List all articles in the database by earliest discovery_date

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    "results": [
        {
            "article_id": 387845,
            "title": "Curcumin-based nanotechnology approaches and therapeutics in restoration of autoimmune diseases",
            "summary": "Autoimmune diseases usually arise as a result of an aberrant immune system attack on normal tissues of the body, which leads to a cascade of inflammatory reactions. The immune system employs different types of protective and anti-inflammatory cells for the regulation of this process. Curcumin is a known natural anti-inflammatory agent that inhibits pathological autoimmune processes by regulating inflammatory cytokines and their associated signaling pathways in immune cells. Due to the unstable...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35649486/?fc=20210216052009&ff=20220602015005&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Elsevier BV",
            "container_title": "Journal of Controlled Release",
            "authors": [
                {
                    "author_id": 237436,
                    "given_name": "Niloufar",
                    "family_name": "Rahiman",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 273681,
                    "given_name": "Yuliya V.",
                    "family_name": "Markina",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 273682,
                    "given_name": "Prashant",
                    "family_name": "Kesharwani",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 235106,
                    "given_name": "Thomas P.",
                    "family_name": "Johnston",
                    "ORCID": "http://orcid.org/0000-0003-4666-5334",
                    "country": null
                },
                {
                    "author_id": 199535,
                    "given_name": "Amirhossein",
                    "family_name": "Sahebkar",
                    "ORCID": "http://orcid.org/0000-0002-8656-1444",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-02T05:50:05.938050Z",
            "noun_phrases": [
                "Curcumin-based nanotechnology approaches",
                "therapeutics",
                "restoration",
                "autoimmune diseases"
            ],
            "doi": "10.1016/j.jconrel.2022.05.046",
            "access": "restricted",
            "takeaways": " Curcumin is a known natural anti-inflammatory agent that inhibits pathological autoimmune processes . Autoimmune diseases usually arise as a result of an aberrant immune system attack on",
            "categories": []
        },
        {
            "article_id": 387844,
            "title": "Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study",
            "summary": "CONCLUSION: Higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. The findings suggest that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35649699/?fc=20210216052009&ff=20220602015005&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "BMJ",
            "container_title": "Journal of Neurology, Neurosurgery & Psychiatry",
            "authors": [
                {
                    "author_id": 190362,
                    "given_name": "Ingrid Anne",
                    "family_name": "Lie",
                    "ORCID": "http://orcid.org/0000-0002-9948-2411",
                    "country": null
                },
                {
                    "author_id": 190363,
                    "given_name": "Sezgi",
                    "family_name": "Kaçar",
                    "ORCID": "http://orcid.org/0000-0002-6695-2667",
                    "country": null
                },
                {
                    "author_id": 143724,
                    "given_name": "Kristin",
                    "family_name": "Wesnes",
                    "ORCID": "http://orcid.org/0000-0002-0918-8367",
                    "country": "NO"
                },
                {
                    "author_id": 198584,
                    "given_name": "Iman",
                    "family_name": "Brouwer",
                    "ORCID": "http://orcid.org/0000-0002-0408-0461",
                    "country": null
                },
                {
                    "author_id": 289642,
                    "given_name": "Silje S",
                    "family_name": "Kvistad",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 184120,
                    "given_name": "Stig",
                    "family_name": "Wergeland",
                    "ORCID": "http://orcid.org/0000-0002-7645-7686",
                    "country": "NO"
                },
                {
                    "author_id": 194636,
                    "given_name": "Trygve",
                    "family_name": "Holmøy",
                    "ORCID": "http://orcid.org/0000-0002-2529-5664",
                    "country": null
                },
                {
                    "author_id": 143730,
                    "given_name": "Rune",
                    "family_name": "Midgard",
                    "ORCID": "http://orcid.org/0000-0002-6096-726X",
                    "country": null
                },
                {
                    "author_id": 237471,
                    "given_name": "Alla",
                    "family_name": "Bru",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 237472,
                    "given_name": "Astrid",
                    "family_name": "Edland",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 143733,
