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{ "count": 24437, "next": "http://api.gregory-ms.com/articles/?format=api&page=5", "previous": "http://api.gregory-ms.com/articles/?format=api&page=3", "results": [ { "article_id": 283253, "title": "Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy", "summary": "Narcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the HLA-DQB1*06:02 allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The pathogenesis of narcolepsy is still not completely understood but the strong...", "link": "https://pubmed.ncbi.nlm.nih.gov/38663202/?fc=20210216052009&ff=20240426122532&v=2.18.0.post9+e462414", "published_date": "2024-04-25T10:00:00Z", "source": "PubMed", "publisher": "Elsevier BV", "container_title": "Journal of Autoimmunity", "authors": [ { "author_id": 349017, "given_name": "Alina", "family_name": "Huth", "ORCID": null, "country": null }, { "author_id": 349018, "given_name": "Ikram", "family_name": "Ayoub", "ORCID": null, "country": null }, { "author_id": 349019, "given_name": "Lucie", "family_name": "Barateau", "ORCID": null, "country": null }, { "author_id": 226933, "given_name": "Lisa Ann", "family_name": "Gerdes", "ORCID": "http://orcid.org/0000-0002-7053-3924", "country": null }, { "author_id": 349020, "given_name": "Dany", "family_name": "Severac", "ORCID": null, "country": null }, { "author_id": 349021, "given_name": "Stefan", "family_name": "Krebs", "ORCID": null, "country": null }, { "author_id": 349022, "given_name": "Helmut", "family_name": "Blum", "ORCID": null, "country": null }, { "author_id": 157222, "given_name": "Hayrettin", "family_name": "Tumani", "ORCID": "http://orcid.org/0000-0002-1647-6201", "country": null }, { "author_id": 346463, "given_name": "Jürgen", "family_name": "Haas", "ORCID": "http://orcid.org/0000-0002-2314-7465", "country": null }, { "author_id": 240370, "given_name": "Brigitte", "family_name": "Wildemann", "ORCID": null, "country": null }, { "author_id": 199738, "given_name": "Tania", "family_name": "Kümpfel", "ORCID": "http://orcid.org/0000-0001-7509-5268", "country": null }, { "author_id": 175285, "given_name": "Eduardo", "family_name": "Beltrán", "ORCID": "http://orcid.org/0000-0002-7266-4098", "country": null }, { "author_id": 349023, "given_name": "Roland S.", "family_name": "Liblau", "ORCID": null, "country": null }, { "author_id": 349024, "given_name": "Yves", "family_name": "Dauvilliers", "ORCID": null, "country": null }, { "author_id": 200750, "given_name": "Klaus", "family_name": "Dornmair", "ORCID": "http://orcid.org/0000-0003-0342-5373", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-26T05:25:37.997211Z", "noun_phrases": null, "doi": "10.1016/j.jaut.2024.103234", "access": "open", "takeaways": "Narcolepsy is a rare cause of hypersomnolence and may be associated with cataplexy. Most patients carry the HLA-D", "categories": [] }, { "article_id": 283252, "title": "Antigen-specific immunotherapy via delivery of tolerogenic dendritic cells for multiple sclerosis", "summary": "Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic...", "link": "https://pubmed.ncbi.nlm.nih.gov/38663308/?fc=20210216052009&ff=20240426122532&v=2.18.0.post9+e462414", "published_date": "2024-04-25T10:00:00Z", "source": "PubMed", "publisher": "Elsevier BV", "container_title": "Journal of Neuroimmunology", "authors": [ { "author_id": 168104, "given_name": "Vivien", "family_name": "Li", "ORCID": "http://orcid.org/0000-0001-9889-971X", "country": null }, { "author_id": 195698, "given_name": "Michele D.", "family_name": "Binder", "ORCID": "http://orcid.org/0000-0002-4494-6717", "country": "AU" }, { "author_id": 349016, "given_name": "Anthony W.", "family_name": "Purcell", "ORCID": null, "country": null }, { "author_id": 241007, "given_name": "Trevor J.", "family_name": "Kilpatrick", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-26T05:25:36.806591Z", "noun_phrases": null, "doi": "10.1016/j.jneuroim.2024.578347", "access": "restricted", "takeaways": "MS is a chronic inflammatory demyelinating disease of the central nervous system. Therapies for MS have broad immunosuppressive effects", "categories": [] }, { "article_id": 