List all articles in the database by earliest discovery_date

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    "count": 23938,
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    "results": [
        {
            "article_id": 386143,
            "title": "Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis",
            "summary": "Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6 months. Once the leading cause of mortality in scleroderma (SSc), it remains a serious complication, often necessitating level three care for patients affected. Whilst renal outcomes have significantly improved following the advent of angiotensin-converting enzyme inhibitor (ACEi) therapy, SRC remains a precarious challenge for clinicians, due to lack of preventative...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35648373/?fc=20210216052009&ff=20220601202006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Clinical Reviews in Allergy & Immunology",
            "authors": [
                {
                    "author_id": 173127,
                    "given_name": "Alice",
                    "family_name": "Cole",
                    "ORCID": "http://orcid.org/0000-0003-0268-4410",
                    "country": null
                },
                {
                    "author_id": 173128,
                    "given_name": "Voon H.",
                    "family_name": "Ong",
                    "ORCID": "http://orcid.org/0000-0001-5474-0053",
                    "country": null
                },
                {
                    "author_id": 150593,
                    "given_name": "Christopher",
                    "family_name": "Denton",
                    "ORCID": "http://orcid.org/0000-0003-3975-8938",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-02T00:20:06.143366Z",
            "noun_phrases": [
                "Renal Disease",
                "Systemic Sclerosis",
                "an Update",
                "Scleroderma Renal Crisis"
            ],
            "doi": "10.1007/s12016-022-08945-x",
            "access": "open",
            "takeaways": " Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6",
            "categories": []
        },
        {
            "article_id": 384170,
            "title": "Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty",
            "summary": "Tissue-resident memory T cells (T(RM)) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited trafficking through the circulation. These cells are characterized by expression of molecules enabling their tissue anchoring and downregulation of molecules promoting tissue egress. They reside at sites of previous antigen encounter and their number increases with age. T(RM) have been shown to provide rapid and efficient protection against tissue...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35644112/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Elsevier BV",
            "container_title": "Current Opinion in Immunology",
            "authors": [
                {
                    "author_id": 195688,
                    "given_name": "Doron",
                    "family_name": "Merkler",
                    "ORCID": "http://orcid.org/0000-0002-0247-2007",
                    "country": null
                },
                {
                    "author_id": 276018,
                    "given_name": "Ilena",
                    "family_name": "Vincenti",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 276088,
                    "given_name": "Frederick",
                    "family_name": "Masson",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 276090,
                    "given_name": "Roland S",
                    "family_name": "Liblau",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.770454Z",
            "noun_phrases": [
                "Tissue-resident CD8 T cells",
                "central nervous system inflammatory diseases",
                "the crime scene"
            ],
            "doi": "10.1016/j.coi.2022.102211",
            "access": "open",
            "takeaways": " Tissue-resident memory T cells (T(RM) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited",
            "categories": []
        },
        {
            "article_id": 384169,
            "title": "Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model",
            "summary": "A change in visual perception is a frequent early symptom of multiple sclerosis (MS), the pathoaetiology of which remains unclear. Following a slow demyelination process caused by 12 weeks of low-dose (0.1%) cuprizone (CPZ) consumption, histology and proteomics were used to investigate components of the visual pathway in young adult mice. Histological investigation did not identify demyelination or gliosis in the optic tracts, pretectal nuclei, superior colliculi, lateral geniculate nuclei or...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35644788/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Molecular Neuroscience",
            "authors": [
                {
                    "author_id": 212259,
                    "given_name": "Mohammed S. M.",
                    "family_name": "Almuslehi",
                    "ORCID": "http://orcid.org/0000-0002-2450-2449",
                    "country": null
                },
                {
                    "author_id": 207451,
                    "given_name": "Monokesh K.",
                    "family_name": "Sen",
                    "ORCID": "http://orcid.org/0000-0003-3988-9196",
                    "country": "BD"
                },
                {
                    "author_id": 207454,
                    "given_name": "Peter J.",
                    "family_name": "Shortland",
                    "ORCID": "http://orcid.org/0000-0002-7598-9744",
                    "country": "AU"
                },
                {
                    "author_id": 207452,
                    "given_name": "David A.",
                    "family_name": "Mahns",
                    "ORCID": "http://orcid.org/0000-0003-2131-9638",
                    "country": "AU"
                },
                {
                    "author_id": 207453,
                    "given_name": "Jens R.",
                    "family_name": "Coorssen",
                    "ORCID": "http://orcid.org/0000-0001-8048-7370",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.769758Z",
            "noun_phrases": [
                "Histological and Top-Down Proteomic Analyses",
                "the Visual Pathway",
                "the Cuprizone Demyelination Model"
            ],
            "doi": "10.1007/s12031-022-01997-w",
            "access": "open",
            "takeaways": " Histological investigation did not identify demyelination or gliosis in the optic tracts, pretectal nuclei, superior colliculi, lateral genic",
            "categories": []
        },
        {
            "article_id": 384168,