                    "given_name": "Randi",
                    "family_name": "Eikeland",
                    "ORCID": "http://orcid.org/0000-0003-0104-9626",
                    "country": null
                },
                {
                    "author_id": 237473,
                    "given_name": "Sonia",
                    "family_name": "Gosal",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 256878,
                    "given_name": "Hanne F",
                    "family_name": "Harbo",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 143736,
                    "given_name": "Grethe",
                    "family_name": "Kleveland",
                    "ORCID": "http://orcid.org/0000-0001-9658-9582",
                    "country": null
                },
                {
                    "author_id": 289643,
                    "given_name": "Yvonne S",
                    "family_name": "Sørenes",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 237475,
                    "given_name": "Nina",
                    "family_name": "Øksendal",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 289644,
                    "given_name": "Kristin N",
                    "family_name": "Varhaug",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 190367,
                    "given_name": "Christian A",
                    "family_name": "Vedeler",
                    "ORCID": "http://orcid.org/0000-0002-0993-8906",
                    "country": null
                },
                {
                    "author_id": 143261,
                    "given_name": "Frederik",
                    "family_name": "Barkhof",
                    "ORCID": "http://orcid.org/0000-0003-3543-3706",
                    "country": null
                },
                {
                    "author_id": 247889,
                    "given_name": "Charlotte E",
                    "family_name": "Teunissen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 191799,
                    "given_name": "Lars",
                    "family_name": "Bø",
                    "ORCID": "http://orcid.org/0000-0001-8675-4433",
                    "country": null
                },
                {
                    "author_id": 163680,
                    "given_name": "Øivind",
                    "family_name": "Torkildsen",
                    "ORCID": "http://orcid.org/0000-0001-5294-2866",
                    "country": "NO"
                },
                {
                    "author_id": 184116,
                    "given_name": "Kjell-Morten",
                    "family_name": "Myhr",
                    "ORCID": "http://orcid.org/0000-0002-0980-510X",
                    "country": null
                },
                {
                    "author_id": 149817,
                    "given_name": "Hugo",
                    "family_name": "Vrenken",
                    "ORCID": "http://orcid.org/0000-0001-9106-1172",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-02T05:50:04.997749Z",
            "noun_phrases": [
                "Serum",
                "a predictor",
                "10-year grey matter atrophy",
                "clinical disability",
                "multiple sclerosis",
                ": a longitudinal study"
            ],
            "doi": "10.1136/jnnp-2021-328568",
            "access": "open",
            "takeaways": "",
            "categories": []
        },
        {
            "article_id": 386145,
            "title": "Retinal inner nuclear layer thinning is decreased and associates with the clinical outcome in ocrelizumab-treated primary progressive multiple sclerosis",
            "summary": "CONCLUSIONS: Ocrelizumab significantly slows down INL thinning rate in PPMS responders. The longitudinal analysis of retina layer changes by means of OCT may be a promising prognostic test, and merits further investigations.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35648233/?fc=20210216052009&ff=20220601202006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Neurology",
            "authors": [
                {
                    "author_id": 236920,
                    "given_name": "Paola",
                    "family_name": "Perini",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 244434,
                    "given_name": "Paolo",
                    "family_name": "Gallo",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 201798,
                    "given_name": "Alessandro",
                    "family_name": "Miscioscia",
                    "ORCID": "http://orcid.org/0000-0001-7465-6246",
                    "country": null
                },
                {
                    "author_id": 166742,
                    "given_name": "Marco",
                    "family_name": "Puthenparampil",
                    "ORCID": "http://orcid.org/0000-0002-2313-8462",
                    "country": null
                },
                {
                    "author_id": 193512,
                    "given_name": "Silvia",
                    "family_name": "Miante",
                    "ORCID": "http://orcid.org/0000-0001-7302-9419",
                    "country": null
                },
                {
                    "author_id": 291597,
                    "given_name": "Marta",
                    "family_name": "Pengo",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 244596,
                    "given_name": "Francesca",
                    "family_name": "Rinaldi",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-02T00:20:07.381116Z",
