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{ "count": 24779, "next": "http://api.gregory-ms.com/articles/?format=api&page=1349", "previous": "http://api.gregory-ms.com/articles/?format=api&page=1347", "results": [ { "article_id": 439941, "title": "Mature bone marrow-derived dendritic cells polarize Th2 response and suppress experimental autoimmune encephalomyelitis", "summary": "<jats:p> Distinct subsets of dendritic cells (DCs) based on the origin, phenotypes, and the nature of the signals that promote DC maturation can determine polarized immune responses of T cells. In this study, DCs were cultured from mouse bone marrow (BM) progenitors in granulocyte-macrophage colony-stimulating factor (GM-CSF). To generate mature DCs (mDCs), lipopolysaccharide (LPS) was used in the culture for 24 h. LPS-stimulated DCs were phenotypically mature, which exhibited strongly upregulated CD40, B7.1, and B7.2 compared to non-LPS-stimulated immature DCs (imDCs). Both mDCs and imDCs expressed high levels of MHC class II but low level of CD54. mDCs produced higher levels of IL-10 and lower IL-12 compared to imDCs. No IFN-g or IL-4 was found in both groups. When mDCs were injected intraperitoneally (i.p.) to the mice with experimental autoimmune encephalomyelitis (EAE), the severity of clinical signs and inflammation in the CNS was significantly suppressed compared to imDC-injected mice (p<0.01) and PBS-injected mice (p <0.02). Moreover, lymphocytes from mDC-injected mice produced lower level of IL-12, IFN-g, but higher level of IL-10, compared to imDC-injected and non-DC-injected mice. We conclude that BM-mDCs, but not BM-imDCs, promote Th2 differentiation and have the potential for suppression of inflammatory demyelination. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms857oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 297325, "given_name": "G-X", "family_name": "Zhang", "ORCID": null, "country": null }, { "author_id": 299468, "given_name": "M", "family_name": "Kishi", "ORCID": null, "country": null }, { "author_id": 299469, "given_name": "H", "family_name": "Xu", "ORCID": null, "country": null }, { "author_id": 299470, "given_name": "A", "family_name": "Rostami", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.631734Z", "noun_phrases": [ "Mature bone marrow-derived dendritic cells", "Th2 response", "suppress experimental autoimmune encephalomyelitis" ], "doi": "10.1191/1352458502ms857oa", "access": "restricted", "takeaways": " Dendritic cells (DCs) based on origin, phenotypes, and nature of the signals that promote DC maturation can determine polarized immune responses of T cells . DCs were cultured from mouse bone marrow (BM) progenitors in granulocyte-macrophage colony-stimulating factor (GM-CSF) To generate mature DCs (mDCs), lipopolysaccharide (LPS) was used in the culture for 24 h", "categories": [ { "category_id": 40, "category_description": "Autologous hematopoietic stem cell transplantation\n\nSearch terms: ahsct,Autologous hematopoietic stem cell transplantation,Bone marrow,Mesenchymal stem cells,Immunoablation", "category_name": "aHSCT", "category_slug": "ahsct", "category_terms": [ "ahsct", "Autologous hematopoietic stem cell transplantation", "Bone marrow", "Immunoablation" ], "article_count": 90 } ] }, { "article_id": 439940, "title": "Low interferon gamma producers are better treatment responders: a two-year follow-up of interferon beta-treated multiple sclerosis patients", "summary": "<jats:p> As response to interferon beta (IFNB) treatment, a 50% reduction of the mean relapse rate compared to pretreatment values has been reported. However, individual responses vary considerably, ranging from no reduction in exacerbation frequency to complete suppression of relapses for at least two years. At the moment, valid predictors for IFNB response are lacking. Here we present a prospective evaluation of 33 patients with primary relapsing multiple sclerosis, who were followed for two years of IFNB treatment. A low interferon gamma (IFG) production before treatment predicted a two-year term without exacerbations in 68.8% of cases correctly, whereas a high pretreatment IFG production implied the risk of at least one relapse in the first two years in 70.6%. These preliminary results encourage further evaluation of IFG as predictor of an IFNB treatment response. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms853oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 245243, "given_name": "H F", "family_name": "Petereit", "ORCID": null, "country": null }, { "author_id": 296585, "given_name": "S", "family_name": "Nolden", "ORCID": null, "country": null }, { "author_id": 296440, "given_name": "S", "family_name": "Schoppe", "ORCID": null, "country": null }, { "author_id": 245246, "given_name": "S", "family_name": "Bamborschke", "ORCID": null, "country": null }, { "author_id": 245245, "given_name": "R", "family_name": "Pukrop", "ORCID": null, "country": null }, { "author_id": 286663, "given_name": "W D", "family_name": "Heiss", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.630939Z", "noun_phrases": [ "Low interferon gamma producers", "better treatment responders", "a two-year follow-up", "interferon beta-treated multiple sclerosis patients" ], "doi": "10.1191/1352458502ms853oa", "access": "restricted", "takeaways": " As response to interferon beta (IFNB) treatment, a 50% reduction of the mean relapse rate compared to pretreatment values has been reported . Individual responses vary considerably, ranging from no reduction in exacerbation frequency to complete suppression of relapses for at least two years .", "categories": [] }, { "article_id": 439939, "title": "Quality of life in multiple sclerosis patients in Spain", "summary": "<jats:p> Objective: The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain. Methods: The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated. Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores. Results: Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach’s alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R<jats:sup>2</jats:sup>=0.51) and the total scores. Conclusions: The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms851oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 283461, "given_name": "C-H", "family_name": "Chang", "ORCID": null, "country": null }, { "author_id": 283462, "given_name": "D", "family_name": "Cella", "ORCID": null, "country": null }, { "author_id": 264305, "given_name": "O", "family_name": "Fernández", "ORCID": null, "country": null }, { "author_id": 264316, "given_name": "G", "family_name": "Luque", "ORCID": null, "country": null }, { "author_id": 283463, "given_name": "P", "family_name": "de Castro", "ORCID": null, "country": null }, { "author_id": 283464, "given_name": "C", "family_name": "de Andrés", "ORCID": null, "country": null }, { "author_id": 259603, "given_name": "B", "family_name": "Casanova", "ORCID": null, "country": null }, { "author_id": 283465, "given_name": "M A", "family_name": "Hernández", "ORCID": null, "country": null }, { "author_id": 283466, "given_name": "J M", "family_name": "Prieto", "ORCID": null, "country": null }, { "author_id": 283468, "given_name": "V E", "family_name": "Fernández", "ORCID": null, "country": null }, { "author_id": 283469, "given_name": "E", "family_name": "de Ramón", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.630195Z", "noun_phrases": [ "Quality", "life", "multiple sclerosis patients", "Spain" ], "doi": "10.1191/1352458502ms851oa", "access": "restricted", "takeaways": " The Functional Assessment of Multiple Sclerosis (FAMS) Spanish version was used to assess quality of life (QOL) of MS patients in Spain . The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS . Most of the patients are females (66%), and 74% were of the relapsing-remitting clinical subtype .", "categories": [] }, { "article_id": 439938, "title": "Susceptibility to Theiler’s murine encephalomyelitis virus-induced demyelinating disease in BALB/cAnNCr mice is related to absence of a CD4+ T-cell subset", "summary": "<jats:p> Two histocompatible substrains of BALB/c mice (BALB/cByJ, BALB/cAnNCr) are resistant and susceptible, respectively, to Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) - a model for viral etiology of human multiple sclerosis. BALB/cByJ mice become susceptible following low-dose irradiation given prior to infection. Resistance is restored by adoptive transfer of CD8<jats:sup>+</jats:sup> (but not CD4<jats:sup>+</jats:sup>) splenic T cells from infected, unirradiated BALB/cByJ donors. In contrast, resistance is conferred to BALB/cAnNCr mice by adoptive transfer of either CD4<jats:sup>+</jats:sup> or CD8<jats:sup>+</jats:sup> T cells from resistant BALB/cByJ donors. T cells from BALB/cAnNCr mice cannot confer protection. To integrate these two observations, we hypothesized that the BALB/cAnNCr mice possess precursors of the regulatory