List all articles in the database by earliest discovery_date

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    "count": 23920,
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    "results": [
        {
            "article_id": 282436,
            "title": "Emergency department visits by nursing home residents. A retrospective Italian study of administrative databases from 2015 to 2019",
            "summary": null,
            "link": "https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-024-04912-7",
            "published_date": "2024-03-28T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": null,
            "container_title": null,
            "authors": [],
            "relevant": null,
            "ml_prediction_gnb": null,
            "ml_prediction_lr": null,
            "ml_prediction_lsvc": null,
            "discovery_date": "2024-03-28T10:42:35.351849Z",
            "noun_phrases": null,
            "doi": "10.1186/s12877-024-04912-7",
            "access": "restricted",
            "takeaways": null,
            "categories": []
        },
        {
            "article_id": 282434,
            "title": "A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors",
            "summary": null,
            "link": "https://alzres.biomedcentral.com/articles/10.1186/s13195-024-01420-z",
            "published_date": "2024-03-28T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": null,
            "container_title": null,
            "authors": [],
            "relevant": null,
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            "discovery_date": "2024-03-28T08:42:45.237277Z",
            "noun_phrases": null,
            "doi": "10.1186/s13195-024-01420-z",
            "access": "restricted",
            "takeaways": null,
            "categories": []
        },
        {
            "article_id": 282433,
            "title": "Delays in Multiple Sclerosis diagnosis (DIMES): protocol for a multicentre, observational study of multiple sclerosis diagnostic pathways in the United Kingdom and Republic of Ireland",
            "summary": null,
            "link": "https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-024-03598-z",
            "published_date": "2024-03-28T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": null,
            "container_title": null,
            "authors": [],
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            "ml_prediction_gnb": null,
            "ml_prediction_lr": null,
            "ml_prediction_lsvc": null,
            "discovery_date": "2024-03-28T06:42:35.229967Z",
            "noun_phrases": null,
            "doi": "10.1186/s12883-024-03598-z",
            "access": "restricted",
            "takeaways": null,
            "categories": []
        },
        {
            "article_id": 282429,
            "title": "Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories",
            "summary": "One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical manifestations and progression trajectories. It still remains to be elucidated whether this heterogeneity is reflected by discrete immune signatures in the blood as a surrogate of disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles is still not feasible. Using two independent multicentric longitudinal cohorts of patients with early multiple sclerosis (n = 309 discovery and n = 232 validation), we were able to identify three distinct peripheral blood immunological endophenotypes by a combination of high-dimensional flow cytometry and serum proteomics, followed by unsupervised clustering. Longitudinal clinical and paraclinical follow-up data collected for the cohorts revealed that these endophenotypes were associated with disease trajectories of inflammation versus early structural damage. Investigating the capacity of immunotherapies to normalize endophenotype-specific immune signatures revealed discrete effect sizes as illustrated by the limited effect of interferon-β on endophenotype 3–related immune signatures. Accordingly, patients who fell into endophenotype 3 subsequently treated with interferon-β exhibited higher disease progression and MRI activity over a 4-year follow-up compared with treatment with other therapies. We therefore propose that ascertaining a patient’s blood immune signature before immunomodulatory treatment initiation may facilitate prediction of clinical disease trajectories and enable personalized treatment decisions based on pathobiological principles.",
            "link": "https://www.science.org/doi/10.1126/scitranslmed.ade8560#con40",
            "published_date": "2024-03-27T00:00:00Z",
            "source": "Manual Input",
            "publisher": "American Association for the Advancement of Science (AAAS)",
            "container_title": "Science Translational Medicine",
            "authors": [
                {
                    "author_id": 180548,
                    "given_name": "Catharina C.",
                    "family_name": "Gross",
                    "ORCID": "http://orcid.org/0000-0002-4872-9189",
                    "country": null