283251, "title": "An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study", "summary": "CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.", "link": "https://pubmed.ncbi.nlm.nih.gov/38663930/?fc=20210216052009&ff=20240426122532&v=2.18.0.post9+e462414", "published_date": "2024-04-25T10:00:00Z", "source": "PubMed", "publisher": "Impact Journals, LLC", "container_title": "Aging", "authors": [ { "author_id": 349010, "given_name": "Fei", "family_name": "Ren", "ORCID": null, "country": null }, { "author_id": 349011, "given_name": "Chenxuan", "family_name": "Yang", "ORCID": null, "country": null }, { "author_id": 349012, "given_name": "Kexin", "family_name": "Feng", "ORCID": null, "country": null }, { "author_id": 349013, "given_name": "Qingyao", "family_name": "Shang", "ORCID": null, "country": null }, { "author_id": 349014, "given_name": "Jiaxiang", "family_name": "Liu", "ORCID": null, "country": null }, { "author_id": 349015, "given_name": "Xiyu", "family_name": "Kang", "ORCID": null, "country": null }, { "author_id": 187746, "given_name": "Xin", "family_name": "Wang", "ORCID": "http://orcid.org/0000-0001-7242-357X", "country": null }, { "author_id": 258698, "given_name": "Xiang", "family_name": "Wang", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-26T05:25:35.428915Z", "noun_phrases": null, "doi": "10.18632/aging.205745", "access": "open", "takeaways": "There is a decreased risk of ER+ breast cancer in Alzheimer's patients and an increased risk in patients with multiple sclerosis. More prospective randomized controlled", "categories": [] }, { "article_id": 283250, "title": "Effects of microbiome-based interventions on neurodegenerative diseases: a systematic review and meta-analysis", "summary": "Neurodegenerative diseases (NDDs) are characterized by neuronal damage and progressive loss of neuron function. Microbiome-based interventions, such as dietary interventions, biotics, and fecal microbiome transplant, have been proposed as a novel approach to managing symptoms and modulating disease progression. Emerging clinical trials have investigated the efficacy of interventions modulating the GM in alleviating or reversing disease progression, yet no comprehensive synthesis have been done....", "link": "https://pubmed.ncbi.nlm.nih.gov/38664425/?fc=20210216052009&ff=20240426122532&v=2.18.0.post9+e462414", "published_date": "2024-04-25T10:00:00Z", "source": "PubMed", "publisher": "Springer Science and Business Media LLC", "container_title": "Scientific Reports", "authors": [ { "author_id": 349141, "given_name": "Zara Siu Wa", "family_name": "Chui", "ORCID": "http://orcid.org/0009-0001-3722-2374", "country": null }, { "author_id": 219406, "given_name": "Lily Man Lee", "family_name": "Chan", "ORCID": "http://orcid.org/0000-0003-3665-1449", "country": null }, { "author_id": 349142, "given_name": "Esther Wan Hei", "family_name": "Zhang", "ORCID": null, "country": null }, { "author_id": 349143, "given_name": "Suisha", "family_name": "Liang", "ORCID": "http://orcid.org/0000-0003-0426-9827", "country": null }, { "author_id": 349144, "given_name": "Edmond Pui Hang", "family_name": "Choi", "ORCID": "http://orcid.org/0000-0002-8388-7342", "country": "HK" }, { "author_id": 349145, "given_name": "Kris Yuet Wan", "family_name": "Lok", "ORCID": "http://orcid.org/0000-0002-3227-0799", "country": null }, { "author_id": 349146, "given_name": "Hein Min", "family_name": "Tun", "ORCID": "http://orcid.org/0000-0001-7597-5062", "country": null }, { "author_id": 219412, "given_name": "Jojo Yan Yan", "family_name": "Kwok", "ORCID": "http://orcid.org/0000-0001-7444-6935", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-26T05:25:34.500644Z", "noun_phrases": null, "doi": "10.1038/s41598-024-59250-w", "access": "restricted", "takeaways": "Neurodegenerative diseases (NDDs) are characterized by neuronal damage and progressive loss of neuron function. Microbiome-based", "categories": [] }, { "article_id": 283248, "title": "Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis", "summary": "BACKGROUND AND OBJECTIVES: Vidofludimus calcium suppressed MRI disease activity compared with placebo in patients with relapsing-remitting multiple sclerosis (RRMS) in the first cohort of the phase 2 EMPhASIS study. Because 30 mg and 45 mg showed comparable activity on multiple end points, the study enrolled an