CD8<jats:sup>+</jats:sup> T cells, but fail to activate them because they lack a critical CD4<jats:sup>+</jats:sup> T-cell subpopulation. We tested this model using serial transfers. The transfer of CD4<jats:sup>+</jats:sup> T cells from the BALB/cByJ to the BALB/cAnNCr mice permitted development of BALB/cAnNCr CD8<jats:sup>+</jats:sup> T cells that, in turn, provided resistance when transferred into susceptible recipients. The BALB/cByJ CD4<jats:sup>+</jats:sup> T cells, which activated the CD8<jats:sup>+</jats:sup> cells, were sensitive to low-dose irradiation, unlike CD4<jats:sup>+</jats:sup> T cells involved in the later inflammatory demyelination. Thus, susceptibility of BALB/cAnNCr mice is due to a defective/absent CD4<jats:sup>+</jats:sup> T -cell subset acting immediately after infection. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms850oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 270948, "given_name": "K A", "family_name": "Karls", "ORCID": null, "country": null }, { "author_id": 270949, "given_name": "P W", "family_name": "Denton", "ORCID": null, "country": null }, { "author_id": 270950, "given_name": "R W", "family_name": "Melvold", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.629404Z", "noun_phrases": [ "Susceptibility", "Theiler’s murine encephalomyelitis virus-induced demyelinating disease", "BALB/cAnNCr mice", "absence", "a CD4+ T-cell subset" ], "doi": "10.1191/1352458502ms850oa", "access": "restricted", "takeaways": " BALB/c mice are resistant and susceptible to Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) - a model for viral etiology of human multiple sclerosis . BALBByJ mice become susceptible following low-dose irradiation given prior to infection . Resistance is restored by adoptive transfer of CD8+ (but not CD4+) splenic T cells from infected, unirradiated BALB", "categories": [] }, { "article_id": 439937, "title": "An examination of the association between b2 adrenergic receptor polymorphisms and multiple sclerosis", "summary": "<jats:p> In multiple sclerosis (MS), β-adrenergic receptor densities on peripheral blood mononuclear cells are enhanced, while the astrocytes present in plaques lack β2 adrenergic receptor (β2AR) expression. This differentially altered expression suggests that β2ARs may influence the pathogenesis of MS. In the present study, we investigated the association of polymorphisms of the β2AR gene with the occurrence of MS. Our results showed no significant differences in the distribution of the polymorphisms between MS patients overall and control subjects. Furthermore, no association was observed between the presence of β2AR gene polymorphisms and clinical characteristics, such as age at disease onset and disease severity. While a trend towards an increase of the Gly allele frequency in codon 16 was observed in the secondary-progressive MS, this result was not significantly different from that observed in relapsing-remitting MS patients or control subjects. Together, our findings suggest that the presence of β2AR gene polymorphisms may be inconclusive in the susceptibility to MS or in the clinical characteristics of Japanese patients with MS and, therefore, need further studies. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms848oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 245832, "given_name": "M", "family_name": "Niino", "ORCID": null, "country": null }, { "author_id": 263212, "given_name": "S", "family_name": "Kikuchi", "ORCID": null, "country": null }, { "author_id": 289299, "given_name": "R", "family_name": "Miyagishi", "ORCID": null, "country": null }, { "author_id": 263211, "given_name": "T", "family_name": "Fukazawa", "ORCID": null, "country": null }, { "author_id": 289300, "given_name": "I", "family_name": "Yabe", "ORCID": null, "country": null }, { "author_id": 300864, "given_name": "K", "family_name": "Tashiro", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.628665Z", "noun_phrases": [ "An examination", "the association", "b2 adrenergic receptor polymorphisms", "multiple sclerosis" ], "doi": "10.1191/1352458502ms848oa", "access": "restricted", "takeaways": " In MS, β-adrenergic receptor densities on peripheral blood mononuclear cells are enhanced, while astrocytes present in plaques lack β2 adrenergic receptor (β2AR) expression . This differentially altered expression suggests that β2ARs may influence the pathogenesis of MS .", "categories": [] }, { "article_id": 