            "noun_phrases": [
                "Retinal inner nuclear layer thinning",
                "the clinical outcome",
                "ocrelizumab-treated primary progressive multiple sclerosis"
            ],
            "doi": "10.1007/s00415-022-11183-y",
            "access": "open",
            "takeaways": "",
            "categories": [
                {
                    "category_id": 8,
                    "category_description": "",
                    "category_name": "Ocrelizumab",
                    "category_slug": "ocrelizumab",
                    "category_terms": [
                        "ocrelizumab",
                        "ocrevus"
                    ],
                    "article_count": 218
                }
            ]
        },
        {
            "article_id": 386144,
            "title": "Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome",
            "summary": "Multiple sclerosis (MS) is a kind of central nervous system (CNS) autoimmune disease, which mainly damages nerves, the brain, and the spinal cord. Recently, several clinical cases reported the relativity between Coronavirus Disease 2019 (COVID-19) and the development of MS, but the mechanism of how COVID-19 affects the occurrence of MS was still not clear. It is bioinformatics technology that we use to explore the potential association at the gene level. The genetic information related to the...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35648256/?fc=20210216052009&ff=20220601202006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Neural Transmission",
            "authors": [
                {
                    "author_id": 309687,
                    "given_name": "Dong",
                    "family_name": "Qiu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309688,
                    "given_name": "Dongtai",
                    "family_name": "Zhang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309689,
                    "given_name": "Zhenyang",
                    "family_name": "Yu",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309690,
                    "given_name": "Yiwen",
                    "family_name": "Jiang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 229544,
                    "given_name": "Dan",
                    "family_name": "Zhu",
                    "ORCID": "http://orcid.org/0000-0001-8836-4906",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-02T00:20:07.379961Z",
            "noun_phrases": [
                "Bioinformatics approach",
                "the critical role",
                "the NOD-like receptor",
                "pathway",
                "COVID-19-associated multiple sclerosis syndrome"
            ],
            "doi": "10.1007/s00702-022-02518-0",
            "access": "open",
            "takeaways": " Multiple sclerosis (MS) is a kind of central nervous system (CNS) autoimmune disease . It mainly damages nerves, the brain, and the spinal cord . Coronav",
            "categories": []
        },
        {
            "article_id": 386143,
            "title": "Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis",
            "summary": "Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6 months. Once the leading cause of mortality in scleroderma (SSc), it remains a serious complication, often necessitating level three care for patients affected. Whilst renal outcomes have significantly improved following the advent of angiotensin-converting enzyme inhibitor (ACEi) therapy, SRC remains a precarious challenge for clinicians, due to lack of preventative...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35648373/?fc=20210216052009&ff=20220601202006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Clinical Reviews in Allergy & Immunology",
            "authors": [
                {
                    "author_id": 173127,
                    "given_name": "Alice",
                    "family_name": "Cole",
                    "ORCID": "http://orcid.org/0000-0003-0268-4410",
                    "country": null
                },
                {
                    "author_id": 173128,
                    "given_name": "Voon H.",
                    "family_name": "Ong",
                    "ORCID": "http://orcid.org/0000-0001-5474-0053",
                    "country": null
                },
                {
                    "author_id": 150593,
                    "given_name": "Christopher",
                    "family_name": "Denton",
                    "ORCID": "http://orcid.org/0000-0003-3975-8938",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-02T00:20:06.143366Z",
            "noun_phrases": [
                "Renal Disease",
                "Systemic Sclerosis",
                "an Update",
                "Scleroderma Renal Crisis"
            ],
            "doi": "10.1007/s12016-022-08945-x",
            "access": "open",
            "takeaways": " Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6",
            "categories": []
        },
        {
            "article_id": 384170,
            "title": "Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty",
            "summary": "Tissue-resident memory T cells (T(RM)) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited trafficking through the circulation. These cells are characterized by expression of molecules enabling their tissue anchoring and downregulation of molecules promoting tissue egress. They reside at sites of previous antigen encounter and their number increases with age. T(RM) have been shown to provide rapid and efficient protection against tissue...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35644112/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Elsevier BV",