additional low-dose cohort to further investigate a dose-response relationship.", "link": "https://pubmed.ncbi.nlm.nih.gov/38662979/?fc=20210216052009&ff=20240426122532&v=2.18.0.post9+e462414", "published_date": "2024-04-25T10:00:00Z", "source": "PubMed", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "container_title": "Neurology Neuroimmunology & Neuroinflammation", "authors": [ { "author_id": 160394, "given_name": "Heinz", "family_name": "Wiendl", "ORCID": "http://orcid.org/0000-0003-4310-3432", "country": null }, { "author_id": 206989, "given_name": "Christian", "family_name": "Wolf", "ORCID": "http://orcid.org/0000-0002-4683-0507", "country": "BE" }, { "author_id": 150517, "given_name": "Nicola", "family_name": "De Stefano", "ORCID": "http://orcid.org/0000-0003-4930-7639", "country": "IT" }, { "author_id": 152356, "given_name": "Johann", "family_name": "Sellner", "ORCID": "http://orcid.org/0000-0001-8749-5533", "country": null }, { "author_id": 284758, "given_name": "Viktoriia", "family_name": "Gryb", "ORCID": null, "country": null }, { "author_id": 158273, "given_name": "Konrad", "family_name": "Rejdak", "ORCID": "http://orcid.org/0000-0002-7019-6681", "country": "PL" }, { "author_id": 349004, "given_name": "Plamen S.", "family_name": "Bozhinov", "ORCID": null, "country": null }, { "author_id": 349005, "given_name": "Daniel", "family_name": "Vitt", "ORCID": null, "country": null }, { "author_id": 349006, "given_name": "Hella", "family_name": "Kohlhof", "ORCID": null, "country": null }, { "author_id": 349007, "given_name": "Jason", "family_name": "Slizgi", "ORCID": null, "country": null }, { "author_id": 349008, "given_name": "Matej", "family_name": "Ondrus", "ORCID": null, "country": null }, { "author_id": 349009, "given_name": "Valentina", "family_name": "Sciacca", "ORCID": null, "country": null }, { "author_id": 284763, "given_name": "Andreas R.", "family_name": "Muehler", "ORCID": null, "country": null }, { "author_id": 143705, "given_name": "Robert J.", "family_name": "Fox", "ORCID": "http://orcid.org/0000-0002-4263-3717", "country": "US" } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-25T23:25:35.342620Z", "noun_phrases": null, "doi": "10.1212/NXI.0000000000200208", "access": "restricted", "takeaways": "Vidofludimus calcium suppressed MRI disease activity compared with placebo in patients with relapsing-rem", "categories": [] }, { "article_id": 283247, "title": "Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8\n <sup>+</sup>\n T-Cell Proliferation in Patients With Multiple Sclerosis", "summary": "BACKGROUND AND OBJECTIVES: The role of B cells in the pathogenic events leading to relapsing multiple sclerosis (R-MS) has only been recently elucidated. A pivotal step in defining this role has been provided by therapeutic efficacy of anti-CD20 monoclonal antibodies. Indeed, treatment with anti-CD20 can also alter number and function of other immune cells not directly expressing CD20 on their cell surface, whose activities can contribute to unknown aspects influencing therapeutic efficacy. We...", "link": "https://pubmed.ncbi.nlm.nih.gov/38662990/?fc=20210216052009&ff=20240426122532&v=2.18.0.post9+e462414", "published_date": "2024-04-25T10:00:00Z", "source": "PubMed", "publisher": "Ovid Technologies (Wolters Kluwer Health)", "container_title": "Neurology Neuroimmunology & Neuroinflammation", "authors": [ { "author_id": 177322, "given_name": "Gianmarco", "family_name": "Abbadessa", "ORCID": "http://orcid.org/0000-0001-8912-3055", "country": null }, { "author_id": 255846, "given_name": "Maria Teresa", "family_name": "Lepore", "ORCID": null, "country": null }, { "author_id": 271375, "given_name": "Sara", "family_name": "Bruzzaniti", "ORCID": null, "country": null }, { "author_id": 282143, "given_name": "Erica", "family_name": "Piemonte", "ORCID": null, "country": null }, { "author_id": 148574, "given_name": "Elisabetta", "family_name": "Signoriello", "ORCID": "http://orcid.org/0000-0001-5753-6752", "country": null }, { "author_id": 348997, "given_name": "Francesco", "family_name": "Perna", "ORCID": null, "country": null }, { "author_id": 348998, "given_name": "Chiara", "family_name": "De Falco", "ORCID": null, "country": null }, { "author_id": 