                },
                {
                    "author_id": 172216,
                    "given_name": "Andreas",
                    "family_name": "Schulte-Mecklenbeck",
                    "ORCID": "http://orcid.org/0000-0003-3855-4706",
                    "country": null
                },
                {
                    "author_id": 346457,
                    "given_name": "Olga V.",
                    "family_name": "Steinberg",
                    "ORCID": "http://orcid.org/0009-0000-7370-6811",
                    "country": null
                },
                {
                    "author_id": 346458,
                    "given_name": "Timo",
                    "family_name": "Wirth",
                    "ORCID": "http://orcid.org/0000-0002-0102-4608",
                    "country": "DE"
                },
                {
                    "author_id": 346459,
                    "given_name": "Sarah",
                    "family_name": "Lauks",
                    "ORCID": "http://orcid.org/0009-0008-4151-0003",
                    "country": null
                },
                {
                    "author_id": 154545,
                    "given_name": "Stefan",
                    "family_name": "Bittner",
                    "ORCID": "http://orcid.org/0000-0003-2179-3655",
                    "country": null
                },
                {
                    "author_id": 188773,
                    "given_name": "Patrick",
                    "family_name": "Schindler",
                    "ORCID": "http://orcid.org/0000-0002-8846-121X",
                    "country": null
                },
                {
                    "author_id": 155940,
                    "given_name": "Sergio E.",
                    "family_name": "Baranzini",
                    "ORCID": "http://orcid.org/0000-0003-0067-194X",
                    "country": "US"
                },
                {
                    "author_id": 162592,
                    "given_name": "Sergiu",
                    "family_name": "Groppa",
                    "ORCID": "http://orcid.org/0000-0002-2551-5655",
                    "country": "DE"
                },
                {
                    "author_id": 143302,
                    "given_name": "Judith",
                    "family_name": "Bellmann-Strobl",
                    "ORCID": "http://orcid.org/0000-0003-2615-1643",
                    "country": null
                },
                {
                    "author_id": 346460,
                    "given_name": "Nora",
                    "family_name": "Bünger",
                    "ORCID": "http://orcid.org/0009-0000-3821-5187",
                    "country": null
                },
                {
                    "author_id": 143294,
                    "given_name": "Claudia",
                    "family_name": "Chien",
                    "ORCID": "http://orcid.org/0000-0001-8280-9513",
                    "country": null
                },
                {
                    "author_id": 346461,
                    "given_name": "Eva",
                    "family_name": "Dawin",
                    "ORCID": "http://orcid.org/0000-0002-4755-1534",
                    "country": null
                },
                {
                    "author_id": 346462,
                    "given_name": "Maria",
                    "family_name": "Eveslage",
                    "ORCID": "http://orcid.org/0000-0002-8802-1134",
                    "country": null
                },
                {
                    "author_id": 198016,
                    "given_name": "Vinzenz",
                    "family_name": "Fleischer",
                    "ORCID": "http://orcid.org/0000-0002-3293-5121",
                    "country": null
                },
                {
                    "author_id": 186068,
                    "given_name": "Gabriel",
                    "family_name": "Gonzalez-Escamilla",
                    "ORCID": "http://orcid.org/0000-0002-7209-1736",
                    "country": null
                },
                {
                    "author_id": 221280,
                    "given_name": "Barbara",
                    "family_name": "Gisevius",
                    "ORCID": "http://orcid.org/0000-0002-6018-4441",
                    "country": null
                },
                {
                    "author_id": 346463,
                    "given_name": "Jürgen",
                    "family_name": "Haas",
                    "ORCID": "http://orcid.org/0000-0002-2314-7465",
                    "country": null
                },
                {
                    "author_id": 175284,
                    "given_name": "Martin",
                    "family_name": "Kerschensteiner",
                    "ORCID": "http://orcid.org/0000-0003-4898-9383",
                    "country": null
                },
                {
                    "author_id": 346464,
                    "given_name": "Lucienne",
                    "family_name": "Kirstein",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 244246,