439936, "title": "Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters", "summary": "<jats:p> Objectives: Fatigue is one of the most common, yet poorly defined, disabling symptoms in patients with multiple sclerosis (MS). To delineate more clearly the frequency and type of fatigue, we first compared four widely used fatigue scales in consecutive MS patients. Secondly, to further clarify the nature of fatigue, we investigated its relation to physical disability, course of the disease, immunotherapy, and depression. Patients and Methods: Between February and September 2000, 151 consecutive MS patients entering our outpatient clinic (94 relapsing-remitting, 50 secondary progressive, and 7 primary progressive patients; mean age 29.0-7.3 years, mean disease duration 9.9-6.7 years, median EDSS 3.5) filled in a standardized questionnaire including four fatigue scales - Fatigue Severity Scale (FSS), MS-specific FSS (MFSS), Modified Fatigue Impact Scale (MFIS), and Visual Analogue Scale (VAS). Patients were included in the ‘MS-related fatigue group’ (MS-F) when they stated in the questionnaire that fatigue: 1) is one of their three most disabling symptoms; 2) occurs daily or on most of the days; and 3) limits their activities at home or at work. Patients fulfilling none of these criteria were classified as ‘MS-related nonfatigue group’ (MS-NF). Depression was measured by Beck’s Depression Inventory (BDI). Results: Although all scales showed significant differences between MS-F and MS-NF, correlation between these scales was, at best, moderate (correlation coefficients ranging from 0.06 to 0.56). The most discriminative scales were FSS and MFIS, showing no overlap of the 10th and 90th percentiles for the MS-F and MS-NF groups, with cut-off values of 4.6 and 38, respectively. Depression (BDI≥18) was present in 24 of 148 patients who filled in the BDI (16%). FSS was significantly correlated with physical disability (r =0.33, p <0.0001) and BDI (r =0.41, p<0.0001), but not with age, disease duration, clinical activity, and treatment with interferon-b. In multivariate analysis, however, only BDI independently predicted fatigue. Conclusions: The association of fatigue and depression suggests that there might be either common underlying mechanisms or interdependence by a cause-and-effect relationship that requires further investigation. The weak correlation within various fatigue scales is best explained by the fact that fatigue is a multidimensional symptom and, therefore, the available tests measure and weight different aspects of fatigue. Our findings underline the necessity for a more exact definition of fatigue and the development of more valid tools if these are to be used to evaluate treatments. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms839oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 243567, "given_name": "P", "family_name": "Flachenecker", "ORCID": null, "country": null }, { "author_id": 257107, "given_name": "T", "family_name": "Kümpfel", "ORCID": null, "country": null }, { "author_id": 280545, "given_name": "B", "family_name": "Kallmann", "ORCID": null, "country": null }, { "author_id": 280546, "given_name": "M", "family_name": "Gottschalk", "ORCID": null, "country": null }, { "author_id": 280547, "given_name": "O", "family_name": "Grauer", "ORCID": null, "country": null }, { "author_id": 248359, "given_name": "P", "family_name": "Rieckmann", "ORCID": null, "country": null }, { "author_id": 280548, "given_name": "C", "family_name": "Trenkwalder", "ORCID": null, "country": null }, { "author_id": 280549, "given_name": "K V", "family_name": "Toyka", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.627890Z", "noun_phrases": [ "Fatigue", "multiple sclerosis", "a comparison", "different rating scales", " correlation", "clinical parameters" ], "doi": "10.1191/1352458502ms839oa", "access": "restricted", "takeaways": " Fatigue is one of the most common, yet poorly defined, disabling symptoms in patients with multiple sclerosis . Fatigue Severity Scale (FSS), MS-specific FSS (MFSS), Modified Fatigue Impact Scale (MFIS), and Visual Analogue Scale (VAS) FSS was significantly correlated with physical disability (r =0.33, p <0.0001), but not with age, disease duration, clinical activity, and treatment with interferon-b", "categories": [] }, { "article_id": 439935, "title": "A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands", "summary": "<jats:p> The cerebrospinal fluid oligoclonal IgG bands (OB) are less frequently