List all articles in the database by earliest discovery_date

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{
    "count": 26469,
    "next": "http://api.gregory-ms.com/articles/?page=2",
    "previous": null,
    "results": [
        {
            "article_id": 285857,
            "title": "Safety of fingolimod in patients with relapsing remitting multiple sclerosis: A descriptive analysis of data from the EudraVigilance database",
            "summary": "The most prevalent disease course of Multiple Sclerosis (MS) is relapsing remitting multiple sclerosis (RRMS). Fingolimod (Gilenya®) was the first oral disease-modifying therapy to RRMS. Patients affected by MS require long-term treatment, making the ongoing evaluation of the safety profile of fingolimod imperative. The aim of this study was to analyze the post-marketing pharmacovigilance data of fingolimod in Europe. Data of 12-year period (1 January 2011-19 June 2023) were obtained from...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002188/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "Journal of the Neurological Sciences",
            "authors": [
                {
                    "author_id": 359849,
                    "given_name": "Victoria",
                    "family_name": "Nikitina",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359850,
                    "given_name": "Greta",
                    "family_name": "Santi Laurini",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359851,
                    "given_name": "Nicola",
                    "family_name": "Montanaro",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359852,
                    "given_name": "Domenico",
                    "family_name": "Motola",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:28:09.042592Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.jns.2024.123132",
            "access": "open",
            "takeaways": "Fingolimod (Gilenya) was the first oral disease-modifying therapy to RRMS. The most prevalent disease course of MS",
            "team_categories": [
                {
                    "id": 35,
                    "category_name": "Fingolimod",
                    "category_description": "Fingolimod, also known as Gilenya is a type of medicine known as a ‘disease-modifying therapy’ that is used to treat adults and children over 10 years of age with highly active relapsing-remitting multiple sclerosis (MS), a disease of the nerves in which inflammation destroys the protective sheath surrounding the nerve cells. ‘Relapsing-remitting’ means that the patient has flare-ups of symptoms (relapses) followed by periods of recovery (remissions). Gilenya is used when the disease remains active despite appropriate treatment with at least one other disease-modifying therapy, or is severe and getting worse rapidly.\r\n\r\nhttps://www.ema.europa.eu/en/medicines/human/EPAR/gilenya",
                    "category_slug": "fingolimod",
                    "category_terms": [
                        "fingolimod",
                        "gilenya"
                    ]
                }
            ],
            "ml_predictions": []
        },
        {
            "article_id": 285856,
            "title": "The role of integrins in brain health and neurodegenerative diseases",
            "summary": "Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer's...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002282/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "European Journal of Cell Biology",
            "authors": [
                {
                    "author_id": 359847,
                    "given_name": "Yunhao",
                    "family_name": "Cui",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 353263,
                    "given_name": "Taisia",
                    "family_name": "Rolova",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359848,
                    "given_name": "Susanna C.",
                    "family_name": "Fagerholm",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:28:07.851020Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.ejcb.2024.151441",
            "access": "open",
            "takeaways": "Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285855,
            "title": "Cognitive-motor dual task to reveal gait impairments in multiple sclerosis patients at an early stage: A systematic review",
            "summary": "BACKGROUND: Multiple sclerosis can cause locomotor and cognitive impairments even at lower levels of disability, which can impact daily life. The cognitive-motor dual task is commonly used to assess everyday locomotion. Thus, this study aimed to examine the effect of cognitive-motor dual tasks on gait parameters among patients with multiple sclerosis in the early disease stages and to determine whether dual tasks could be used as a clinical test to detect locomotion impairments.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002455/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "Clinical Biomechanics",
            "authors": [
                {
                    "author_id": 359845,
                    "given_name": "David",
                    "family_name": "Péron",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 282647,
                    "given_name": "Sébastien",
                    "family_name": "Leteneur",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 299298,
                    "given_name": "Bruno",
                    "family_name": "Lenne",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359846,
                    "given_name": "Ghassan",
                    "family_name": "Ido",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 250338,
                    "given_name": "Cécile",
                    "family_name": "Donzé",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 282644,