                    "given_name": "Catharina",
                    "family_name": "Korsukewitz",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 159860,
                    "given_name": "Lisa",
                    "family_name": "Lohmann",
                    "ORCID": "http://orcid.org/0000-0003-4911-6883",
                    "country": null
                },
                {
                    "author_id": 169276,
                    "given_name": "Jan D.",
                    "family_name": "Lünemann",
                    "ORCID": "http://orcid.org/0000-0002-3007-708X",
                    "country": null
                },
                {
                    "author_id": 154547,
                    "given_name": "Felix",
                    "family_name": "Luessi",
                    "ORCID": "http://orcid.org/0000-0003-4334-4199",
                    "country": null
                },
                {
                    "author_id": 160220,
                    "given_name": "Gerd",
                    "family_name": "Meyer zu Hörste",
                    "ORCID": "http://orcid.org/0000-0002-4341-4719",
                    "country": "DE"
                },
                {
                    "author_id": 221282,
                    "given_name": "Jeremias",
                    "family_name": "Motte",
                    "ORCID": "http://orcid.org/0000-0002-6624-8565",
                    "country": null
                },
                {
                    "author_id": 172220,
                    "given_name": "Tobias",
                    "family_name": "Ruck",
                    "ORCID": "http://orcid.org/0000-0001-6332-8650",
                    "country": null
                },
                {
                    "author_id": 156906,
                    "given_name": "Klemens",
                    "family_name": "Ruprecht",
                    "ORCID": "http://orcid.org/0000-0003-1962-6014",
                    "country": null
                },
                {
                    "author_id": 172226,
                    "given_name": "Nicholas",
                    "family_name": "Schwab",
                    "ORCID": "http://orcid.org/0000-0001-5494-9885",
                    "country": "DE"
                },
                {
                    "author_id": 170490,
                    "given_name": "Falk",
                    "family_name": "Steffen",
                    "ORCID": "http://orcid.org/0000-0003-3708-8600",
                    "country": null
                },
                {
                    "author_id": 155182,
                    "given_name": "Sven G.",
                    "family_name": "Meuth",
                    "ORCID": "http://orcid.org/0000-0003-2571-3501",
                    "country": "DE"
                },
                {
                    "author_id": 148866,
                    "given_name": "Friedemann",
                    "family_name": "Paul",
                    "ORCID": "http://orcid.org/0000-0002-6378-0070",
                    "country": null
                },
                {
                    "author_id": 240370,
                    "given_name": "Brigitte",
                    "family_name": "Wildemann",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 199738,
                    "given_name": "Tania",
                    "family_name": "Kümpfel",
                    "ORCID": "http://orcid.org/0000-0001-7509-5268",
                    "country": null
                },
                {
                    "author_id": 147050,
                    "given_name": "Ralf",
                    "family_name": "Gold",
                    "ORCID": "http://orcid.org/0000-0002-7223-3052",
                    "country": null
                },
                {
                    "author_id": 199488,
                    "given_name": "Tim",
                    "family_name": "Hahn",
                    "ORCID": "http://orcid.org/0000-0001-6541-3795",
                    "country": null
                },
                {
                    "author_id": 161633,
                    "given_name": "Frauke",
                    "family_name": "Zipp",
                    "ORCID": "http://orcid.org/0000-0002-1231-1928",
                    "country": null
                },
                {
                    "author_id": 185561,
                    "given_name": "Luisa",
                    "family_name": "Klotz",
                    "ORCID": "http://orcid.org/0000-0001-5439-9633",
                    "country": null
                },
                {
                    "author_id": 160394,
                    "given_name": "Heinz",
                    "family_name": "Wiendl",
                    "ORCID": "http://orcid.org/0000-0003-4310-3432",
                    "country": null
                },
                {
                    "author_id": 240871,
                    "given_name": "Ilya",
                    "family_name": "Ayzenberg",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 203076,
                    "given_name": "Antonios",