148206, "given_name": "G.", "family_name": "Lus", "ORCID": "http://orcid.org/0000-0002-9457-1124", "country": null }, { "author_id": 178152, "given_name": "Giuseppe", "family_name": "Matarese", "ORCID": "http://orcid.org/0000-0001-9429-0616", "country": "IT" }, { "author_id": 148575, "given_name": "Simona", "family_name": "Bonavita", "ORCID": "http://orcid.org/0000-0002-8561-9720", "country": null }, { "author_id": 255851, "given_name": "Mario", "family_name": "Galgani", "ORCID": null, "country": null }, { "author_id": 152369, "given_name": "Giuseppina", "family_name": "Miele", "ORCID": "http://orcid.org/0000-0002-1910-5908", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-25T23:25:34.495973Z", "noun_phrases": null, "doi": "10.1212/NXI.0000000000200250", "access": "restricted", "takeaways": "The role of B cells in the pathogenic events leading to relapsing multiple sclerosis (R-MS) has only been recently elucidated. Treatment with anti-", "categories": [ { "category_id": 8, "category_description": "", "category_name": "Ocrelizumab", "category_slug": "ocrelizumab", "category_terms": [ "ocrelizumab", "ocrevus" ], "article_count": 226 }, { "category_id": 46, "category_description": "Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses. EBV is found all over the world. Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva. EBV can cause infectious mononucleosis, also called mono, and other illnesses.\r\n\r\nsource: <a href=\"https://www.cdc.gov/epstein-barr/about-ebv.html\">https://www.cdc.gov/epstein-barr/about-ebv.html</a>\r\n\r\nEBV may be a leading cause of multiple sclerosis. \r\nsource: <a href=\"https://www.nature.com/articles/s41582-023-00775-5\">https://www.nature.com/articles/s41582-023-00775-5</a>", "category_name": "Epstein-Barr Virus", "category_slug": "epstein-barr-virus", "category_terms": [ "ebv", "Epstein-Barr" ], "article_count": 161 } ] }, { "article_id": 283245, "title": "LINC complex alterations are a key feature of sporadic and familial ALS/FTD", "summary": "<jats:title>Abstract</jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research suggests that dysfunction of the nuclear envelope (NE) may contribute to disease pathogenesis and progression. The NE plays a role in ALS through several mechanisms, including nuclear pore defects, nucleocytoplasmic transport impairment, accumulation of mislocalized proteins, and nuclear morphology abnormalities. The LINC complex is the second biggest multi-protein complex in the NE and consists of the SUN1/2 proteins spanning the inner nuclear membrane and Nesprin proteins embedded in the outer membrane. The LINC complex, by interacting with both the nuclear lamina and the cytoskeleton, transmits mechanical forces to the nucleus regulating its morphology and functional homeostasis. In this study we show extensive alterations to the LINC complex in motor and cortical iPSC-derived neurons and spinal cord organoids carrying the ALS causative mutation in the <jats:italic>C9ORF72</jats:italic> gene (C9). Importantly, we show that such alterations are present in vivo in a cohort of sporadic ALS and C9-ALS postmortem spinal cord and motor cortex specimens. We also found that LINC complex disruption strongly correlated with nuclear morphological alterations occurring in ALS neurons, independently of TDP43 mislocalization. Altogether, our data establish morphological and functional alterations to the LINC complex as important events in ALS pathogenic cascade, making this pathway a possible target for both biomarker and therapy development.</jats:p>", "link": "https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01778-z", "published_date": "2024-04-24T23:00:00Z", "source": "BioMedCentral", "publisher": "Springer Science and Business Media LLC", "container_title": "Acta Neuropathologica Communications", "authors": [ { "author_id": 348935, "given_name": "Riccardo", "family_name": "Sirtori", "ORCID": null, "country": null }, { "author_id": 348936, "given_name": "Michelle", "family_name": "J. Gregoire", "ORCID": null, "country": null }, { "author_id": 348937, "given_name": "Emily", "family_name": "M. Potts", "ORCID": null, "country": null }, { "author_id": 348938, "given_name": "Alicia", "family_name": "Collins", "ORCID": null, "country": null }, { "author_id": 