                    "given_name": "Franck",
                    "family_name": "Barbier",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 255100,
                    "given_name": "Caroline",
                    "family_name": "Massot",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:28:06.344484Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.clinbiomech.2024.106300",
            "access": "restricted",
            "takeaways": "Multiple sclerosis can cause locomotor and cognitive impairments even at lower levels of disability. The cognitive-motor dual task is commonly used to assess everyday locomotion.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285854,
            "title": "A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4",
            "summary": "Neuroinflammation and neurodegeneration are hallmarks of multiple sclerosis (MS). Bromodomain-containing protein 4 (BRD4), a bromodomain and extra-terminal domain (BET) protein family member, is indispensable for the transcription of pro-inflammatory genes. Therefore, inhibiting BRD4 may be a prospective therapeutic approach for modulating the inflammatory response and regulating the course of MS. dBET1, a newly synthesized proteolysis-targeting chimera (PROTAC), exhibits effectively degrades of...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002520/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "International Immunopharmacology",
            "authors": [
                {
                    "author_id": 359841,
                    "given_name": "Ziwei",
                    "family_name": "Song",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 284157,
                    "given_name": "Jin",
                    "family_name": "Li",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 280879,
                    "given_name": "Yijie",
                    "family_name": "He",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359842,
                    "given_name": "Xiaokun",
                    "family_name": "Wang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359843,
                    "given_name": "Jianan",
                    "family_name": "Tian",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359844,
                    "given_name": "Yun",
                    "family_name": "Wu",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:28:04.944562Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.intimp.2024.112646",
            "access": "restricted",
            "takeaways": "Neuroinflammation and neurodegeneration are hallmarks of MS. Bromodomain-containing protein 4 (BRD4",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285853,
            "title": "Rationale and methodology for examining the combination of aerobic exercise and cognitive rehabilitation on new learning and memory in persons with multiple sclerosis and mobility disability: Protocol for a randomized controlled trial",
            "summary": "CONCLUSION: If successful, this trial will provide the first Class I evidence supporting the unique combination of aerobic cycling exercise with VR and CR for treating MS-related learning and memory impairments in persons with mobility disability.",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39002892/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "Contemporary Clinical Trials",
            "authors": [
                {
                    "author_id": 313889,
                    "given_name": "Carly L.A.",
                    "family_name": "Wender",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359839,
                    "given_name": "Odalys",
                    "family_name": "Arbelaez",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359840,
                    "given_name": "Tien T.",
                    "family_name": "Tong",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 147498,
                    "given_name": "Amber",
                    "family_name": "Salter",
                    "ORCID": "http://orcid.org/0000-0002-1088-110X",
                    "country": "US"
                },
                {
                    "author_id": 251160,
                    "given_name": "Glenn R.",
                    "family_name": "Wylie",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 157564,
                    "given_name": "Robert W.",
                    "family_name": "Motl",
                    "ORCID": "http://orcid.org/0000-0003-0112-2803",
                    "country": null
                },
                {
                    "author_id": 252742,
                    "given_name": "Brian M.",
                    "family_name": "Sandroff",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 237141,
                    "given_name": "Nancy D.",
                    "family_name": "Chiaravalloti",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:28:03.406507Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.cct.2024.107630",
            "access": "restricted",
            "takeaways": "",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285852,
            "title": "French consensus procedure for neuropsychological assessment in multiple sclerosis",
            "summary": "Cognitive impairment is one of the invisible symptoms of Multiple sclerosis (MS), which could be associated with depression, unemployment, reduced social interaction, inability to drive, and compromised quality of life. Moreover, the presence of cognitive impairment can be considered as a long-term prognostic factor and in the follow-up of disability. So, cognitive assessment is a crucial element in clinical follow-up of patients with MS (pwMS). International recommendations mention the use of...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39003098/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Elsevier BV",
            "container_title": "Revue Neurologique",
