Causal mediation analysis is one way to bridge this gap by exploring the causal pathways of a given intervention. The aim of this study was to assess whether scapular motion, position, and periscapular muscle strength are mediators for pain and shoulder disability outcomes following a scapular stabilization intervention for patients with subacromial pain syndrome.\n \n Methods\n Sixty patients were randomized into two groups: scapular stabilization or periscapular strengthening exercises. The intervention consisted of three sessions per week for 8 weeks. The primary outcome measures were pain and disability and the following outcome measures were considered as potential mediators: scapular motion, scapular position, periscapular muscle strength, age, duration of symptoms, and side of the complaint. A model-based inference approach with bootstrap simulations was used to estimate the average causal mediation effect, average direct effect, and the average total effect from the data of a randomized clinical trial that evaluated the effect of adding scapular stabilization exercises to a scapulothoracic strengthening program in people with subacromial pain syndrome.\n \n Results\n The results demonstrated that none of the putative mediators were influenced by the intervention. However, muscle strength of serratus anterior, upper, middle, and lower trapezius muscles was associated with shoulder disability.\n \n Conclusion\n Scapular kinematic and periscapular muscle strength did not mediate the effect of scapular stabilization exercises on shoulder pain or disability scores in subjects with subacromial pain syndrome. Muscle strength of serratus anterior, upper, middle and lower trapezius were associated with shoulder disability scores at 8-weeks follow-up.\n ","link":"https://archivesphysiotherapy.biomedcentral.com/articles/10.1186/s40945-022-00138-1","published_date":"2022-05-31T23:00:00Z","source":"BioMedCentral","publisher":"Springer Science and Business Media LLC","container_title":"Archives of Physiotherapy","authors":[{"author_id":309477,"given_name":"Gisele Harumi","family_name":"Hotta","ORCID":null,"country":null},{"author_id":309478,"given_name":"Rafael Krasic","family_name":"Alaiti","ORCID":null,"country":null},{"author_id":309479,"given_name":"Daniel Cury","family_name":"Ribeiro","ORCID":null,"country":null},{"author_id":309480,"given_name":"Kevin James","family_name":"McQuade","ORCID":null,"country":null},{"author_id":309481,"given_name":"Anamaria Siriani","family_name":"de Oliveira","ORCID":null,"country":null}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T06:04:45.812813Z","noun_phrases":["Causal mechanisms","a scapular stabilization intervention","patients","subacromial pain syndrome","a secondary analysis","a randomized controlled trial"],"doi":"10.1186/s40945-022-00138-1","access":"open","takeaways":" Sixty patients were randomized into two groups: scapular stabilization or periscapular strengthening exercises . Muscle strength of serratus anterior, upper, middle and lower trapezius muscles was associated with shoulder disability at 8-weeks follow-up .","categories":[]},{"article_id":382437,"title":"Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms","summary":"Abstract\n Background\n The objectives of this study were to delineate whether delirium in older adults is associated with activation of the immune-inflammatory response system (IRS) as indicated by activation of M1, T helper (Th)1, and Th17 profiles, and/or by reduced activities of the compensatory immunoregulatory system (CIRS), including Th2 and T regulatory profiles.\n \n Methods\n We recruited 65 older adult patients with a low energy impact hip fracture who underwent hip fracture operation. The CAM-ICU and the Delirium Rating Scale, Revised-98-Thai version (DRS-R-98) were assessed pre-operatively and 1, 2 and 3 days after surgery. Blood samples (day 1 and 2) post-surgery were assayed for cytokines/chemokines using a MultiPlex assay and the neutrophil/lymphocyte ratio.\n \n Results\n We found that delirium and/or the DRS-R-98 score were associated with IRS activation as indicated by activated M1, Th1, Th17 and T cell growth profiles and by attenuated CIRS functions. The most important IRS biomarkers were CXCL8, interleukin (IL)-6, and tumor necrosis factor-α, and the most important CIRS biomarkers were IL-4 and soluble IL-1 receptor antagonist. We found that 42.5% of the variance in the actual changes in the DRS-R-98 score (averaged from day 1 to day 3) was explained by T cell growth factors, baseline DRS-R-98 scores and age. An increase in the NLR reflects overall IRS, M1, Th1, Th17, and Th2 activation.\n \n Conclusions\n Post-hip surgery delirium is associated with activated IRS pathways and appears especially in patients with lowered CIRS functions.