observed in Japanese multiple sclerosis (MS) patients compared with Caucasian patients. We studied 40 consecutive Japanese MS patients to investigate the differences in the clinical and magnetic resonance imaging (MRI) features of MS between OB-positive patients and OB-negative ones. Among the 40 patients, 22 (55%) patients were OB-positive by either agarose gel electrophoresis (AGE) or isoelectric focusing (IEF), and 18 (45%) patients were OB-negative by both AGE and IEF. There were differences between the two groups only in the clinical forms of MS, but not in terms of gender, onset age, disease duration, or disease severity. In the OB-negative group, nine (50%) of the patients had the optic-spinal form of MS (OS-MS), but only one patient (4.5%) in the OB-positive group had OS-MS. Although most OB-positive patients showed brain MRI lesions typical of MS, 13 (72%) of the OB-negative patients showed no or few brain MRI lesions and the rest of the OB-negative patients showed atypical MS lesions, such as diffuse white matter lesions or large ring-enhanced lesions. Our results suggest that the majority of OB-negative Japanese MS patients show either no or few brain MRI lesions or atypical brain MRI lesions. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms831oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 243612, "given_name": "I", "family_name": "Nakashima", "ORCID": null, "country": null }, { "author_id": 243614, "given_name": "K", "family_name": "Fujihara", "ORCID": null, "country": null }, { "author_id": 243616, "given_name": "T", "family_name": "Misu", "ORCID": null, "country": null }, { "author_id": 243618, "given_name": "J", "family_name": "Fujimori", "ORCID": null, "country": null }, { "author_id": 243620, "given_name": "S", "family_name": "Sato", "ORCID": null, "country": null }, { "author_id": 243621, "given_name": "S", "family_name": "Takase", "ORCID": null, "country": null }, { "author_id": 243622, "given_name": "Y", "family_name": "Itoyama", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.627148Z", "noun_phrases": [ "A comparative study", "Japanese multiple sclerosis patients", " oligoclonal IgG bands" ], "doi": "10.1191/1352458502ms831oa", "access": "restricted", "takeaways": " The cerebrospinal fluid oligoclonal IgG bands (OB) are less frequently observed in Japanese multiple sclerosis (MS) patients compared with Caucasian patients . We studied 40 consecutive Japanese MS patients to investigate differences in the clinical and magnetic resonance imaging features of MS .", "categories": [] }, { "article_id": 439934, "title": "TACE mRNA expression in peripheral mononuclear cells precedes new lesions on MRI in multiple sclerosis", "summary": "<jats:p> Tumor necrosis factor-a (TNF-a) is involved in the pathogenesis of multiple sclerosis (MS). It has to be released from its cell membrane-bound precursor by proteolytic cleavage. This is mainly performed by a member of the ADAM (a disintegrin and metalloproteinase) family of enzymes, TNF-a-converting enzyme (TACE, ADAM 17). In a longitudinal study on 11 relapsing-remitting MS patients, we qualitatively determined mRNA expression of TNF-a and TACE in peripheral blood mononuclear cells (PBMCs) without ex vivo stimulation. mRNA expression was related to disease activity as assessed by monthly gadolinium (Gd)-enhanced brain magnetic resonance imaging (MRI). Patients found positive for TACE mRNA in PBMCs showed a significantly higher mean number of new Gd-enhancing lesions per scan one month following PBMC sampling. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms830oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 269561, "given_name": "B C", "family_name": "Kieseier", "ORCID": null, "country": null }, { "author_id": 256290, "given_name": "S", "family_name": "Ropele", "ORCID": null, "country": null }, { "author_id": 256292, "given_name": "S", "family_name": "Strasser-Fuchs", "ORCID": null, "country": null }, { "author_id": 269562, "given_name": "F", "family_name": "Quehenberger", "ORCID": null, "country": null }, { "author_id": 255014, "given_name": "F", "family_name": "Fazekas", "ORCID": null, "country": null }, { "author_id": 246419, "given_name": "H-P", "family_name": "Hartung", "ORCID": null, "country": null }, { "author_id": 256291, "given_name": "T", "family_name": "Seifert", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.626354Z", "noun_phrases": [ "TACE mRNA expression", "peripheral mononuclear cells", "new