                    "family_name": "Bayas",
                    "ORCID": "http://orcid.org/0000-0002-7418-9040",
                    "country": null
                },
                {
                    "author_id": 257650,
                    "given_name": "Klaus",
                    "family_name": "Berger",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 162718,
                    "given_name": "Wolfgang",
                    "family_name": "Brück",
                    "ORCID": "http://orcid.org/0000-0002-6881-4479",
                    "country": null
                },
                {
                    "author_id": 346465,
                    "given_name": "Sina",
                    "family_name": "Engel",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 265297,
                    "given_name": "Boris",
                    "family_name": "Kallmann",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 321830,
                    "given_name": "Markus",
                    "family_name": "Kowarik",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 241413,
                    "given_name": "Ralf",
                    "family_name": "Linker",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 219263,
                    "given_name": "Carsten",
                    "family_name": "Lukas",
                    "ORCID": "http://orcid.org/0000-0002-8562-9697",
                    "country": null
                },
                {
                    "author_id": 256330,
                    "given_name": "Mathias",
                    "family_name": "Mäurer",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 324554,
                    "given_name": "Sandra",
                    "family_name": "Nischwitz",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 151304,
                    "given_name": "Anke",
                    "family_name": "Salmen",
                    "ORCID": "http://orcid.org/0000-0002-4751-299X",
                    "country": null
                },
                {
                    "author_id": 346466,
                    "given_name": "Edda",
                    "family_name": "Sauer",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309281,
                    "given_name": "Christine",
                    "family_name": "Stadelmann-Nessler",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 247640,
                    "given_name": "Florian",
                    "family_name": "Then Bergh",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 246834,
                    "given_name": "Corinna",
                    "family_name": "Trebst",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 184051,
                    "given_name": "Clemens",
                    "family_name": "Warnke",
                    "ORCID": "http://orcid.org/0000-0002-3510-9255",
                    "country": null
                }
            ],
            "relevant": true,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2024-03-27T20:45:58.025986Z",
            "noun_phrases": null,
            "doi": "https://doi.org/10.1126/scitranslmed.ade8560",
            "access": "unknown",
            "takeaways": "",
            "categories": []
        },
        {
            "article_id": 282427,
            "title": "Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases",
            "summary": "<jats:title>Abstract</jats:title><jats:p>Recent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rather than the tau pathology. However, confirmation using gold standard neuropathological assessments remains limited. This study aimed to determine background pathologies associated with aberrant CSF p-tau181 and amyloid-beta 1–42 (Aβ42) in Alzheimer’s disease (AD) and other neurodegenerative diseases. We retrospectively studied all patients with antemortem CSF and postmortem neuropathologic data at our institution. Comprehensive neuropathologic assessments were conducted for all patients, including Thal phase, Braak NFT stage, and CERAD score for AD. CSF concentrations of p-tau181 and Aβ42 were compared between AD neuropathological scores at autopsy by one-way ANOVA stratified by other pathologies. A total of 127 patients with AD (<jats:italic>n</jats:italic> = 22), Lewy body disease (<jats:italic>n</jats:italic> = 26), primary tauopathies (<jats:italic>n</jats:italic> = 30), TDP-43 proteinopathy (<jats:italic>n</jats:italic> = 16), and other diseases (<jats:italic>n</jats:italic> = 33) were included. The age at lumbar puncture was 76.3 ± 9.1 years, 40.8% were female, and median time from lumbar puncture to autopsy was 637 (175–1625) days. While Braak NFT 0–II was prevalent without amyloid pathology, Braak NFT ≥IV was observed exclusively in patients with amyloid pathology. Stratified analyses showed that CSF p-tau181 was slightly but significantly higher in patients with high Thal phase or CERAD score even in those with Braak NFT 0–II at autopsy. In patients with amyloid pathology, CSF p-tau181 was significantly and more profoundly elevated in those with Braak NFT ≥III at autopsy. CSF Aβ42 was lower in patients with high amyloid pathological scores. However, 34% with Thal ≤ 2 and 38% with CERAD ≤ sparse also showed decreased Aβ42. Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) were overrepresented in this group. These results neuropathologically confirmed previous studies that CSF p-tau181 levels were slightly elevated with amyloid pathology alone and were even higher with tau pathology, and that CSFAβ42 can be decreased in PSP/CBD.</jats:p>",