            "title": "Novel Heterozygous Variants in the <em>HLA-DRB1</em> Gene in a Saudi Family With Early-Onset Familial Multiple Sclerosis: Therapeutic Failure and Success",
            "summary": "Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system. Familial MS is arbitrarily defined as a type of MS that runs in families with 1 or more first- to third-degree relatives in addition to the index case affected by MS. The aim of this article is to report a unique case of familial MS from Saudi Arabia with 2 novel variants in the HLA-DRB1 gene that may contribute to the pathogenesis. We observed an unfavorable response to interferon therapy and...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645622/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 178604,
                    "given_name": "Hussein",
                    "family_name": "Algahtani",
                    "ORCID": "http://orcid.org/0000-0001-9484-9838",
                    "country": null
                },
                {
                    "author_id": 235197,
                    "given_name": "Bader",
                    "family_name": "Shirah",
                    "ORCID": "http://orcid.org/0000-0001-6493-2155",
                    "country": "SA"
                },
                {
                    "author_id": 309242,
                    "given_name": "Randa",
                    "family_name": "Khafaji",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309243,
                    "given_name": "Sarah",
                    "family_name": "Algahtani",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.769073Z",
            "noun_phrases": [
                "Novel Heterozygous Variants",
                "the <em>HLA-DRB1</em> Gene",
                "a Saudi Family",
                "Early-Onset Familial Multiple Sclerosis",
                "Therapeutic Failure",
                "Success"
            ],
            "doi": "10.7224/1537-2073.2020-125",
            "access": "open",
            "takeaways": " Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system . Familial MS is defined as a type of MS that runs in families with 1 or more first",
            "categories": []
        },
        {
            "article_id": 384167,
            "title": "Effects of Vibration Training on Cognition and Quality of Life in Individuals With Multiple Sclerosis",
            "summary": "CONCLUSIONS: These results suggest that vibration training could be an effective alternative training paradigm to enhance cognition and QOL in individuals with MS, and they provide an encouraging base to conduct a large-scale clinical trial.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645623/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 210036,
                    "given_name": "Feng",
                    "family_name": "Yang",
                    "ORCID": "http://orcid.org/0000-0001-7744-7626",
                    "country": null
                },
                {
                    "author_id": 278413,
                    "given_name": "Pey-Shan",
                    "family_name": "Wen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 254660,
                    "given_name": "Francois",
                    "family_name": "Bethoux",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 178997,
                    "given_name": "Yichuan",
                    "family_name": "Zhao",
                    "ORCID": "http://orcid.org/0000-0002-6567-0422",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.768458Z",
            "noun_phrases": [
                "Effects",
                "Vibration Training",
                "Cognition",
                "Quality",
                "Life",
                "Individuals",
                "Multiple Sclerosis"
            ],
            "doi": "10.7224/1537-2073.2020-095",
            "access": "open",
            "takeaways": "",
            "categories": []
        },
        {
            "article_id": 384166,
            "title": "Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review",
            "summary": "CONCLUSIONS: Sleep disturbances are a major contributor to NMOSD disease burden and may arise from the disruption of sleep circuitry, in addition to physical and psychological complications. Multiple processes involved in sleep regulation may be affected, such as, but not limited to, neural circadian circuit disruption, direct effects of inflammation, aminergic projecting system abnormalities, glymphatic system impairment, and development of sleep disorders such as restless legs syndrome/sleep...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645625/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 292300,
                    "given_name": "Arshia",
                    "family_name": "Eshtiaghi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 292301,
                    "given_name": "David",
                    "family_name": "Eapen-John",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 261203,
                    "given_name": "Kirill",
                    "family_name": "Zaslavsky",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 159565,
                    "given_name": "Reza",
                    "family_name": "Vosoughi",
                    "ORCID": "http://orcid.org/0000-0002-2337-1088",
                    "country": null
                },
                {
                    "author_id": 292304,
                    "given_name": "Brian J.",
                    "family_name": "Murray",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 194597,
                    "given_name": "Edward",
                    "family_name": "Margolin",
                    "ORCID": "http://orcid.org/0000-0002-6738-7225",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.767725Z",
            "noun_phrases": [
                "Quality",
                "Neuromyelitis Optica Spectrum Disorder"
            ],
            "doi": "10.7224/1537-2073.2021-019",
            "access": "open",
            "takeaways": " Sleep disturbances are a major contributor to NMOSD disease burden and may arise from the disruption of sleep circuitry . Multiple processes involved in sleep regulation may be",
            "categories": []
        },
        {
            "article_id": 384165,
            "title": "Managing Cognitive Dysfunction in Multiple Sclerosis: A Snapshot of Changes in Screening, Assessment, and Treatment Practices",
            "summary": "CONCLUSIONS: Clinical practices are becoming more in line with the literature, with increased use of cognitive screening and remediation. Continued attention to cognitive problems will be an ongoing important component of MS-related care.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645626/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 162434,
                    "given_name": "Elizabeth S.",
                    "family_name": "Gromisch",
                    "ORCID": "http://orcid.org/0000-0001-6928-3596",
                    "country": null
                },
                {
                    "author_id": 167316,