            "authors": [
                {
                    "author_id": 359831,
                    "given_name": "C.",
                    "family_name": "Jougleux",
                    "ORCID": "http://orcid.org/0000-0001-5347-8217",
                    "country": null
                },
                {
                    "author_id": 359832,
                    "given_name": "H.",
                    "family_name": "Joly",
                    "ORCID": "http://orcid.org/0000-0002-5011-9136",
                    "country": null
                },
                {
                    "author_id": 359833,
                    "given_name": "H.",
                    "family_name": "Brissard",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 322223,
                    "given_name": "B.",
                    "family_name": "Lenne",
                    "ORCID": "http://orcid.org/0000-0002-2150-705X",
                    "country": null
                },
                {
                    "author_id": 359834,
                    "given_name": "S.",
                    "family_name": "François",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359835,
                    "given_name": "F.",
                    "family_name": "Hamelin",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 267478,
                    "given_name": "N.",
                    "family_name": "Derache",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359836,
                    "given_name": "J.",
                    "family_name": "Morin",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359837,
                    "given_name": "F.",
                    "family_name": "Reuter",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359838,
                    "given_name": "R.",
                    "family_name": "Colamarino",
                    "ORCID": "http://orcid.org/0009-0005-9083-2998",
                    "country": null
                },
                {
                    "author_id": 267520,
                    "given_name": "A.",
                    "family_name": "Ruet",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:28:01.591833Z",
            "article_subject_relevances": [],
            "doi": "10.1016/j.neurol.2024.06.005",
            "access": "restricted",
            "takeaways": "Cognitive impairment is one of the invisible symptoms of Multiple sclerosis (MS). It could be associated with depression, unemployment, reduced social interaction, inability to drive",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285851,
            "title": "High-intensity interval training improves bone remodeling, lipid profile, and physical function in multiple sclerosis patients",
            "summary": "<jats:title>Abstract</jats:title><jats:p>Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease due to an autoimmune chronic inflammatory response, yet the etiology is currently not completely understood. It is already known that physical activity plays an essential role in improving quality of life, especially in neuropathological conditions. The study was aimed to investigate the possible benefits of high-intensity interval training (HIIT) in bone and lipid metabolism markers, and neuromotor abilities in MS patients. 130 participants were recruited; 16 subjects with MS met the inclusion criteria and were included in the data analysis. The patients were randomly assigned to two groups: a Control group (CG) (34.88 ± 4.45 yrs) that didn’t perform any physical activity and the Exercise group (EG) (36.20 ± 7.80 yrs) that performed HIIT protocol. The training program was conducted remotely by a kinesiologist. It was performed three times a week for 8 weeks. At the beginning (T0) and the end of the study (T1) physical function tests, bone remodelling markers, and lipid markers analyses were performed. After 8 weeks of training the wall squat (s) (T0 = 27.18  ±  4.21; T1 = 41.68 ± 5.38, <jats:italic>p</jats:italic> ≤ 0.01) and Time Up and Go test (s) (T0 = 7.65 ± 0.43; T1 = 6.34 ± 0.38 <jats:italic>p</jats:italic> ≤ 0.01) performances improved; lipid markers analysis showed a decrease in Total (mg/dl) (T0 = 187.22 ± 15.73; T1 = 173.44 ± 13.03, <jats:italic>p</jats:italic> ≤ 0.05) and LDL (mg/dl) (T0 = 108 ± 21.08; T1 = 95.02 ± 17.99, <jats:italic>p</jats:italic> &lt; 0.05) cholesterol levels. Additionally, the levels of osteocalcin (µg/L), a marker of bone formation increased (T0 = 20.88 ± 4.22; T1 = 23.66 ± 6.24, <jats:italic>p</jats:italic> &lt; 0.05), 25-OH Vitamin D (µg/L) improved after 8 weeks (T0 = 21.11 ± 7.11; T1 = 27.66 ± 7.59, <jats:italic>p</jats:italic> &lt; 0.05). HIIT had an effect on lower limb strength and gait control, improved bone formation, and lipid management, in MS patients.</jats:p>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39003295/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Scientific Reports",
            "authors": [
                {
                    "author_id": 334824,
                    "given_name": "Alessandra",
                    "family_name": "Amato",
                    "ORCID": "http://orcid.org/0000-0002-6512-3840",
                    "country": null
                },
                {
                    "author_id": 359824,
                    "given_name": "Patrizia",
                    "family_name": "Proia",
                    "ORCID": "http://orcid.org/0000-0002-0326-5560",
                    "country": null
                },
                {
                    "author_id": 269586,
                    "given_name": "Anna",
                    "family_name": "Alioto",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359825,
                    "given_name": "Carlo",
                    "family_name": "Rossi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359826,
                    "given_name": "Andrea",