            "link": "https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01758-3",
            "published_date": "2024-03-27T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Acta Neuropathologica Communications",
            "authors": [
                {
                    "author_id": 346436,
                    "given_name": "Masanori",
                    "family_name": "Kurihara",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346437,
                    "given_name": "Tomoyasu",
                    "family_name": "Matsubara",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 283143,
                    "given_name": "Satoru",
                    "family_name": "Morimoto",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346438,
                    "given_name": "Akira",
                    "family_name": "Arakawa",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346439,
                    "given_name": "Kensuke",
                    "family_name": "Ohse",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346440,
                    "given_name": "Kazutomi",
                    "family_name": "Kanemaru",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 325098,
                    "given_name": "Atsushi",
                    "family_name": "Iwata",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 268059,
                    "given_name": "Shigeo",
                    "family_name": "Murayama",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 249462,
                    "given_name": "Yuko",
                    "family_name": "Saito",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": false,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2024-03-27T18:43:25.249202Z",
            "noun_phrases": null,
            "doi": "10.1186/s40478-024-01758-3",
            "access": "restricted",
            "takeaways": "CSF phospho-tau is associated with brain amyloid pathology rather than the tau pathology. 127 patients with AD, Lewy body disease, primary tauopathies, TDP-43 proteinopathy, and other diseases were included in the study. CSF Aβ42 was lower in patients with high amyloids pathological scores. ",
            "categories": []
        },
        {
            "article_id": 282425,
            "title": "Needs assessment for direct ophthalmoscopy training in neurology residency",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Assessment of the ocular fundus, traditionally by direct ophthalmoscopy (DO), is essential to evaluate many neurologic diseases. However, the status of DO training in neurology residencies is unknown. We conducted a needs assessment to determine current attitudes, curricula, and gaps in DO training.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>A survey was developed and administered to residents and program directors (PDs) at ACGME accredited neurology residencies in the United States. The survey assessed factors such as current DO curricula, perceived importance of DO, confidence of skills, and need for improvement. Data analysis was performed using the Mann Whitney U test and Fisher Exact Test.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>Nineteen PDs (11.6%) and 74 (41.1%) residents responded to the survey. 97.1% of residents and 100.0% of PDs believe DO is an important skill to learn. 29.4% of PDs expected graduating residents to have completed &gt; 10 supervised DO exams, while 0.0% of graduating fourth year residents reported doing so (<jats:italic>p</jats:italic> = 0.03). 35.7% of graduating residents had never correctly identified an abnormal finding on DO. The number of times residents practiced DO unsupervised correlated with increasing confidence in all components of the DO exam (<jats:italic>p</jats:italic> &lt; 0.05). Residents who felt their program emphasized DO were more likely to perform DO at least once a week compared to residents who did not perceive program emphasis (61.9% vs. 35.0%, <jats:italic>p</jats:italic> = 0.02) and were more confident in DO (<jats:italic>p</jats:italic> &lt; 0.05). 66.7% of residents and 42.1% of PDs were not satisfied with current levels of DO training. 96.7% of residents and 78.9% of PDs felt it was important to improve curriculum for DO training. Supervised practice and practice skills sessions were identified as the most helpful interventions to improve DO training.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusions</jats:title>\n                <jats:p>The vast majority of neurology PDs and residents believe DO is an important skill to learn, are unsatisfied with the current level of DO training, and advocate for improvement in DO curricula. Current DO curricula have limited formal didactic training and supervised practice. The bulk of DO learning occurs through unsupervised practice, which is influenced by motivational factors such as perceived residency emphasis on DO learning.</jats:p>\n              </jats:sec>",