348939, "given_name": "Liviana", "family_name": "Donatelli", "ORCID": null, "country": null }, { "author_id": 348940, "given_name": "Claudia", "family_name": "Fallini", "ORCID": "http://orcid.org/0000-0001-8329-3467", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-25T22:27:48.665342Z", "noun_phrases": null, "doi": "10.1186/s40478-024-01778-z", "access": "restricted", "takeaways": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that mainly affects motor neurons. The exact cause of ALS is not fully understood. Emerging research suggests that dysfunction of the nuclear envelope (NE) may contribute to disease pathogenesis and progression. The NE plays a role in ALS through several mechanisms, including nuclear pore defects, nucleocytoplasmic transport impairment, accumulation of mislocalized proteins, and nuclear morphology abnormalities. The LINC complex is", "categories": [] }, { "article_id": 283244, "title": "The revision and factor analytic evaluation of the German version of the depression literacy scale (D-Lit-R German)", "summary": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>Depression is a common mental health disorder and the second leading cause of disability worldwide. In people with depression, low depression literacy, which could be characterized by a poor recognition of depressive symptoms and less knowledge about the availability of treatment options, can hinder adequate therapy for depression. Nevertheless, questionnaires measuring depression literacy in Germany are rare. Consequently, for the present study, the German Depression Literacy Scale (D-Lit) has been revised and evaluated.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>First, a team of clinical psychologists revised the D-Lit German scale. Next, cognitive interviews were conducted with patients with depression to improve the comprehensibility of the scale items. Our revision of the D-Lit-R German scale was then subjected to an anonymous online study. Finally, the data went through an exploratory factor analysis, and sociodemographic subgroup analyses were performed.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p><jats:italic>N</jats:italic> = 524 individuals (age 18–80) completed the D-Lit-R German scale and a questionnaire on their sociodemographic data. Cronbach´s alpha was estimated as α = .72, and McDonald's Omega (categorical) was estimated as ω = .77. The mean Item difficulty was<jats:italic> M</jats:italic> = .75 (<jats:italic>SD</jats:italic> = .15). An EFA was performed for a unidimensional model, a 5-factor-model and at last a 3-factor-model. The 5-factorial model showed a good model fit (χ<jats:sup>2</jats:sup><jats:sub>emp,WLSMV</jats:sub>(131) = 92.424, <jats:italic>p</jats:italic> > .05; CFI = 1, RMSEA = 0, SRMR = .07) but was rejected since the content of the potential 5 factors could not be determined. The 3-factor model showed an arguable model fit. The Chi<jats:sup>2</jats:sup> test was significant (χ<jats:sup>2</jats:sup><jats:sub>emp,WLSMV</jats:sub>(168) = 199.912, <jats:italic>p</jats:italic> < .05), but the CFI and the RMSEA met an acceptable model fit (CFI = .990, RMSEA of .019, 90% CI[.003, .029]). Substantively, the three factors were defined as (1) Distractors and other symptoms, (2) Depressive symptoms, and (3) Pharmacological and psychotherapeutic depression treatment. Furthermore, there were significant differences in sum scores regarding the subgroup's gender, treatment for mental health problems, depression treatment, experience with depression, and different career fields.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>The D-Lit-R German scale is a time-efficient scale to assess some aspects of the depression literacy construct that can be easily applied. Since there was no perfect model fit, it is recommended to continue to revise the scale. Further evaluation studies could ask for knowledge of the etiological factors of depression. Future studies could then use this instrument to convey depression literacy. This instrument could assess the growth of knowledge after psychoeducational interventions in different settings.