                    "given_name": "John",
                    "family_name": "DeLuca",
                    "ORCID": "http://orcid.org/0000-0003-3745-4156",
                    "country": "US"
                },
                {
                    "author_id": 173959,
                    "given_name": "Ralph H.B.",
                    "family_name": "Benedict",
                    "ORCID": "http://orcid.org/0000-0002-2080-3631",
                    "country": null
                },
                {
                    "author_id": 248978,
                    "given_name": "Frederick W.",
                    "family_name": "Foley",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.766884Z",
            "noun_phrases": [
                "Cognitive Dysfunction",
                "Multiple Sclerosis",
                "Changes",
                "Screening",
                "Assessment",
                "Treatment Practices"
            ],
            "doi": "10.7224/1537-2073.2020-139",
            "access": "open",
            "takeaways": "",
            "categories": []
        },
        {
            "article_id": 384164,
            "title": "Motivation for Physical Activity in Adults With Multiple Sclerosis: A Self-determination Theory-Based Approach",
            "summary": "CONCLUSIONS: Increasing satisfaction of the need for relatedness, competence, and autonomy can lead to more integrated and internally motivated PA engagement in adults with MS.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645627/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 251804,
                    "given_name": "Narissa",
                    "family_name": "McCarty",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 251805,
                    "given_name": "Samantha",
                    "family_name": "Sayer",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 155010,
                    "given_name": "Susan L.",
                    "family_name": "Kasser",
                    "ORCID": "http://orcid.org/0000-0001-7095-4414",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.766176Z",
            "noun_phrases": [
                "Motivation",
                "Physical Activity",
                "Adults",
                "Multiple Sclerosis",
                "A Self-determination Theory-Based Approach"
            ],
            "doi": "10.7224/1537-2073.2020-091",
            "access": "open",
            "takeaways": "",
            "categories": []
        },
        {
            "article_id": 384163,
            "title": "The Impact of COVID-19 on the Lives of Individuals With Multiple Sclerosis: 1 Year Into the Pandemic",
            "summary": "CONCLUSIONS: During the first year of the pandemic, this study found no pronounced impact on the emotional, social, or economic stability of the individuals with MS it surveyed. It seems that these study participants adapted to the restrictions created by the pandemic and, by adhering to guidelines, protected themselves from contracting SARS-CoV-2.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645628/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 236905,
                    "given_name": "Sharon",
                    "family_name": "Lynch",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 207265,
                    "given_name": "Sara",
                    "family_name": "Baker",
                    "ORCID": "http://orcid.org/0000-0003-0648-0191",
                    "country": null
                },
                {
                    "author_id": 299241,
                    "given_name": "Suzanne",
                    "family_name": "Hunt",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 236907,
                    "given_name": "Amanda",
                    "family_name": "Thuringer",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 299242,
                    "given_name": "Yasir",
                    "family_name": "Jassam",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 236909,
                    "given_name": "Jared",
                    "family_name": "Bruce",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.765335Z",
            "noun_phrases": [
                "The Impact",
                "COVID-19",
                "the Lives",
                "Individuals",
                "Multiple Sclerosis",
                "1 Year",
                "the Pandemic"
            ],
            "doi": "10.7224/1537-2073.2021-099",
            "access": "open",
            "takeaways": " During the first year of the pandemic, this study found no pronounced impact on the emotional, social, or economic",
            "categories": []
        },
        {
            "article_id": 384162,
            "title": "Self-reported Reasons for Changes in Performance of Daily Activities During a 2-Year Multidisciplinary Multiple Sclerosis Rehabilitation",
            "summary": "CONCLUSIONS: The outpatient rehabilitation program, including 4 themes-cognition, mood, energy conservation, and body control-improved the self-reported performance of patients with MS with moderate and severe disabilities. Environmental factors warrant consideration during rehabilitation.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645629/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 153908,
                    "given_name": "Maarit E.",
                    "family_name": "Karhula",
                    "ORCID": "http://orcid.org/0000-0003-0464-202X",
                    "country": null
                },
                {
                    "author_id": 250480,
                    "given_name": "Katja",
                    "family_name": "Kanelisto",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 177576,
                    "given_name": "Päivi",
                    "family_name": "Hämäläinen",
                    "ORCID": "http://orcid.org/0000-0002-9020-4650",
                    "country": null
                },
                {
                    "author_id": 250484,
                    "given_name": "Juhani",
                    "family_name": "Ruutiainen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 250486,
                    "given_name": "Pertti",
                    "family_name": "Era",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 250488,
                    "given_name": "Arja",
                    "family_name": "Häkkinen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 250490,
                    "given_name": "Anna-Liisa",
                    "family_name": "Salminen",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.764674Z",
            "noun_phrases": [
                "Self-reported Reasons",
                "Changes",
                "Performance",
                "Daily Activities",
                "a 2-Year Multidisciplinary Multiple Sclerosis Rehabilitation"
            ],
            "doi": "10.7224/1537-2073.2020-061",
            "access": "open",
            "takeaways": "",
            "categories": []
        }
    ]
}