            "link": "https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-024-05280-x",
            "published_date": "2024-03-27T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "BMC Medical Education",
            "authors": [
                {
                    "author_id": 346449,
                    "given_name": "Jasmeet",
                    "family_name": "Saroya",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346450,
                    "given_name": "Noor",
                    "family_name": "Chahal",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346451,
                    "given_name": "Alice",
                    "family_name": "Jiang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346452,
                    "given_name": "Douglas",
                    "family_name": "Pet",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346453,
                    "given_name": "Nailyn",
                    "family_name": "Rasool",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346454,
                    "given_name": "Mark",
                    "family_name": "Terrelonge",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346455,
                    "given_name": "Madeline",
                    "family_name": "Yung",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2024-03-27T12:42:35.241575Z",
            "noun_phrases": null,
            "doi": "10.1186/s12909-024-05280-x",
            "access": "restricted",
            "takeaways": "In ACGME accredited neurology residencies in the United States, 97.1% of residents and 100.0% of PDs believe that direct ophthalmoscopy (DO) is an important skill to learn. Residents who felt their program emphasized DO were more likely to perform DO at least once a week and to be more confident in the DO exam.",
            "categories": []
        },
        {
            "article_id": 282422,
            "title": "Osteofibrous dysplasia: a narrative review",
            "summary": "<jats:title>Abstract</jats:title><jats:p>Osteofibrous dysplasia (OFD) is a rare, benign, self-limited bone disorder with a relatively low incidence, accounting for approximately 0.2% of all primary bone tumors. It was frequently found intra-cortical of the mid-shaft of the tibia. OFD can also occur in other skeletal regions, including the fibula, ulna, radius, femur, humerus, ischium, rib, tarsus, metatarsals, vertebral, and capitate. OFD can present with asymptomatic, mass, pain, swelling, deformity, and even pathological fracture. OFD might be misdiagnosed as adamantinoma (AD) and because they are three subtypes origin from the same family of bone tumors and have similar imaging features. Moreover, pathology could provide evidence for an accurate diagnosis of OFD, but misdiagnosis may occur due to small sampling materials. To date, few studies have comprehensively introduced the epidemiology, clinical manifestations, pathogenesis, radiological features, pathology, and treatment for OFD. We herein discuss clinical signs, diagnosis methods, and treatment options of OFD to improve the understanding of OFD, which is helpful for accurate diagnosis and appropriate treatment.</jats:p>",
            "link": "https://josr-online.biomedcentral.com/articles/10.1186/s13018-024-04682-3",
            "published_date": "2024-03-27T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Orthopaedic Surgery and Research",
            "authors": [
                {
                    "author_id": 286464,
                    "given_name": "Rui",
                    "family_name": "Liu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346443,
                    "given_name": "Linjian",
                    "family_name": "Tong",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346444,
                    "given_name": "Haiyang",
                    "family_name": "Wu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346445,
                    "given_name": "Qiang",
                    "family_name": "Guo",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346446,
                    "given_name": "Lixia",
                    "family_name": "Xu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346447,
                    "given_name": "Zhiming",
                    "family_name": "Sun",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346448,
                    "given_name": "Hua",
                    "family_name": "Yan",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2024-03-27T11:02:53.429325Z",
            "noun_phrases": null,
            "doi": "10.1186/s13018-024-04682-3",
            "access": "restricted",
            "takeaways": "Osteofibrous dysplasia (OFD) is a rare, benign, self-limited bone disorder with a relatively low incidence. OFD can present with asymptomatic, mass, pain, swelling, deformity, and even pathological fracture. Few studies have comprehensively introduced the epidemiology, clinical manifestations, pathogenesis, radiological features, pathology, and",