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Trial registration</jats:title>\n <jats:p>This trial was preregistered at the platform osf.io (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"uri\" xlink:href=\"https://osf.io/49xdh\">https://osf.io/49xdh</jats:ext-link>).</jats:p>\n <jats:p>Registration number: <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"uri\" xlink:href=\"https://doi.org/10.17605/OSF.IO/49XDH\">https://doi.org/10.17605/OSF.IO/49XDH</jats:ext-link></jats:p>\n <jats:p>Date of registration: 28 April 2022.</jats:p>\n </jats:sec>", "link": "https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-024-01730-9", "published_date": "2024-04-24T23:00:00Z", "source": "BioMedCentral", "publisher": "Springer Science and Business Media LLC", "container_title": "BMC Psychology", "authors": [ { "author_id": 348986, "given_name": "Lisa", "family_name": "Hattenkofer", "ORCID": null, "country": null }, { "author_id": 348987, "given_name": "Lukas", "family_name": "Kaupe", "ORCID": null, "country": null }, { "author_id": 348988, "given_name": "Jonas", "family_name": "Raub", "ORCID": null, "country": null }, { "author_id": 348989, "given_name": "Philipp", "family_name": "Reindl-Spanner", "ORCID": null, "country": null }, { "author_id": 348990, "given_name": "Hannah", "family_name": "Schillok", "ORCID": null, "country": null }, { "author_id": 348991, "given_name": "Petra", "family_name": "Schönweger", "ORCID": null, "country": null }, { "author_id": 348992, "given_name": "Clara", "family_name": "Teusen", "ORCID": null, "country": null }, { "author_id": 348993, "given_name": "Marie", "family_name": "Vogel", "ORCID": null, "country": null }, { "author_id": 348994, "given_name": "Victoria", "family_name": "von Schrottenberg", "ORCID": null, "country": null }, { "author_id": 348995, "given_name": "Jochen", "family_name": "Vukas", "ORCID": null, "country": null }, { "author_id": 348996, "given_name": "Puya", "family_name": "Younesi", "ORCID": null, "country": null }, { "author_id": 348967, "given_name": "Feyza", "family_name": "Gökce", "ORCID": null, "country": null }, { "author_id": 348968, "given_name": "Denise", "family_name": "Jais", "ORCID": null, "country": null }, { "author_id": 348969, "given_name": "Philipp", "family_name": "Sterner", "ORCID": null, "country": null }, { "author_id": 252017, "given_name": "Antonius", "family_name": "Schneider", "ORCID": null, "country": null }, { "author_id": 348970, "given_name": "Jochen", "family_name": "Gensichen", "ORCID": null, "country": null }, { "author_id": 348971, "given_name": "Gabriele", "family_name": "Pitschel-Walz", "ORCID": null, "country": null }, { "author_id": 348972, "given_name": "Markus", "family_name": "Bühner", "ORCID": null, "country": null }, { "author_id": 348973, "given_name": "Tobias", "family_name": "Dreischulte", "ORCID": null, "country": null }, { "author_id": 264861, "given_name": "Peter", "family_name": "Falkai", "ORCID": null, "country": null }, { "author_id": 348970, "given_name": "Jochen", "family_name": "Gensichen", "ORCID": null, "country": null }, { "author_id": 310148, "given_name": "Peter", "family_name": "Henningsen", "ORCID": null, "country": null }, { "author_id": 348974, "given_name": "Caroline", "family_name": "Jung-Sievers", "ORCID": null, "country": null }, { "author_id": 348975, "given_name": "Helmut", "family_name": "Krcmar", "ORCID": null, "country": null }, { "author_id": 348976, "given_name": "Kirsten", "family_name": "Lochbühler", "ORCID": null, "country": null }, { "author_id": 348977, "given_name": "Karoline", "family_name": "Lukaschek", "ORCID": null, "country": null }, { "author_id": 348971, "given_name": "Gabriele", "family_name": "Pitschel-Walz", "ORCID": null, "country": null }, { "author_id": 348978, "given_name": "Barbara", "family_name": "Prommegger", "ORCID": null, "country": null }, { "author_id": 348979, "given_name": "Andrea", "family_name": "Schmitt", "ORCID": null, "country": null }, { "author_id": 252017, "given_name": "Antonius", "family_name": "Schneider", "ORCID": null, "country": null }, { "author_id": 348980, "given_name": "Katharina", "family_name": "Biersack", "ORCID": null, "country": null }, { "author_id": 348981, "given_name": "Constantin", "family_name": "Brand", "ORCID": null, "country": null }, { "author_id": 348982, "given_name": "Vita", "family_name": "Brisnik", "ORCID": null, "country": null }, { "author_id": 348983, "given_name": "Christopher", "family_name": "Ebert", "ORCID": null, "country": null }, { "author_id": 348984, "given_name": "Julia", "family_name": "Eder", "ORCID": null, "country": null }, { "author_id": 348967, "given_name": "Feyza", "family_name": "Gökce", "ORCID": null, "country": null }, { "author_id": 348985, "given_name": "Carolin", "family_name": "Haas", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-25T20:27:08.401545Z", "noun_phrases": null, "doi": "10.1186/s40359-024-01730-9", "access": "restricted", "takeaways": null, "categories": [] }, { "article_id": 283243, "title": "Chronic meningitis in adults: a comparison between neurotuberculosis and neurobrucellosis", "summary": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>In regions endemic for tuberculosis and brucellosis, distinguishing between tuberculous meningitis (TBM) and brucella meningitis (BM) poses a substantial challenge. This study investigates the clinical and paraclinical characteristics of patients with TBM and BM.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>Adult patients diagnosed with either TBM or BM who were admitted to two referral hospitals between March 2015 and October 2022, were included, and the characteristics of the patients were analyzed.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>Seventy patients formed the study group, 28 with TBM and 42 with BM, were included. TBM patients had a 2.06-fold (95% CI: 1.26 to 3.37, <jats:italic>P</jats:italic>-value: 0.003) higher risk of altered consciousness and a 4.80-fold (95% CI: 1.98 to 11.61, <jats:italic>P</jats:italic>-value: < 0.001) higher risk of extra-neural involvement as compared to BM patients. Cerebrospinal fluid (CSF) analysis revealed a significantly higher percentage of polymorphonuclear leukocytes (PMN) in TBM compared to BM (Standardized mean difference: 0.69, 95% CI: 0.18 to 1.20, <jats:italic>P</jats:italic>-value: 0.008). Neuroimaging findings indicated higher risks of hydrocephalus (<jats:italic>P</jats:italic>-value: 0.002), infarction (<jats:italic>P</jats:italic>-value: 0.029), and meningeal enhancement (<jats:italic>P</jats:italic>-value: 0.012) in TBM compared to BM. Moreover, TBM patients had a 67% (95% CI: 21% to 131%, <jats:italic>P</jats:italic>-value:0.002) longer median length of hospital stay and a significantly higher risk of unfavorable outcomes (Risk ratio: 6.96, 95% CI: 2.65 to 18.26, <jats:italic>p</jats:italic> < 0.001).</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>Our study emphasizes that TBM patients displayed increased frequencies of altered consciousness, PMN dominance in CSF, extra-neural involvement, hydrocephalus, meningeal enhancement, and brain infarction. The findings emphasize the diagnostic difficulties and underscore the importance of cautious differentiation between these two conditions to guide appropriate treatment strategies.</jats:p>\n </jats:sec>", "link": "https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09345-6", "published_date": "2024-04-24T23:00:00Z", "source": "BioMedCentral", "publisher": "Springer Science and Business Media LLC", "container_title": "BMC Infectious Diseases", "authors": [ { "author_id": 348929, "given_name": "Matin", "family_name": "Shirazinia", "ORCID": null, "country": null }, { "author_id": 348930, "given_name": "Fereshte", "family_name": "Sheybani", "ORCID": "http://orcid.org/0000-0002-0766-4286", "country": null }, { "author_id": 348931, "given_name": "HamidReza", "family_name": "Naderi", "ORCID": null, "country": null }, { "author_id": 348932, "given_name": "Mahboubeh", "family_name": "Haddad", "ORCID": null, "country": null }, { "author_id": 348933, "given_name": "Pouria", "family_name": "Hajipour", "ORCID": null, "country": null }, { "author_id": 348934, "given_name": "Farzaneh", "family_name": "Khoroushi", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-25T20:26:58.395564Z", "noun_phrases": null, "doi": "10.1186/s12879-024-09345-6", "access": "restricted", "takeaways": "Tuberculous meningitis (TBM) and brucella meningitis (BM) are difficult to distinguish between. TBM patients have a higher risk of altered consciousness, extra-neural involvement, hydrocephalus, meningeal enhancement, and brain