                    "family_name": "Pagliaro",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 169918,
                    "given_name": "Paolo",
                    "family_name": "Ragonese",
                    "ORCID": "http://orcid.org/0000-0003-2516-1567",
                    "country": null
                },
                {
                    "author_id": 283448,
                    "given_name": "Giuseppe",
                    "family_name": "Schirò",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 178531,
                    "given_name": "Giuseppe",
                    "family_name": "Salemi",
                    "ORCID": "http://orcid.org/0000-0002-3756-4323",
                    "country": "IT"
                },
                {
                    "author_id": 359827,
                    "given_name": "Rosalia",
                    "family_name": "Caldarella",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359828,
                    "given_name": "Sonya",
                    "family_name": "Vasto",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359829,
                    "given_name": "Robert",
                    "family_name": "Nowak",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 271625,
                    "given_name": "Dorota",
                    "family_name": "Kostrzewa-Nowak",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 164366,
                    "given_name": "Giuseppe",
                    "family_name": "Musumeci",
                    "ORCID": "http://orcid.org/0000-0002-8260-8890",
                    "country": null
                },
                {
                    "author_id": 359830,
                    "given_name": "Sara",
                    "family_name": "Baldassano",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:27:59.670797Z",
            "article_subject_relevances": [],
            "doi": "10.1038/s41598-024-66448-5",
            "access": "open",
            "takeaways": "MS is a demyelinating and neurodegenerative disease due to an autoimmune chronic inflammatory response. The study aimed to investigate the possible benefits of high-intensity interval training (HIIT) in bone and lipid metabolism markers, and neuromotor abilities in MS patients. HIIT had an effect on lower limb strength and gait control, improved bone formation, and lipid management in MS patient.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285850,
            "title": "Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis",
            "summary": "<jats:title>Abstract</jats:title><jats:sec>\n              <jats:title>Background and objectives</jats:title>\n              <jats:p>In multiple sclerosis (MS), <jats:italic>slowly expanding lesions</jats:italic> were shown to be associated with worse disability and prognosis. Their timely detection from cross-sectional data at early disease stages could be clinically relevant to inform treatment planning. Here, we propose to use multiparametric, quantitative MRI to allow a better cross-sectional characterization of lesions with different longitudinal phenotypes.</jats:p>\n            </jats:sec><jats:sec>\n              <jats:title>Methods</jats:title>\n              <jats:p>We analysed T1 and T2 relaxometry maps from a longitudinal cohort of MS patients. Lesions were classified as enlarging, shrinking, new or stable based on their longitudinal volumetric change using a newly developed automated technique. Voxelwise deviations were computed as z-scores by comparing individual patient data to T1, T2 and T2/T1 normative values from healthy subjects. We studied the distribution of microstructural properties inside lesions and within perilesional tissue.</jats:p>\n            </jats:sec><jats:sec>\n              <jats:title>Results and conclusions</jats:title>\n              <jats:p>Stable lesions exhibited the highest T1 and T2 z-scores in lesion tissue, while the lowest values were observed for new lesions. Shrinking lesions presented the highest T1 z-scores in the first perilesional ring while enlarging lesions showed the highest T2 z-scores in the same region. Finally, a classification model was trained to predict the longitudinal lesion type based on microstructural metrics and feature importance was assessed. Z-scores estimated in lesion and perilesional tissue from T1, T2 and T2/T1 quantitative maps carry discriminative and complementary information to classify longitudinal lesion phenotypes, hence suggesting that multiparametric MRI approaches are essential for a better understanding of the pathophysiological mechanisms underlying disease activity in MS lesions.</jats:p>\n            </jats:sec>",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39003428/?fc=20210216052009&ff=20240714072756&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 1,
                    "subject_name": "Multiple Sclerosis",
                    "description": null,
                    "team_id": 1
                }
            ],
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Journal of Neurology",
            "authors": [
                {
                    "author_id": 322815,
                    "given_name": "Veronica",
                    "family_name": "Ravano",
                    "ORCID": "http://orcid.org/0000-0002-1532-9664",
                    "country": null
                },
                {
                    "author_id": 183057,
                    "given_name": "Michaela",
                    "family_name": "Andelova",
                    "ORCID": "http://orcid.org/0000-0002-3812-7483",
                    "country": null
                },
                {
                    "author_id": 322816,
                    "given_name": "Gian Franco",
                    "family_name": "Piredda",
                    "ORCID": "http://orcid.org/0000-0002-8449-6634",
                    "country": null
                },