            "categories": []
        },
        {
            "article_id": 282421,
            "title": "Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit",
            "summary": "<jats:title>Abstract</jats:title><jats:p>Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. PD symptoms develop due to the disruption of dopaminergic neurotransmitters and other neurotransmitters such as γ-aminobutyric acid (GABA). The potential role of GABA in PD neuropathology concerning the motor and non-motor symptoms of PD was not precisely discussed. Therefore, this review intended to illustrate the possible role of GABA in PD neuropathology regarding motor and non-motor symptoms. The GABA pathway is essential in regulating the inhibitory tone to prevent excessive stimulation of the cerebral cortex. Degeneration of dopaminergic neurons in PD is linked with reducing GABAergic neurotransmission. Decreasing GABA activity promotes mitochondrial dysfunction and oxidative stress, which are highly related to PD neuropathology. Hence, restoring GABA activity by GABA agonists may attenuate the progression of PD motor symptoms. Therefore, dysregulation of GABAergic neurons in the SNpc contributes to developing PD motor symptoms. Besides, PD non-motor symptoms are also related to the dysfunction of the GABAergic pathway, and amelioration of this pathway may reduce PD non-motor symptoms. In conclusion, the deregulation of the GABAergic pathway in PD might be intricate in developing motor and non-motor symptoms. Improving this pathway might be a novel, beneficial approach to control PD symptoms.</jats:p>",
            "link": "https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-024-01779-7",
            "published_date": "2024-03-27T00:00:00Z",
            "source": "BioMedCentral",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "European Journal of Medical Research",
            "authors": [
                {
                    "author_id": 318111,
                    "given_name": "Marios",
                    "family_name": "Papadakis",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 256442,
                    "given_name": "Gaber El-Saber",
                    "family_name": "Batiha",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346441,
                    "given_name": "Bandar",
                    "family_name": "Alharbi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 324242,
                    "given_name": "Hayder M.",
                    "family_name": "Al-kuraishy",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 318107,
                    "given_name": "Ali I.",
                    "family_name": "Al-Gareeb",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 343791,
                    "given_name": "Engy",
                    "family_name": "Elekhnawy",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346442,
                    "given_name": "Hind",
                    "family_name": "Alharbi",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2024-03-27T11:02:43.448868Z",
            "noun_phrases": null,
            "doi": "10.1186/s40001-024-01779-7",
            "access": "restricted",
            "takeaways": "Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. The GABA pathway is essential in regulating the inhibitory tone to prevent excessive stimulation of the cerebral cortex. Decreasing GABA activity promotes mitochondrial dysfunction and oxidative stress.",
            "categories": []
        },
        {
            "article_id": 282420,
            "title": "Unveiling the Intricacies: A Comprehensive Review of Magnetic Resonance Imaging (MRI) Assessment of T2-Weighted Hyperintensities in the Neuroimaging Landscape",
            "summary": "T2-weighted hyperintensities in neuroimaging represent areas of heightened signal intensity on magnetic resonance imaging (MRI) scans, holding crucial importance in neuroimaging. This comprehensive review explores the T2-weighted hyperintensities, providing insights into their definition, characteristics, clinical relevance, and underlying causes. It highlights the significance of these hyperintensities as sensitive markers for neurological disorders, including multiple sclerosis, vascular...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38529430/?fc=20210216052009&ff=20240327065651&v=2.18.0.post9+e462414",
            "published_date": "2024-03-26T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Cureus",
            "authors": [
                {
                    "author_id": 346430,
                    "given_name": "Rishabh",
                    "family_name": "Dhabalia",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346431,
                    "given_name": "Shivali V",
                    "family_name": "Kashikar",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346432,
                    "given_name": "Pratap S",
                    "family_name": "Parihar",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346433,