            "container_title": "Current Opinion in Immunology",
            "authors": [
                {
                    "author_id": 195688,
                    "given_name": "Doron",
                    "family_name": "Merkler",
                    "ORCID": "http://orcid.org/0000-0002-0247-2007",
                    "country": null
                },
                {
                    "author_id": 276018,
                    "given_name": "Ilena",
                    "family_name": "Vincenti",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 276088,
                    "given_name": "Frederick",
                    "family_name": "Masson",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 276090,
                    "given_name": "Roland S",
                    "family_name": "Liblau",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.770454Z",
            "noun_phrases": [
                "Tissue-resident CD8 T cells",
                "central nervous system inflammatory diseases",
                "the crime scene"
            ],
            "doi": "10.1016/j.coi.2022.102211",
            "access": "open",
            "takeaways": " Tissue-resident memory T cells (T(RM) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited",
            "categories": []
        },
        {
            "article_id": 384169,
            "title": "Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model",
            "summary": "A change in visual perception is a frequent early symptom of multiple sclerosis (MS), the pathoaetiology of which remains unclear. Following a slow demyelination process caused by 12 weeks of low-dose (0.1%) cuprizone (CPZ) consumption, histology and proteomics were used to investigate components of the visual pathway in young adult mice. Histological investigation did not identify demyelination or gliosis in the optic tracts, pretectal nuclei, superior colliculi, lateral geniculate nuclei or...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35644788/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Molecular Neuroscience",
            "authors": [
                {
                    "author_id": 212259,
                    "given_name": "Mohammed S. M.",
                    "family_name": "Almuslehi",
                    "ORCID": "http://orcid.org/0000-0002-2450-2449",
                    "country": null
                },
                {
                    "author_id": 207451,
                    "given_name": "Monokesh K.",
                    "family_name": "Sen",
                    "ORCID": "http://orcid.org/0000-0003-3988-9196",
                    "country": "BD"
                },
                {
                    "author_id": 207454,
                    "given_name": "Peter J.",
                    "family_name": "Shortland",
                    "ORCID": "http://orcid.org/0000-0002-7598-9744",
                    "country": "AU"
                },
                {
                    "author_id": 207452,
                    "given_name": "David A.",
                    "family_name": "Mahns",
                    "ORCID": "http://orcid.org/0000-0003-2131-9638",
                    "country": "AU"
                },
                {
                    "author_id": 207453,
                    "given_name": "Jens R.",
                    "family_name": "Coorssen",
                    "ORCID": "http://orcid.org/0000-0001-8048-7370",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.769758Z",
            "noun_phrases": [
                "Histological and Top-Down Proteomic Analyses",
                "the Visual Pathway",
                "the Cuprizone Demyelination Model"
            ],
            "doi": "10.1007/s12031-022-01997-w",
            "access": "open",
            "takeaways": " Histological investigation did not identify demyelination or gliosis in the optic tracts, pretectal nuclei, superior colliculi, lateral genic",
            "categories": []
        },
        {
            "article_id": 384168,
            "title": "Novel Heterozygous Variants in the <em>HLA-DRB1</em> Gene in a Saudi Family With Early-Onset Familial Multiple Sclerosis: Therapeutic Failure and Success",
            "summary": "Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system. Familial MS is arbitrarily defined as a type of MS that runs in families with 1 or more first- to third-degree relatives in addition to the index case affected by MS. The aim of this article is to report a unique case of familial MS from Saudi Arabia with 2 novel variants in the HLA-DRB1 gene that may contribute to the pathogenesis. We observed an unfavorable response to interferon therapy and...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645622/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 178604,
                    "given_name": "Hussein",
                    "family_name": "Algahtani",
                    "ORCID": "http://orcid.org/0000-0001-9484-9838",
                    "country": null
                },
                {
                    "author_id": 235197,
                    "given_name": "Bader",
                    "family_name": "Shirah",
                    "ORCID": "http://orcid.org/0000-0001-6493-2155",
                    "country": "SA"
                },