                {
                    "author_id": 359818,
                    "given_name": "Stefan",
                    "family_name": "Sommer",
                    "ORCID": "http://orcid.org/0000-0003-3484-1679",
                    "country": null
                },
                {
                    "author_id": 359819,
                    "given_name": "Samuele",
                    "family_name": "Caneschi",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359820,
                    "given_name": "Lucia",
                    "family_name": "Roccaro",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 322817,
                    "given_name": "Jan",
                    "family_name": "Krasensky",
                    "ORCID": "http://orcid.org/0000-0002-5605-8821",
                    "country": null
                },
                {
                    "author_id": 359821,
                    "given_name": "Matej",
                    "family_name": "Kudrna",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 151316,
                    "given_name": "Tomas",
                    "family_name": "Uher",
                    "ORCID": "http://orcid.org/0000-0003-3160-9022",
                    "country": null
                },
                {
                    "author_id": 359822,
                    "given_name": "Ricardo A.",
                    "family_name": "Corredor-Jerez",
                    "ORCID": "http://orcid.org/0000-0002-8172-9850",
                    "country": null
                },
                {
                    "author_id": 322821,
                    "given_name": "Jonathan A.",
                    "family_name": "Disselhorst",
                    "ORCID": "http://orcid.org/0000-0002-2924-1866",
                    "country": "CH"
                },
                {
                    "author_id": 322823,
                    "given_name": "Bénédicte",
                    "family_name": "Maréchal",
                    "ORCID": "http://orcid.org/0000-0001-7866-2854",
                    "country": null
                },
                {
                    "author_id": 322822,
                    "given_name": "Tom",
                    "family_name": "Hilbert",
                    "ORCID": "http://orcid.org/0000-0001-8207-4908",
                    "country": null
                },
                {
                    "author_id": 322824,
                    "given_name": "Jean-Philippe",
                    "family_name": "Thiran",
                    "ORCID": "http://orcid.org/0000-0003-2938-9657",
                    "country": "CH"
                },
                {
                    "author_id": 322825,
                    "given_name": "Jonas",
                    "family_name": "Richiardi",
                    "ORCID": "http://orcid.org/0000-0002-6975-5634",
                    "country": null
                },
                {
                    "author_id": 178510,
                    "given_name": "Dana",
                    "family_name": "Horáková",
                    "ORCID": "http://orcid.org/0000-0003-1915-0036",
                    "country": "CZ"
                },
                {
                    "author_id": 359823,
                    "given_name": "Manuela",
                    "family_name": "Vaneckova",
                    "ORCID": "http://orcid.org/0000-0001-6895-3738",
                    "country": null
                },
                {
                    "author_id": 199338,
                    "given_name": "Tobias",
                    "family_name": "Kober",
                    "ORCID": "http://orcid.org/0000-0001-7598-9456",
                    "country": "CH"
                }
            ],
            "discovery_date": "2024-07-14T11:27:57.860534Z",
            "article_subject_relevances": [],
            "doi": "10.1007/s00415-024-12568-x",
            "access": "open",
            "takeaways": "In MS, slowly expanding lesions were shown to be associated with worse disability and prognosis. Lesions were classified as enlarging, shrinking, new or stable based on their longitudinal volumetric change. Stable lesions exhibited the highest T1 and T2 z-scores in lesion tissue, while the lowest values were observed for new lesions.",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285849,
            "title": "Dtx2 deficiency induces ependymo-radial glial cell proliferation and improves spinal cord motor function recovery",
            "summary": "Traumatic injury to the spinal cord can lead to significant, permanent disability. Mammalian spinal cords are not capable of regeneration; in contrast, adult zebrafish are capable of such regeneration, fully recovering motor function. Understanding the mechanisms underlying zebrafish neuroregeneration may provide useful information regarding endogenous regenerative potential and aid in the development of therapeutic strategies in humans. DTXs regulate a variety of cellular processes. However,...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39001828/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
                }
            ],
            "publisher": "Mary Ann Liebert Inc",
            "container_title": "Stem Cells and Development",
            "authors": [
                {
                    "author_id": 359810,
                    "given_name": "Hao-Yuan",
                    "family_name": "Chen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359811,
                    "given_name": "Yin-Cheng",
                    "family_name": "Huang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359812,
                    "given_name": "Tu-Hsueh",
                    "family_name": "Yeh",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359813,
                    "given_name": "Chia-Wei",
                    "family_name": "Chang",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359814,