infarction. BM patients also have a 67% longer median length of hospital stay.", "categories": [] }, { "article_id": 283241, "title": "Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response", "summary": "<jats:title>Abstract</jats:title><jats:p>Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnings of resilience remain poorly understood. To obtain an unbiased understanding of the molecular changes underlying resilience, we investigated global changes in gene expression in the superior frontal gyrus of a cohort of cognitively and pathologically well-defined AD patients, resilient individuals and age-matched controls (n = 11–12 per group). 897 genes were significantly altered between AD and control, 1121 between resilient and control and 6 between resilient and AD. Gene set enrichment analysis (GSEA) revealed that the expression of metallothionein (MT) and of genes related to mitochondrial processes was higher in the resilient donors. Weighted gene co-expression network analysis (WGCNA) identified gene modules related to the unfolded protein response, mitochondrial processes and synaptic signaling to be differentially associated with resilience or dementia. As changes in MT, mitochondria, heat shock proteins and the unfolded protein response (UPR) were the most pronounced changes in the GSEA and/or WGCNA, immunohistochemistry was used to further validate these processes. MT was significantly increased in astrocytes in resilient individuals. A higher proportion of the mitochondrial gene MT-CO1 was detected outside the cell body versus inside the cell body in the resilient compared to the control group and there were higher levels of heat shock protein 70 (HSP70) and X-box-binding protein 1 spliced (XBP1s), two proteins related to heat shock proteins and the UPR, in the AD donors. Finally, we show evidence for putative sex-specific alterations in resilience, including gene expression differences related to autophagy in females compared to males. Taken together, these results show possible mechanisms involving MTs, mitochondrial processes and the UPR by which individuals might maintain cognition despite the presence of AD pathology.</jats:p>", "link": "https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01760-9", "published_date": "2024-04-24T23:00:00Z", "source": "BioMedCentral", "publisher": "Springer Science and Business Media LLC", "container_title": "Acta Neuropathologica Communications", "authors": [ { "author_id": 347543, "given_name": "Luuk E.", "family_name": "de Vries", "ORCID": "http://orcid.org/0009-0005-6133-1043", "country": null }, { "author_id": 348999, "given_name": "Aldo", "family_name": "Jongejan", "ORCID": "http://orcid.org/0000-0002-8948-2549", "country": null }, { "author_id": 349000, "given_name": "Jennifer", "family_name": "Monteiro Fortes", "ORCID": null, "country": null }, { "author_id": 349001, "given_name": "Rawien", "family_name": "Balesar", "ORCID": null, "country": null }, { "author_id": 349002, "given_name": "Annemieke J. M.", "family_name": "Rozemuller", "ORCID": "http://orcid.org/0000-0003-2528-4428", "country": null }, { "author_id": 349003, "given_name": "Perry D.", "family_name": "Moerland", "ORCID": "http://orcid.org/0000-0002-2357-3659", "country": "NL" }, { "author_id": 174751, "given_name": "Inge", "family_name": "Huitinga", "ORCID": "http://orcid.org/0000-0002-4878-8920", "country": null }, { "author_id": 347545, "given_name": "Dick F.", "family_name": "Swaab", "ORCID": "http://orcid.org/0000-0002-9665-7845", "country": null }, { "author_id": 347546, "given_name": "Joost", "family_name": "Verhaagen", "ORCID": "http://orcid.org/0000-0002-8341-1096", "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2024-04-25T16:27:28.454507Z", "noun_phrases": null, "doi": "10.1186/s40478-024-01760-9", "access": "restricted", "takeaways": "There is a discrepancy between cognition and neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’ The molecular and cellular underpinnings of resilience remain poorly understood. We investigated global changes in gene expression in the superior frontal gyrus of a cohort of AD patients, resilient individuals and age-matched controls. 897 genes were significantly altered between AD and control.", "categories": [] } ] }