                {
                    "author_id": 309242,
                    "given_name": "Randa",
                    "family_name": "Khafaji",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 309243,
                    "given_name": "Sarah",
                    "family_name": "Algahtani",
                    "ORCID": null,
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.769073Z",
            "noun_phrases": [
                "Novel Heterozygous Variants",
                "the <em>HLA-DRB1</em> Gene",
                "a Saudi Family",
                "Early-Onset Familial Multiple Sclerosis",
                "Therapeutic Failure",
                "Success"
            ],
            "doi": "10.7224/1537-2073.2020-125",
            "access": "open",
            "takeaways": " Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system . Familial MS is defined as a type of MS that runs in families with 1 or more first",
            "categories": []
        },
        {
            "article_id": 384167,
            "title": "Effects of Vibration Training on Cognition and Quality of Life in Individuals With Multiple Sclerosis",
            "summary": "CONCLUSIONS: These results suggest that vibration training could be an effective alternative training paradigm to enhance cognition and QOL in individuals with MS, and they provide an encouraging base to conduct a large-scale clinical trial.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645623/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 210036,
                    "given_name": "Feng",
                    "family_name": "Yang",
                    "ORCID": "http://orcid.org/0000-0001-7744-7626",
                    "country": null
                },
                {
                    "author_id": 278413,
                    "given_name": "Pey-Shan",
                    "family_name": "Wen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 254660,
                    "given_name": "Francois",
                    "family_name": "Bethoux",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 178997,
                    "given_name": "Yichuan",
                    "family_name": "Zhao",
                    "ORCID": "http://orcid.org/0000-0002-6567-0422",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.768458Z",
            "noun_phrases": [
                "Effects",
                "Vibration Training",
                "Cognition",
                "Quality",
                "Life",
                "Individuals",
                "Multiple Sclerosis"
            ],
            "doi": "10.7224/1537-2073.2020-095",
            "access": "open",
            "takeaways": "",
            "categories": []
        },
        {
            "article_id": 384166,
            "title": "Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review",
            "summary": "CONCLUSIONS: Sleep disturbances are a major contributor to NMOSD disease burden and may arise from the disruption of sleep circuitry, in addition to physical and psychological complications. Multiple processes involved in sleep regulation may be affected, such as, but not limited to, neural circadian circuit disruption, direct effects of inflammation, aminergic projecting system abnormalities, glymphatic system impairment, and development of sleep disorders such as restless legs syndrome/sleep...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/35645625/?fc=20210216052009&ff=20220601135006&v=2.17.6",
            "published_date": "2022-06-01T10:00:00Z",
            "source": "PubMed",
            "publisher": "Consortium of Multiple Sclerosis Centers",
            "container_title": "International Journal of MS Care",
            "authors": [
                {
                    "author_id": 292300,
                    "given_name": "Arshia",
                    "family_name": "Eshtiaghi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 292301,
                    "given_name": "David",
                    "family_name": "Eapen-John",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 261203,
                    "given_name": "Kirill",
                    "family_name": "Zaslavsky",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 159565,
                    "given_name": "Reza",
                    "family_name": "Vosoughi",
                    "ORCID": "http://orcid.org/0000-0002-2337-1088",
                    "country": null
                },
                {
                    "author_id": 292304,
                    "given_name": "Brian J.",
                    "family_name": "Murray",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 194597,
                    "given_name": "Edward",
                    "family_name": "Margolin",
                    "ORCID": "http://orcid.org/0000-0002-6738-7225",
                    "country": null
                }
            ],
            "relevant": null,
            "ml_prediction_gnb": false,
            "ml_prediction_lr": false,
            "ml_prediction_lsvc": false,
            "discovery_date": "2022-06-01T17:50:07.767725Z",
            "noun_phrases": [
                "Quality",
                "Neuromyelitis Optica Spectrum Disorder"
            ],
            "doi": "10.7224/1537-2073.2021-019",
            "access": "open",
            "takeaways": " Sleep disturbances are a major contributor to NMOSD disease burden and may arise from the disruption of sleep circuitry . Multiple processes involved in sleep regulation may be",
            "categories": []
        }
    ]
}