lesions", " MRI", "multiple sclerosis" ], "doi": "10.1191/1352458502ms830oa", "access": "restricted", "takeaways": " Tumor necrosis factor-a (TNF-a) is involved in the pathogenesis of multiple sclerosis . It has to be released from its cell membrane-bound precursor by proteolytic cleavage . In a longitudinal study on 11 relapsing-remitting MS", "categories": [] }, { "article_id": 439933, "title": "Simple phonic tic in multiple sclerosis", "summary": "<jats:p> Movement disorders occurring in association with multiple sclerosis (MS) are rare. Among them paroxysmal dystonia is the most common, although chorea, ballism, palatal myoclonia, spasmodic torticollis, writer’s cramp and generalized dystonia have been reported. We describe a 34-year old woman with MS who developed simple phonic tic characterized by throat-clearing sounds. Magnetic resonance imaging showed demyelinating lesions involving the thalamus and basal ganglia. This is the first report of tic disorder occurring as a manifestation of MS. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms829oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 306516, "given_name": "M A", "family_name": "Lana-Peixoto", "ORCID": null, "country": null }, { "author_id": 306517, "given_name": "A L", "family_name": "Teixeira", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.625244Z", "noun_phrases": [ "Simple phonic tic", "multiple sclerosis" ], "doi": "10.1191/1352458502ms829oa", "access": "restricted", "takeaways": " Movement disorders occurring in association with multiple sclerosis are rare . Paroxysmal dystonia is the most common, but chorea, ballism, palatal myoclonia", "categories": [] }, { "article_id": 439932, "title": "Analyses of the minimum data set: comparisons of nursing home residents with multiple sclerosis to other nursing home residents", "summary": "<jats:p> This research compares nursing home residents with multiple sclerosis (MS) at admission to other nursing home residents using the minimum data set (MDS). These comparisons include sociodemographic characteristics and health status measures, as well as treatments and procedures received. We analysed 14,009 admission assessments in the MDS for residents with MS between June 22, 1998 and December 31, 2000. We also analysed 440,642 MDS admission assessments for all residents admitted to nursing homes during the year 2000, with any admission assessments for residents with MS excluded from this comparison group. Residents with MS were significantly younger at admission than other recently admitted residents. In addition, residents with MS tended to be significantly more physically disabled and also less cognitively impaired than other residents at admission, based on analyses of several measures of physical disability and cognitive performance. Nursing homes caring for residents with MS should provide services and programs, including mental health care, that address the needs of these younger, more physically disabled, and more cognitively intact residents. </jats:p>", "link": "https://journals.sagepub.com/doi/pdf/10.1191/1352458502ms823oa", "published_date": "2002-12-01T00:00:00Z", "sources": [ "SAGE Publications" ], "teams": [ { "id": 1, "name": "Team Gregory" } ], "subjects": [ { "subject_name": "Multiple Sclerosis", "description": null } ], "publisher": "SAGE Publications", "container_title": "Multiple Sclerosis Journal", "authors": [ { "author_id": 274442, "given_name": "R J", "family_name": "Buchanan", "ORCID": null, "country": null }, { "author_id": 274443, "given_name": "S", "family_name": "Wang", "ORCID": null, "country": null }, { "author_id": 274444, "given_name": "H", "family_name": "Ju", "ORCID": null, "country": null } ], "relevant": null, "ml_prediction_gnb": false, "ml_prediction_lr": false, "ml_prediction_lsvc": false, "discovery_date": "2022-06-09T10:40:10.624507Z", "noun_phrases": [ "Analyses", "the minimum data set", "comparisons", "nursing home residents", " multiple sclerosis", "other nursing home residents" ], "doi": "10.1191/1352458502ms823oa", "access": "restricted", "takeaways": " This research compares nursing home residents with multiple sclerosis (MS) at admission to other residents . It analysed 14,009 admission assessments in the MDS for residents with MS between June 22, 1998 and December 31, 2000 . Residents with MS tended to be significantly more physically disabled and less cognitively impaired than other residents at admission .", "categories": [] } ] }