\n ","link":"https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-022-04021-y","published_date":"2022-05-30T23:00:00Z","source":"BioMedCentral","publisher":"Springer Science and Business Media LLC","container_title":"BMC Psychiatry","authors":[{"author_id":261253,"given_name":"Paul","family_name":"Thisayakorn","ORCID":null,"country":null},{"author_id":261254,"given_name":"Yanin","family_name":"Thipakorn","ORCID":null,"country":null},{"author_id":261256,"given_name":"Saran","family_name":"Tantavisut","ORCID":null,"country":null},{"author_id":261257,"given_name":"Sunee","family_name":"Sirivichayakul","ORCID":null,"country":null},{"author_id":155469,"given_name":"Michael","family_name":"Maes","ORCID":"http://orcid.org/0000-0002-2012-871X","country":"TH"}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-06-01T02:04:45.768541Z","noun_phrases":["Delirium","hip fracture","activated immune-inflammatory pathways","a reduction","negative immunoregulatory mechanisms"],"doi":"10.1186/s12888-022-04021-y","access":"open","takeaways":" The CAM-ICU and the Delirium Rating Scale, Revised-98-Thai version (DRS-R-98) were assessed pre-operatively and 1, 2 and 3 days after surgery . The most important IRS biomarkers were CXCL8, interleukin (IL)-6, and tumor necrosis factor-α .","categories":[]},{"article_id":382165,"title":"Patient involvement in rare diseases research: a scoping review of the literature and mixed method evaluation of Norwegian researchers’ experiences and perceptions","summary":"Abstract\n Background\n Patients’ involvement (PI) in research is recognized as a valuable strategy for increasing the quality, developing more targeted research and to speed up more innovative research dissemination. Nevertheless, patient involvement in rare diseases research (PI-RDR) is scarce. The aims were: To study the Norwegian researchers` experiences and perceptions of PI-RDR and review the literature on PI-RDR.\n \n Methods\n 1. A systematic scoping review of the literature on PI-RDR. 2. A cross-sectional questionnaire study with close-ended and open-ended questions to investigate the researchers` experiences.\n \n Results\n In the scoping review 608 articles read in full-text and 13 articles (one review and twelve primary studies) were included. The heterogeneity of the design, methodology and results was large. Most studies described several benefits of PI, but few described methods for measuring impacts and effectiveness of PI-RDR. In the cross sectional part of this study, 145 of 251 employees working in the nine Norwegian Centers on Rare Diseases participated, of these 69 were researchers. Most (95%) of the researchers claimed that rare diseases research is more challenging than for the more common diseases. The majority (95%) argued that PI-RDR may increase the quality of the studies and the relevance, and most (89%) agreed that PI-RDR in dissemination may increase the awareness and public interest for rare diseases. In the open-ended questions several researchers also claimed challenges related to PI-RDR, and many had proposal for improving PI and promotion of rare disease research.\n \n Conclusion\n Both the literature and researchers emphasized that PI-RDR is important for improving research quality and increase the public attention on rare diseases, but what constitutes effective PI-RDR still remain unclear. More research on the design, methodology and assessment for measuring the impact of PI-RDR is warranted.\n ","link":"https://ojrd.biomedcentral.com/articles/10.1186/s13023-022-02357-y","published_date":"2022-05-30T23:00:00Z","source":"BioMedCentral","publisher":"Springer Science and Business Media LLC","container_title":"Orphanet Journal of Rare Diseases","authors":[{"author_id":227630,"given_name":"Gry","family_name":"Velvin","ORCID":"http://orcid.org/0000-0002-5521-778X","country":null},{"author_id":308717,"given_name":"Thale","family_name":"Hartman","ORCID":null,"country":null},{"author_id":228193,"given_name":"Trine","family_name":"Bathen","ORCID":"http://orcid.org/0000-0002-1339-9319","country":null}],"relevant":null,"ml_prediction_gnb":false,"ml_prediction_lr":false,"ml_prediction_lsvc":null,"discovery_date":"2022-05-31T18:04:45.743630Z","noun_phrases":["Patient involvement","rare diseases","a scoping review","the literature and mixed method evaluation","Norwegian researchers’ experiences","perceptions"],"doi":"10.1186/s13023-022-02357-y","access":"open","takeaways":" Patients’ involvement (PI) in research is recognized as a valuable strategy for increasing the quality, developing more targeted research and to speed up more innovative research dissemination . But patient involvement in rare diseases research (PI-RDR) is scarce . Most studies described several benefits of PI, but few described methods for measuring impacts and effectiveness .","categories":[]},{"article_id":381959,"title":"Default network activity is a sensitive and specific biomarker of memory in multiple sclerosis","summary":null,"link":"https://journals.sagepub.com/doi/full/10.1177/1352458512461391","published_date":"2012-06-08T00:00:00Z","source":"SAGE Publications","publisher":"SAGE Publications","container_title":"Multiple Sclerosis Journal","authors":[{"author_id":311723,"given_name":"J. F.","family_name":"Sumowski","ORCID":null,"country":null},{"author_id":311724,"given_name":"G. R.","family_name":"Wylie","ORCID":null,"country":null},{"author_id":311725,"given_name":"V. M.","family_name":"Leavitt","ORCID":null,"country":null},{"author_id":311726,"given_name":"N. D.","family_name":"Chiaravalloti","ORCID":null,"country":null},{"author_id":260292,"given_name":"J.","family_name":"DeLuca","ORCID":null,"country":null}],"relevant":null,"ml_prediction_gnb":null,"ml_prediction_lr":null,"ml_prediction_lsvc":null,"discovery_date":"2022-05-31T16:16:47.188873Z","noun_phrases":["Default network activity","a sensitive and specific biomarker","memory","multiple sclerosis"],"doi":"10.1177/1352458512448267","access":"restricted","takeaways":null,"categories":[]}]}