                    "given_name": "Yang-Jin",
                    "family_name": "Shen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359815,
                    "given_name": "Yi-Chieh",
                    "family_name": "Chen",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359816,
                    "given_name": "Mu-Qun",
                    "family_name": "Sun",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359817,
                    "given_name": "Yi-Chuan",
                    "family_name": "Cheng",
                    "ORCID": null,
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:25:20.076663Z",
            "article_subject_relevances": [],
            "doi": "10.1089/scd.2023.0247",
            "access": "restricted",
            "takeaways": "Traumatic injury to the spinal cord can lead to permanent disability. Mammalian spinal cords are not capable of regeneration. Adult zebrafish",
            "team_categories": [],
            "ml_predictions": []
        },
        {
            "article_id": 285848,
            "title": "Conjugation of Lysozyme and Epigallocatechin Gallate for Improving Antibacterial and Antioxidant Properties",
            "summary": "One of the main interests in the food industry is the preservation of food from spoilage by microorganisms or lipid oxidation. A novel alternative is the development of additives of natural origin with dual activity. In the present study, a chemically modified lysozyme (Lys) with epigallocatechin gallate (EGCG) was developed to obtain a conjugate (Lys-EGCG) with antibacterial/antioxidant activity to improve its properties and increase its application potential. The modification reaction was...",
            "link": "https://pubmed.ncbi.nlm.nih.gov/39001894/?fc=20240608182355&ff=20240714072506&v=2.18.0.post9+e462414",
            "published_date": "2024-07-13T10:00:00Z",
            "sources": [
                "PubMed CNS Regenerate"
            ],
            "teams": [
                {
                    "id": 1,
                    "name": "Team Gregory",
                    "is_active": true,
                    "created": "2024-05-04T18:35:11.961532Z",
                    "modified": "2024-07-04T10:58:33.274216Z",
                    "slug": "team-gregory",
                    "users": [
                        1,
                        3
                    ]
                }
            ],
            "subjects": [
                {
                    "id": 2,
                    "subject_name": "CNS Regeneration",
                    "description": "https://pubmed.ncbi.nlm.nih.gov/rss/search/1dmEOdK-P_-UBN_co2XahWMyPwt10E-2wAci7qgyqB1wWIwkJY/?limit=100&utm_campaign=pubmed-2&fc=20240608182355\r\n\r\n((\"Central Nervous System Regeneration\" OR \"Neuroregeneration\" OR \"Neural Regeneration\" OR \"Central Nervous System Repair\") \r\nOR (\"Myelination\" OR \"Remyelination\" OR \"Myelin Repair\" OR \"Oligodendrocyte Differentiation\" OR \"Oligodendrocyte Progenitor Cells\" OR \"Myelin Regeneration\") \r\nOR (\"Stem Cells and Myelin Production\" OR \"Neural Stem Cells\" OR \"Growth Factors for Myelin Regeneration\" OR \"Neurotrophic Factors\" OR \"Glial Cell Line-Derived Neurotrophic Factor\") \r\nOR (\"Gene Therapy for CNS Repair\" OR \"Gene Therapy for Myelination\" OR \"Molecular Targets for Myelin Regeneration\" OR \"Epigenetic Regulation of Myelination\") \r\nOR (\"Pharmacological Agents for CNS Regeneration\" OR \"Drugs Promoting Myelination\" OR \"Neuroprotective Agents\" OR \"Remyelinating Drugs\" OR \"Small Molecules for Myelin Repair\") \r\nOR (\"Novel Treatments for CNS Repair\" OR \"Emerging Therapies for Myelin Regeneration\"))",
                    "team_id": 1
                }
            ],
            "publisher": "Springer Science and Business Media LLC",
            "container_title": "Current Microbiology",
            "authors": [
                {
                    "author_id": 359802,
                    "given_name": "María J.",
                    "family_name": "Moreno-Vásquez",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359803,
                    "given_name": "Manuel I.",
                    "family_name": "Carretas-Valdez",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359804,
                    "given_name": "Ana G.",
                    "family_name": "Luque-Alcaraz",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359805,
                    "given_name": "Idania E.",
                    "family_name": "Quintero-Reyes",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359806,
                    "given_name": "José A.",
                    "family_name": "Tapia-Hernández",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359807,
                    "given_name": "Aldo A.",
                    "family_name": "Arvizu-Flores",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359808,
                    "given_name": "Elena N.",
                    "family_name": "Moreno-Córdova",
                    "ORCID": null,
                    "country": null
                },
                {
                    "author_id": 359809,
                    "given_name": "Abril Z.",
                    "family_name": "Graciano-Verdugo",
                    "ORCID": "http://orcid.org/0000-0003-1020-3840",
                    "country": null
                }
            ],
            "discovery_date": "2024-07-14T11:25:18.680589Z",
            "article_subject_relevances": [],
            "doi": "10.1007/s00284-024-03776-9",
            "access": "restricted",
            "takeaways": "The main interest in the food industry is the preservation of food from spoilage by microorganisms or lipid oxidation. A novel alternative is the development of additives of",
            "team_categories": [],
            "ml_predictions": []
        }
    ]
}