                    "given_name": "Gaurav V",
                    "family_name": "Mishra",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2024-03-27T10:57:58.521706Z",
            "noun_phrases": null,
            "doi": "10.7759/cureus.54808",
            "access": "open",
            "takeaways": "T2-weighted hyperintensities in neuroimaging represent areas of heightened signal intensity on MRI scans.",
            "categories": []
        },
        {
            "article_id": 282419,
            "title": "HB-EGF and EGF infusion following CNS demyelination mitigates age-related decline in regeneration of oligodendrocytes from neural precursor cells originating in the ventricular-subventricular zone",
            "summary": "<jats:title>Abstract</jats:title><jats:p>In multiple sclerosis (MS), chronic demyelination initiated by immune-mediated destruction of myelin, leads to axonal damage and neuronal cell death, resulting in a progressive decline in neurological function. The development of interventions that potentiate remyelination could hold promise as a novel treatment strategy for MS. To this end, our group has demonstrated that neural precursor cells (NPCs) residing in the ventricular-subventricular zone (V-SVZ) of the adult mouse brain contribute significantly to remyelination in response to central nervous system (CNS) demyelination and can regenerate myelin of normal thickness. However, aging takes its toll on the regenerative potential of NPCs and reduces their contribution to remyelination. In this study, we investigated how aging influences the contribution of NPCs to oligodendrogenesis during the remyelination process and whether the delivery of growth factors into the brains of aged mice could potentiate the oligodendrogenic potential of NPCs. To enable us to map the fate of NPCs in response to demyelination induced at different postnatal ages,<jats:italic>Nestin-CreER<jats:sup>T2</jats:sup></jats:italic>;<jats:italic>Rosa26-LSL-eYFP</jats:italic>mice were gavaged with tamoxifen at either 8 weeks, 30 weeks or one year of age before being challenged with cuprizone for a period of six weeks. Using osmotic minipumps, we infused heparin-binding EGF-like growth factor (HB-EGF), and/or epidermal growth factor (EGF) into the cisterna magna for a period of two weeks beginning at the peak of cuprizone-induced demyelination (n=6-8 mice per group). Control mice received artificial cerebrospinal fluid (vehicle) alone. Mice were perfused six weeks after cuprizone withdrawal and the contribution of NPCs to oligodendrocyte regeneration in the corpus callosum was assessed. Our data reveal that although NPC-derived oligodendrocyte generation declined dramatically with age, this decline was partially reversed by growth factor infusion. Notably, co-infusion of EGF and HB-EGF increased oligodendrocyte regeneration twofold in some regions of the corpus callosum. Our results shed light on the beneficial effects of EGF and HB-EGF for increasing the contribution of NPCs to remyelination and indicate their therapeutic potential to combat the negative effects of aging upon remyelination efficacy.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/38529498/?fc=20210216052009&ff=20240327065651&v=2.18.0.post9+e462414",
            "published_date": "2024-03-26T10:00:00Z",
            "source": "PubMed",
            "publisher": "Cold Spring Harbor Laboratory",
            "container_title": "",
            "authors": [
                {
                    "author_id": 346426,
                    "given_name": "Kaveh",
                    "family_name": "Moradi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346427,
                    "given_name": "Stanislaw",
                    "family_name": "Mitew",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 346428,
                    "given_name": "Yao Lulu",
                    "family_name": "Xing",
                    "ORCID": "http://orcid.org/0000-0002-5564-4589",
                    "country": "US"
                },
                {
                    "author_id": 346429,
                    "given_name": "Tobias D.",
                    "family_name": "Merson",
                    "ORCID": "http://orcid.org/0000-0002-7246-3608",
                    "country": "US"
                }
            ],
            "relevant": true,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": true,
            "ml_prediction_lsvc": true,
            "discovery_date": "2024-03-27T10:57:54.202941Z",
            "noun_phrases": null,
            "doi": "10.1101/2024.02.26.582092",
            "access": "open",
            "takeaways": "In MS, chronic demyelination is initiated by immune-mediated destruction of myelin. Neuronal precursor cells (NPCs) residing in the ventricular-subventricular zone (V-SVZ) of the adult mouse brain can regenerate myelin of normal thickness. Aging takes its toll on the regenerative potential of NPCs. Infusion of EGF and HB-EGF increased oligodendrocyte regeneration in some regions of the corpus call",
            "categories": []
        }
    ]
}